Glucose metabolites, glutamate and glycerol in malignant glioma tumours during radiotherapy

Tabatabaei, Pedram; Bergström, Per; Henriksson, Roger; Bergenheim, A. Tommy

doi:10.1007/s11060-008-9625-2

Cited by 41 publications

(48 citation statements)

References 14 publications

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“…The (glutamate-glutamine)-to-creatine ratio in patients with GBM agrees with reports of higher levels of glutamate in the tumor than in peritumoral tissue ( 5 ), which is consistent with reports that GBM secretes large amounts of glutamate ( 38,39 ).…”

Section: Discussionsupporting

confidence: 91%

“…Currently, biopsy is required to confi rm the nature of a glioma. One-dimensional (1D) MR spectroscopy of the brain has been shown to enable the delineation of glioma from other types of brain tumors by means of an increased choline-to-creatine ratio, the presence of lactate, and an increase in myo -inositol and lipid concentration with the concomitant reduction or absence of the N -acetylaspartate (NAA) resonance (1)(2)(3)(4)(5)(6)(7).…”

mentioning

confidence: 99%

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Use of in Vivo Two-dimensional MR Spectroscopy to Compare the Biochemistry of the Human Brain to That of Glioblastoma

Ramadan¹,

Andronesi²,

Stanwell³

et al. 2011

Radiology

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Localized correlation spectroscopy of the human brain at 3.0 T with use of a 32-channel head coil was performed in 11 minutes and provided information about neurotransmitters, metabolites, lipids, and macromolecules. The method was able to help differentiate healthy brain from the biochemical signature of GBM in vivo. This method may, in the future, reduce the need for biopsy and is now applicable for the study of selected neurologic diseases.

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Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 99%

Use of in Vivo Two-dimensional MR Spectroscopy to Compare the Biochemistry of the Human Brain to That of Glioblastoma

Ramadan¹,

Andronesi²,

Stanwell³

et al. 2011

Radiology

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“…Tabatabaei et al [24]. used microdialysis to study the effects of radiotherapy on metabolism in 13 patients with malignant glioma to determine the levels of glucose, lactate, pyruvate, glutamate, and glycerol in tumor tissue during baseline conditions and to detect any changes in these metabolic markers during radiotherapy.…”

Section: Application Of Microdialysis In Neuro-oncologymentioning

confidence: 99%

Clinical microdialysis in neuro-oncology: principles and applications

Goodman¹

2011

Chin J Cancer

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Clinical microdialysis allows a discrete volume of the brain to be sampled for neurochemical analysis of neurotransmitters, metabolites, biomarkers, and drugs. The technique can be safely used in humans intraoperatively, in the intensive care unit, and in ambulatory settings. Microdialysis probes, micropumps, and analytical equipment are commercially available and have been used extensively for neurochemical monitoring in traumatic brain injury, stroke, and subarachnoid hemorrhage. There has been very limited use of microdialysis in neuro-oncology, but this technique has great promise in the study of the basic neurochemistry of brain tumors, alterations in neurochemistry in response to therapy, and the pharmacokinetics of chemotherapeutic agents. Microdialysis probes may also be used to deliver drugs while simultaneously permitting monitoring of neurochemical changes induced by this therapy.

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“…In their second study the Swedish group evaluated the levels of glucose and its metabolites, glycerol and glutamate in patients with HGG undergoing conventional post-operative radiotherapy (Tabatabaei et al 2008). Thirteen patients with HGG were recruited with one catheter placed within the tumour (T), and a second 10mm outside the contrast-enhancing area in the peritumour region (PT).…”

Section: Radiotherapymentioning

confidence: 99%