Glucose metabolism in the idiopathic blepharoptosis: Utility of the Oral Glucose Tolerance Test (OGTT) and of the Insulin Resistance Index

Dementia is associated with Insulin Resistance in patients with Parkinson's Disease

“…The same authors showed that an appreciable number of subjects (9,6%; aged: 40-79 years) was IR but free of metabolic disorders. Moreover, in our previous work, 12% of the general population (aged: 50,5 ± 6,8 years) consisted of normal-weight subjects showed isolated IR [21]. These values are similar to the prevalence rate of IR that we found in the control group of the present study (nondemented PD, DM or IGT free).…”

“…The glucose metabolism, low concentrations of exogenous insulin may increase cerebral glucose metabolism and then modulate selective brain functions such as memory [37]; 2. neuro-transmitter modulation, notably, low doses of insulin can reverse the anamnestic effects of cholinergic blockade [38]; moreover, in humans, rising plasma insulin levels increase CSF norepinephrine [39]. Besides, from our study emerges that the prevalence of DM in PD patients without dementia was similar to that of general population [21]; on the other side, the prevalence of "prediabetes" was strongly associated with dementia in our PD-D patients. Sixty-two percent of PD-D patients had IR of whom, following a 2 h-OGTT, the 30% had also IGT and 26% IR only.…”

“…Few studies assessed the prevalence of isolated IR in the italian general population [20,21]. IR is thought to be a common finding in several metabolic disorders (i.e.…”

“…glucose intolerance, dyslipidemia, DM, hyperuricemia, etc.) [20][21][22][23][24]. Bonora et al found that IR is common in subjects with metabolic disorders, although its prevalence varies among clinical condition.…”

Bell’s palsy: a manifestation of prediabetes?

“…These percentages were significantly higher than those reported in the control group (P < 0.001). In a previous case-control study performed on 162 patients, we found that blepharoptosis is frequently associated with prediabetes (IGT and IR) (15). A decade of small epidemiology studies (13,14) offers evidence that early hyperglycaemia is sufficient to damage distal peripheral nerves.…”