Glucose metabolism in five neuromuscular disorders

Collis, W. J.; Engel, W. King

doi:10.1212/wnl.18.9.915

Cited by 46 publications

(25 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was clearly shown that glucose metabolism was impaired in patients with not only MND but also SCD, that is, intolerance to oral glucose loading is not specific to MND, as Collis and Engel (1968) previously pointed out. This was also the case with patients with either ALS or OPCA.…”

Section: Discussionsupporting

confidence: 52%

“…The possibility of the former mechanism has not been validated in Koerner's study (1976). However, a decrease in functioning muscle mass accompanying physical inactivity seems most likely the major common mechanism for abnormal glucose metabolism (Collis and Engel 1968;Gustafson and Stortebecker 1972 fibers (type 2A and 2B) and one slowly contracting fiber (type 1) (Dubowitz and Brooke 1973). Type 1 fibers are resistant to fatigue with a high level of oxidative enzyme activity and a low level of phosphorylase activity.…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, it is evident that functional properties of skeletal muscle fibers, either differentiating or differentiated, are considerably dependent on the dominant influence of the innervation. For instance, there are possibilities that synthesis and secretion of LPL, regulation of "glucose receptor space" (Collis and Engel 1968) or metabolic pathways in muscle fibers may be under the dominant influence of nervous input. The intact nerve supply seems essential for the skeletal muscle fibers to fully differentiate into either type fiber, to maintain each distinct metabolic pathway, or to adapt adequately the environmental conditions to change their structure and functional properties.…”

Section: Discussionmentioning

confidence: 99%

“…also are frequently associated with a wide variety of neurologic and neuromuscular disorders most of which involve muscle wasting : Parkinson's disease (Boyd et al 1.971;Van Woert and Mueller 1971;Lipman et al 1974; National Diabetes Data Group 1979), Huntington's chorea (Podolsky et al 1972), muscular dystrophy (Dreyfus et al 1954;Danowski et al 1956;Ionaescu and Luca 1963), myotonic dystrophy (Nadler et al 1950;Jacobson et al 1955;Marshall 1959;Caughey and Saucier 1962;Lee and Hughes 1964), chronic peripheral neuropathy (Collis and Engel 1968), late onset proximal myopathy (Collis and Engel 1968), cerebrovascular disease (Jakobson X967;Gertler et al 1972), Friedreich's ataxia (Podolsky et al 1964;Hewer and Robinson 1968;Podolsky and Sheremata 1970;Podolsky 1975), and ataxia telangiectasia (Barlow et al 1965). However, very little is known about glucose metabolism in other forms of spinocerebellar degeneration (SCD).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Abnormalities of lipoprotein and carbohydrate metabolism in degenerative diseases of the nervous system - Motor neuron disease and spinocerebellar degeneration.

Murai

Miyahara

Tanaka

et al. 1983

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

MURAI, A., MIYAHARA, T., TANAKA, T., KANEKO, T., SAKO, Y. and KAMEYAMA, M. Abnormalities of Lipoprotein and Carbohydrate Metabolism in Degenerative Diseases of the Nervous System -Motor Neuron Disease and Spinocerebellar Degeneration. Tohoku J. exp. Med., 1983, 139 (4), 365-376 The levels of plasma high density lipoprotein (HDL) cholesterol and plasma triglyceride were determined in 44 patients with motor neuron disease (MND) and in 36 patients with spinocerebellar degeneration (SCD). In both groups the HDL cholesterol levels were significantly lower than those in healthy controls, whereas the plasma triglyceride levels were higher than those in the controls. Glucose levels during the oral glucose tolerance test (GTT) were significantly higher in both MND and SCD groups than in healthy controls. Immunoreactive insulin (IRI) levels during GTT were rather higher at 0 and 120 min in both MND and SCD groups than in healthy controls. Glycosylated hemoglobin levels were lower in MND than in the controls. These results indicate that both lipoprotein and carbohydrate metabolisms were impaired in MND and SCD groups. The possibility was presented that denervation might play a part in the pathogenesis of abnormalities of lipoprotein and carbohydrate metabolisms.---motor neuron disease; spinocerebellar degeneration; high density lipoprotein; glucose tolerance test; glycosylated hemoglobin A number of studies have shown a high incidence of impaired glucose metabolism in patients with amyotrophic lateral sclerosis (ALS) (Ionaescu and Luca

show abstract

Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Abnormalities of lipoprotein and carbohydrate metabolism in degenerative diseases of the nervous system - Motor neuron disease and spinocerebellar degeneration.

Murai

Miyahara

Tanaka

et al. 1983

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…While the data examining the relationship between ALS and impaired glucose handling is limited and inconclusive, the finding of hyperglycaemia in ALS patients with severe muscle wasting (Collis and Engel, 1968, Gotoh et al, 1972, Shimizu et al, 2011 raises the possibility that reduced muscle mass may lead to a global disruption in glucose…”

Section: Impaired Glucose Handlingmentioning

confidence: 99%