Glucose levels as a prognostic marker in patients with ST-segment elevation myocardial infarction: a case–control study

Каретникова, В. Н.; Груздева, О. В.; Uchasova, Evgenya; Осокина, А. В.; Barbarash, O. L.

doi:10.1186/s12902-016-0108-8

Cited by 18 publications

(14 citation statements)

References 14 publications

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“…In our study, out of 79 patients, recurrent MI was seen in 4 patients during the follow up period. This was lower in comparison to the studies of Karetnikova et al 1 In their study, 8 patients with diabetes mellitus and 10 patients without diabetes mellitus had shown recurrent MI during their one year follow up period.…”

Section: Discussioncontrasting

confidence: 69%

“…Our findings are consistent with the findings of Capes et al 8 They found that patients without diabetes who had glucose concentrations more than or equal to range 6.1-8.0 mmol/L had a 3.9-fold (95% CI 2.9-5.4) higher risk of death than patients without diabetes who had lower glucose concentrations. Similarly, in the present study, the mortality rate in diabetic patients was higher (40%) compared to non-diabetics (19%) which is comparatively higher than the findings of Karetnikova et al 1 In his study, the mortality rate was 14.82% in diabetic patients and 10% in non-diabetics (p>0.05).…”

Section: Discussioncontrasting

confidence: 49%

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Random blood glucose on admission as prognostic factor for assessment of severity of acute myocardial infarction

Jain

2019

Int J Res Med Sci

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Background: Assessment of risk factors or prognostic markers is essential to determine the adverse outcome related to acute myocardial infarction (AMI). The aim of the present study was to examine the role of random blood glucose as prognostic marker for assessment of severity of AMI. Methods: This prospective study was conducted on 79 patients with onset symptoms of AMI. All the patients both diabetics and non-diabetics underwent serum blood glucose estimation in the hospital. Primary endpoint of the study was all cause mortality till day 90 follow-up. The secondary end points were composite of death, reinfarction and heart failure till day 90.Mortality rate is higher in the diabetics as compared to nondiabetics. Results: The mean age group was 55.9 years. Males (86%) outnumbered females (14%). The mean BMI was 22.3±2.83. The mean random blood glucose in the study population was 138±92.9 mg/dl (7.7±5.15 mol). Of total 79 patients, 5 were diabetics, of them 2 (40%) died. Among 79 patients, 16 patients were died during 3 months following the qualifying event, 7 had heart failure and 4 had reinfarction. Conclusions: In patients with AMI, hyperglycemia should consider as one of the important prognostic marker to determine the adverse cardiovascular events.

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Section: Discussioncontrasting

confidence: 69%

Section: Discussioncontrasting

confidence: 49%

Random blood glucose on admission as prognostic factor for assessment of severity of acute myocardial infarction

Jain

2019

Int J Res Med Sci

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“…Moreover, a single site study in Russian by Karetnikova et al . [18] showed that hypoglycemia in diabetic patients with AMI was related with poor long-term outcomes.…”

Section: Discussionmentioning

confidence: 99%

Admission Glucose and In-hospital Mortality after Acute Myocardial Infarction in Patients with or without Diabetes

Zhao

Murugiah

et al. 2017

Chinese Medical Journal

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Background:Hyperglycemia on admission has been found to elevate risk for mortality and adverse clinical events after acute myocardial infarction (AMI), but there are evidences that the relationship of blood glucose and mortality may differ between diabetic and nondiabetic patients. Prior studies in China have provided mixed results and are limited by statistical power. Here, we used data from a large, nationally representative sample of patients hospitalized with AMI in China in 2001, 2006, and 2011 to assess if admission glucose is of prognostic value in China and if this relationship differs depending on the presence or absence of diabetes.Methods:Using a nationally representative sample of patients with AMI in China in 2001, 2006, and 2011, we categorized patients according to their glucose levels at admission (< 3.9, 3.9–7.7, 7.8–11.0, and ≥11.1 mmol/L) and compared in-hospital mortality across these admission glucose categories, stratified by diabetes status. Among diabetic and nondiabetic patients, separately, we employed logistic regression to assess the differences in outcomes across admission glucose levels while adjusting for the same covariates.Results:Compared to patients with euglycemia (5.8%), patients with moderate hyperglycemia (13.1%, odds ratio [OR] = 2.44, 95% confidence interval [CI, 2.08–2.86]), severe hyperglycemia (21.5%, OR = 4.42, 95% CI [3.78–5.18]), and hypoglycemia (13.8%, OR = 2.59, 95% CI [1.68–4.00]), all had higher crude in-hospital mortality after AMI regardless of the presence of recognized diabetes mellitus. After adjustment for patients’ characteristics and clinical status, however, the relationship between admission glucose and in-hospital mortality was different for diabetic and nondiabetic patients (P for interaction = 0.045). Among diabetic patients, hypoglycemia (OR = 3.02, 95% CI [1.20–7.63]), moderate hyperglycemia (OR = 1.75, 95% CI [1.04–2.92]), and severe hyperglycemia (OR = 2.97, 95% CI [1.87–4.71]) remained associated with elevated risk for mortality, but among nondiabetic patients, only patients with moderate hyperglycemia (OR = 2.34, 95% CI [1.93–2.84]) and severe hyperglycemia (OR = 3.92, 95% CI [3.04–5.04]) were at elevated mortality risk and not hypoglycemia (OR = 1.12, 95% CI [0.60–2.08]). This relationship was consistent across different study years (P for interaction = 0.900).Conclusions:The relationship between admission glucose and in-hospital mortality differs for diabetic and nondiabetic patients. Hypoglycemia was a bad prognostic marker among diabetic patients alone. The study results could be used to guide risk assessment among AMI patients using admission glucose.Trial Registration:www.clinicaltrials.gov, NCT01624883; https://clinicaltrials.gov/ct2/show/NCT01624883

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“…In addition, these investigators noted that hypoglycemia was associated with an increased mortality rate and that an increase in the average glucose level during the ICU stay was associated with increased mortality. Karetnikova et al studied 529 patients admitted with an ST-segment elevation myocardial infarction [16]. They found a linear association between the blood glucose level and inhospital mortality in nondiabetic patients.…”

Section: Studies In Specific Patient Groupsmentioning

confidence: 99%

The association between admission glucose levels and outcomes in adults admitted to a tertiary care hospital

McGrade

Yang

Nugent

2019

Journal of Community Hospital Internal Medicine Perspectives

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Background: Hyperglycemia at the time of hospital admission has been associated with poor outcomes in several patient groups, but there is little information about this association in hospitalized patients with diverse diagnoses. Methods: We identified all adult patients admitted between 10/1/2015 and 9/30/2016 who had glucose levels measured during the first 24 h after admission to the hospital. Clinical information included age, gender, glucose levels, diagnoses based on ICD 10 discharge coding, length of stay (LOS), and mortality. Patients were classified into quartiles based on glucose levels and into clinically relevant glucose categories. Results: This study included 18,478 adult patients admitted to a tertiary care hospital. The median age was 53 years, the median LOS was 4 days, and the overall in-hospital mortality was 3.8%. The median admission glucose level was 117 mg/dL. Mortality increased in each glucose quartile; it was also highest in patients admitted with a glucose <55 mg/dL or with a glucose >200 mg/dL. The LOS was significantly shorter in patients in glucose quartiles 1 and 2. Conclusions: Admission glucose levels were associated with in-hospital mortality and LOS in this cohort of hospitalized patients. Attention to glucose levels can help identify patients at risk for poor outcomes.

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Glucose levels as a prognostic marker in patients with ST-segment elevation myocardial infarction: a case–control study

Cited by 18 publications

References 14 publications

Random blood glucose on admission as prognostic factor for assessment of severity of acute myocardial infarction

Random blood glucose on admission as prognostic factor for assessment of severity of acute myocardial infarction

Admission Glucose and In-hospital Mortality after Acute Myocardial Infarction in Patients with or without Diabetes

The association between admission glucose levels and outcomes in adults admitted to a tertiary care hospital

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