Glucose oxidation by adipose tissue of the edible dormouse (Gus glis) during hibernation and arousal: Effect of insulin

Biochemical adaptations of mammalian hibernation: exploring squirrels as a perspective model for naturally induced reversible insulin resistance

“…Hibernators such as yellow-bellied marmots showed significant increases in plasma insulin levels during periods of weight gain characterized with peripheral insulin resistance and hyperinsulinemia 18. In vitro studies also showed that glucose oxidation of adipose tissue upon insulin stimulation in hibernating dormice was drastically reduced compared to active dormice, suggesting insulin resistance during hibernation 19. Similar results were found in hibernating hedgehogs, where a lack of insulin response was found in adipocytes at low temperature 20.…”

Biochemical adaptations of mammalian hibernation: exploring squirrels as a perspective model for naturally induced reversible insulin resistance

“…Hibernators such as yellow-bellied marmots showed significant increases in plasma insulin levels during periods of weight gain characterized with peripheral insulin resistance and hyperinsulinemia 18. In vitro studies also showed that glucose oxidation of adipose tissue upon insulin stimulation in hibernating dormice was drastically reduced compared to active dormice, suggesting insulin resistance during hibernation 19. Similar results were found in hibernating hedgehogs, where a lack of insulin response was found in adipocytes at low temperature 20.…”

Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid

“…The actions of chronically high insulin levels are usually associated with insulin resistance in type 2 diabetes (T2DM). Lack of insulin response has also been reported in hibernating dormice and hedgehogs ( 20 , 21 ). These observations imply there may be some similar metabolic regulation mechanisms between type 2 diabetic mice and hibernating animals.…”

Biochemical adaptations of mammalian hibernation: exploring squirrels as a perspective model for naturally induced reversible insulin resistance

“…Hibernators such as yellow-bellied marmots showed significant increases in plasma insulin levels during periods of weight gain characterized with peripheral insulin resistance and hyperinsulinemia 18. In vitro studies also showed that glucose oxidation of adipose tissue upon insulin stimulation in hibernating dormice was drastically reduced compared to active dormice, suggesting insulin resistance during hibernation 19. Similar results were found in hibernating hedgehogs, where a lack of insulin response was found in adipocytes at low temperature 20.…”

Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid

“…The actions of chronically high insulin levels are usually associated with insulin resistance in type 2 diabetes (T2DM). Lack of insulin response has also been reported in hibernating dormice and hedgehogs ( 20 , 21 ). These observations imply there may be some similar metabolic regulation mechanisms between type 2 diabetic mice and hibernating animals.…”

Biochemical adaptations of mammalian hibernation: exploring squirrels as a perspective model for naturally induced reversible insulin resistance

“…Hibernators such as yellow-bellied marmots showed significant increases in plasma insulin levels during periods of weight gain characterized with peripheral insulin resistance and hyperinsulinemia 18. In vitro studies also showed that glucose oxidation of adipose tissue upon insulin stimulation in hibernating dormice was drastically reduced compared to active dormice, suggesting insulin resistance during hibernation 19. Similar results were found in hibernating hedgehogs, where a lack of insulin response was found in adipocytes at low temperature 20.…”

Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid

“…The actions of chronically high insulin levels are usually associated with insulin resistance in type 2 diabetes (T2DM). Lack of insulin response has also been reported in hibernating dormice and hedgehogs ( 20 , 21 ). These observations imply there may be some similar metabolic regulation mechanisms between type 2 diabetic mice and hibernating animals.…”