Glucose Metabolic Rate Kinetic Model Parameter Determination in Humans: The Lumped Constants and Rate Constants for [¹⁸F]Fluorodeoxyglucose and [¹¹C]Deoxyglucose

Abstract

The rate constants and lumped constants (LCs) for [18F]fluorodeoxyglucose ([18F]FDG) and [11C]deoxyglucose ([11C]DG) were determined in humans for the glucose metabolic rate kinetic model used to measure local cerebral glucose consumption. The mean values (+/- SE) of the LCs for [18F]FDG and [11C]DG are 0.52 +/- 0.028 (n = 9) and 0.56 +/- 0.043 (n = 6), respectively. The mean values (+/- SE) of the rate constants k*1, k*2, k*3, and k*4 for [18F]FDG for gray matter are 0.095 +/- 0.005, 0.125 +/- 0.002, 0.069 +/- 0.002, and 0.0055 +/- 0.0003, respectively. The corresponding values for white matter are 0.065 +/- 0.005, 0.126 +/- 0.003, 0.066 +/- 0.002, and 0.0054 +/- 0.0006, respectively. Using these values and previously published values for the rate constants for [11C]DG, the average whole-brain metabolic rates for glucose in normal subjects measured with [18F]FDG and [11C]DG are 5.66 +/- 0.37 (n = 6) and 4.99 +/- 0.23 (n = 6) mg/100 g/min, respectively. These values are not significantly different (t = 1.56, p greater than 0.10) and agree well with reported values in the literature determined by means of the Kety-Schmidt technique.

PET Imaging of Ischemia-Induced Impairment of Mitochondrial Complex I Function in Monkey Brain

“…5% glucose utilization in oxidative phosphorylation. [30][31][32][33][34] For rCMRglc analyses in this study, we applied a fixed lumped constant of 0.56, 23 which is a correction factor to convert FDG metabolic rate into rCMRglc determined from normal human brains. Since a previous study suggested that rCMRglc calculated with a fixed lumped constant would be underestimated at high metabolic rates and overestimated at low metabolic rates, 35 the rCMRglc in inflammatory (ROI PBR ) and infarct (ROI Infarct ) regions might be underestimated and overestimated.…”

Acute Alcohol Effects on Neuronal and Attentional Processing: Striatal Reward System and Inhibitory Sensory Interactions under Acute Ethanol Challenge

“…For quantification of grey matter glucose metabolism, a set of rate constants K1-k4 and a lumped constant were used (Phelps et al, 1979;Reivich et al, 1985). Cortical Regions-of-Interest were manually drawn to calculate the mean cortical rMRGlu for each condition (influx, elimination, placebo).…”

Use of PET Methods for Measurement of Cerebral Energy Metabolism and Hemodynamics in Cerebrovascular Disease

“…Two glucose analogs have been labeled with positron emitters and have been successfully used: carbon-II-labeled 2-deoxy-o-glucose (2DG) and 2-esF]fluoro-2-o-deoxyglucose (FDG) (Phelps et aI., 1979b;Reivich et aI., 1979Reivich et aI., , 1982. In normal subjects, these methods have been partially vali dated since they provide CMRglc values that are in agreement with whole brain CMRglc values pro vided by the Kety-Schmidt method, and the "lumped constant" has now been independently measured by Reivich et al (1985) both for 2DG and FDG (although the inherent assumption that k4 = 0 was made). This method has been subjected to an extensive analysis of model-related errors and lim itations and numerous refinements have been pub lished since its first description (Huang et aI., 1980(Huang et aI., , 1981Brooks, 1982;Wienhard et aI., 1985;Hutchins et aI.…”