Glucose metabolism in insulin administered euthyroid, hypothyroid and hyperthyroid rats.

Abstract

Glucose metabolism was studied as evidenced by the sugar and pyruvic acid levels in blood and glycogen and pyruvic acid content of tissues in euthyroid, hypothyroid and hyperthyroid rats by giving insulin.

Effect of T3on Insulin Action, Insulin Binding, and Insulin Receptor Kinase Activity in Primary Cultures of Rat Hepatocytes

“…Our studies demonstrate that T 3 induces insulin resistance in the liver with regard to lipid synthesis but not to aminoacid transport. These findings coupled with the previous demonstrations of increased glucose production (Mutter, Paschen and Seitz 1983;Sandler, Robinson, Rabin, Lacy and Abumrad 1983) and decreased glycogen stores (Chandra and Mukkerjee 1985) in the liver from humans and animals with spontaneous or experimentally induced hyperthyroidism suggest that the changes induced by T 3 might be an homeostatic mechanism to prevent hypoglycemia. Hyperthyroidism is associated with increased energy demands (Hoch 1962), therefore, the liver must provide an increased supply of glucose.…”