Glucose oxidation by adipose tissue of the edible dormouse (Gus glis) during hibernation and arousal: Effect of insulin

Castex, C.; Tahri, Abir; Hoo-Paris, R.; Sutter, B. C. J.

doi:10.1016/0300-9629(87)90094-6

Cited by 11 publications

(2 citation statements)

References 14 publications

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“…Hibernators such as yellow-bellied marmots showed significant increases in plasma insulin levels during periods of weight gain characterized with peripheral insulin resistance and hyperinsulinemia 18. In vitro studies also showed that glucose oxidation of adipose tissue upon insulin stimulation in hibernating dormice was drastically reduced compared to active dormice, suggesting insulin resistance during hibernation 19. Similar results were found in hibernating hedgehogs, where a lack of insulin response was found in adipocytes at low temperature 20.…”

Section: Metabolic Dysregulation Of T2dm and Hibernation Metabolismsupporting

confidence: 53%

Biochemical adaptations of mammalian hibernation: exploring squirrels as a perspective model for naturally induced reversible insulin resistance

Storey

2013

Braz J Med Biol Res

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An important disease among human metabolic disorders is type 2 diabetes mellitus. This disorder involves multiple physiological defects that result from high blood glucose content and eventually lead to the onset of insulin resistance. The combination of insulin resistance, increased glucose production, and decreased insulin secretion creates a diabetic metabolic environment that leads to a lifetime of management. Appropriate models are critical for the success of research. As such, a unique model providing insight into the mechanisms of reversible insulin resistance is mammalian hibernation. Hibernators, such as ground squirrels and bats, are excellent examples of animals exhibiting reversible insulin resistance, for which a rapid increase in body weight is required prior to entry into dormancy. Hibernator studies have shown differential regulation of specific molecular pathways involved in reversible resistance to insulin. The present review focuses on this growing area of research and the molecular mechanisms that regulate glucose homeostasis, and explores the roles of the Akt signaling pathway during hibernation. Here, we propose a link between hibernation, a well-documented response to periods of environmental stress, and reversible insulin resistance, potentially facilitated by key alterations in the Akt signaling network, PPAR-γ/PGC-1α regulation, and non-coding RNA expression. Coincidentally, many of the same pathways are frequently found to be dysregulated during insulin resistance in human type 2 diabetes. Hence, the molecular networks that may regulate reversible insulin resistance in hibernating mammals represent a novel approach by providing insight into medical treatment of insulin resistance in humans.

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Section: Metabolic Dysregulation Of T2dm and Hibernation Metabolismsupporting

confidence: 53%

Biochemical adaptations of mammalian hibernation: exploring squirrels as a perspective model for naturally induced reversible insulin resistance

Storey

2013

Braz J Med Biol Res

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“…The actions of chronically high insulin levels are usually associated with insulin resistance in type 2 diabetes (T2DM). Lack of insulin response has also been reported in hibernating dormice and hedgehogs ( 20 , 21 ). These observations imply there may be some similar metabolic regulation mechanisms between type 2 diabetic mice and hibernating animals.…”

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confidence: 68%

Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid

Zhao

Cheng

Zhao

et al. 2021

Journal of Biological Chemistry

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Does the Road Traveled Matter? Natural Versus Prematurely Induced Arousal from Torpor

Utz

Breukelen

2012

Living in a Seasonal World

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Glucose oxidation by adipose tissue of the edible dormouse (Gus glis) during hibernation and arousal: Effect of insulin

Cited by 11 publications

References 14 publications

Biochemical adaptations of mammalian hibernation: exploring squirrels as a perspective model for naturally induced reversible insulin resistance

Biochemical adaptations of mammalian hibernation: exploring squirrels as a perspective model for naturally induced reversible insulin resistance

Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid

Does the Road Traveled Matter? Natural Versus Prematurely Induced Arousal from Torpor

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