Glucose production in response to glucagon is comparable in preterm AGA and SGA infants

Kempen, Anne A. M. W. van; Ackermans, Mariëtte T.; Endert, E.; Kok, Johnn Henry Herrera; Sauerwein, Hans P.

doi:10.1016/j.clnu.2005.02.004

Cited by 15 publications

(10 citation statements)

References 46 publications

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“…In premature neonates, glucagon administration stimulated similar rises in glucose concentrations. Subsequent studies have confirmed that glucagon can produce a brisk glycemic response when plasma glucose concentrations are low both in normal and in SGA or premature neonates (35–39). …”

Section: Transitional Neonatal Hypoglycemia In Normal Newborns Is Assmentioning

confidence: 92%

Re-Evaluating “Transitional Neonatal Hypoglycemia”: Mechanism and Implications for Management

Stanley

Rozance

Thornton

et al. 2015

The Journal of Pediatrics

198

159

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Section: Transitional Neonatal Hypoglycemia In Normal Newborns Is Assmentioning

confidence: 92%

Re-Evaluating “Transitional Neonatal Hypoglycemia”: Mechanism and Implications for Management

Stanley

Rozance

Thornton

et al. 2015

The Journal of Pediatrics

198

159

View full text Add to dashboard Cite

show abstract

“…Because a change in the plasma glucose concentration is not necessarily a good parameter for a change in EGP, more insight in glucose kinetics must be obtained by combining the glucagon test with stable isotope studies [103]. This technique was used to measure EGP in response to glucagon in (preterm) infants [104][105][106][107] and in adults [97,[108][109][110], showing a 4.5-and 9-fold increase in EGP, respectively. In children, merely case reports have been published on this subject [111,112].…”

Section: Glycogenolysis and Glycogen Contentmentioning

confidence: 99%

Glucose metabolism in children: influence of age, fasting, and infectious diseases

et al. 2009

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“…Liver glycogen stores are limited in neonates born before 28 weeks of gestation because glycogen storage primarily takes place during the third trimester. One recent study showed that in infants less than 32 weeks’ gestational age and 3–6 days’ postnatal age glucose production increased in response to glucagon [11]. This was mainly due to an increase in glycogenolysis.…”

Section: Altered Glucose Metabolism In Preterm Infantsmentioning

confidence: 99%

Glucose Regulation in Preterm Newborn Infants

Mitanchez¹

2007

Horm Res Paediatr

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After birth, continuous transplacental transfer of glucose is interrupted. Neonates have to provide brain and vital organs with sufficient glucose. In term newborn infants, this is accomplished through well-coordinated hormonal and metabolic adaptive changes. During the first week of life, preterm infants are at high risk of abnormal glucose homeostasis. They are at risk of hypoglycemia due to limited glycogen and fat stores that should have occurred in the third trimester. Continuous glucose infusion is always required soon after birth to maintain the glucose level. However, under such conditions, many preterm infants develop hyperglycemia. Defective islet β-cell processing of proinsulin is likely related to hyperglycemia. There is also evidence that preterm infants are partially resistant to insulin. By contrast with adults, hepatic glucose production is not suppressed during parenteral glucose infusion. Exogenous insulin infusion partially reduces endogenous glucose production in preterm newborn infants. This treatment is efficient and safe when used with caution. More research is needed to understand the specificity of glucose homeostasis in preterm infants and to evaluate the long-term consequences of metabolic and nutritional support during early life.

show abstract

Glucose production in response to glucagon is comparable in preterm AGA and SGA infants

Cited by 15 publications

References 46 publications

Re-Evaluating “Transitional Neonatal Hypoglycemia”: Mechanism and Implications for Management

Re-Evaluating “Transitional Neonatal Hypoglycemia”: Mechanism and Implications for Management

Glucose metabolism in children: influence of age, fasting, and infectious diseases

Glucose Regulation in Preterm Newborn Infants

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