Glucose intolerance and insulin resistance with aging — studies on insulin receptors and post-receptor events

Fulop, T; Nagy, J; Wórum, I; Fóris, Gabriella; Mudri, K.; Varga, Pál S.; Udvardy, M.

doi:10.1016/0167-4943(87)90003-3

Cited by 18 publications

(4 citation statements)

References 19 publications

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“…In the mid of 1980’s, it was observed that insulin resistance (IR) was associated with the aging process in human tissues [ 167 , 168 ]. Currently, it is known that there exist diverse, tissue-specific mechanisms to repress the signaling through the insulin/IGF-1 pathway.…”

Section: Immunosuppression Immunosenescence and Insulin Resistance Associated With Inflammagingmentioning

confidence: 99%

Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases

Salminen

Kauppinen

2021

Inflamm. Res.

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Background The insulin/IGF-1 signaling pathway has a major role in the regulation of longevity both in Caenorhabditis elegans and mammalian species, i.e., reduced activity of this pathway extends lifespan, whereas increased activity accelerates the aging process. The insulin/IGF-1 pathway controls protein and energy metabolism as well as the proliferation and differentiation of insulin/IGF-1-responsive cells. Insulin/IGF-1 signaling also regulates the functions of the innate and adaptive immune systems. The purpose of this review was to elucidate whether insulin/IGF-1 signaling is linked to immunosuppressive STAT3 signaling which is known to promote the aging process. Methods Original and review articles encompassing the connections between insulin/IGF-1 and STAT3 signaling were examined from major databases including Pubmed, Scopus, and Google Scholar. Results The activation of insulin/IGF-1 receptors stimulates STAT3 signaling through the JAK and AKT-driven signaling pathways. STAT3 signaling is a major activator of immunosuppressive cells which are able to counteract the chronic low-grade inflammation associated with the aging process. However, the activation of STAT3 signaling stimulates a negative feedback response through the induction of SOCS factors which not only inhibit the activity of insulin/IGF-1 receptors but also that of many cytokine receptors. The inhibition of insulin/IGF-1 signaling evokes insulin resistance, a condition known to be increased with aging. STAT3 signaling also triggers the senescence of both non-immune and immune cells, especially through the activation of p53 signaling. Conclusions Given that cellular senescence, inflammaging, and counteracting immune suppression increase with aging, this might explain why excessive insulin/IGF-1 signaling promotes the aging process.

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Section: Immunosuppression Immunosenescence and Insulin Resistance Associated With Inflammagingmentioning

confidence: 99%

Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases

Salminen

Kauppinen

2021

Inflamm. Res.

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“…Moreover, many of the long-lived mouse mutants with disrupted GH/IGF-1 signaling display enhanced insulin sensitivity. In humans, a hallmark phenotype of healthy longevity is maintenance of insulin sensitivity ( 5 , 6 ), which has been observed in familial human longevity ( 7 , 8 ), as well as in centenarians ( 9 – 11 ). Insulin influences all aspects of human physiology ( 12 , 13 ).…”

Section: Introductionmentioning

confidence: 99%

Insulin, Aging, and the Brain: Mechanisms and Implications

2015

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There is now an impressive body of literature implicating insulin and insulin signaling in successful aging and longevity. New information from in vivo and in vitro studies concerning insulin and insulin receptors has extended our understanding of the physiological role of insulin in the brain. However, the relevance of these to aging and longevity remains to be elucidated. Here, we review advances in our understanding of the physiological role of insulin in the brain, how insulin gets into the brain, and its relevance to aging and longevity. Furthermore, we examine possible future therapeutic applications and implications of insulin in the context of available models of delayed and accelerated aging.

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“…A deficiência de alguns minerais traços, tal como zinco, selênio, ferro, cobre e cromo foi relacionada com a promoção de aterosclerose e cromo, zinco e selênio com o aumento da incidência de diabetes (WADA, 2004 (CARR et al, 1998b;LO et al, 1998). Nos músculos e no tecido adiposo, a insulina estimula a remoção da glicose da circulação regulando o tráfico celular do transportador de glicose GLUT4 (FÜLÖP et al, 1987 (AGHDASSI et al, 2006;CARR et al, 1999;ROBERTS et al, 1999). No estudo de Aghdassi et al (2006) Em estudos anteriores, a duração da suplementação avaliada (variou de 1 dia a 8 meses) e a dose utilizada (variou de 100 a 3.000 µg por dia) variaram muito (CEFALU; HU, 2004).…”

Section: Cromounclassified

Efeito da suplementação de cromo na resistência insulínica, na dislipidemia, na inflamação e no estresse oxidativo de pessoas HIV-positivo com lipodistrofia

Pansani¹

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Introdução: Os antirretrovirais (ARV) levam ao desenvolvimento de alterações metabólica, composta por dislipidemias, intolerância à glicose, resistência insulínica, hipertensão e lipodistrofia, associadas ao aumento do risco de doenças cardiovasculares. O cromo é um mineral essencial envolvido no metabolismo dos carboidratos e lipídeos. Ele está relacionado com a melhora da sensibilidade insulínica, das anormalidades metabólicas e da composição corporal. Objetivo: Avaliar o efeito da suplementação com cromo em pessoas HIV-positivo com lipodistrofia em TARV em marcadores do metabolismo da glicose, do metabolismo dos lipídeos, de inflamação e de estresse oxidativo. Materiais e Métodos: Neste estudo de intervenção, duplo-cego, placebo foi avaliado 41 voluntários HIV-positivo com lipodistrofia em TARV. Os voluntários foram randomizados em 2 grupos, 19 no grupo placebo e 22 no grupo cromo. O grupo cromo recebeu 200µg/dia de cromo (Cr 3+) quelato 10% por 3 meses. Antes e após intervenção, todos os voluntários foram submetidos às avaliações clínica, nutricional e bioquímica. As variáveis analisadas foram: resistência insulínica, perfil lipídico, composição corporal, marcadores de inflamação e de estresse oxidativo. Resultados: Os participantes tinham idade (média ± DP) de 47,09 ± 8,15 anos. A composição corporal e os marcadores de inflamação e estresse oxidativo não sofreram alterações após intervenção. Glicemia, insulina, triglicerídeos e o colesterol total e frações, também, não sofreram alterações significativas após 3 meses de suplementação com cromo. No entanto, os participantes que apresentam LDL colesterol alterado (≥ 130mg/dL), a suplementação com cromo foi capaz de reduzir 31,2 mg/dL (p = 0,049, de 176,6 (43,2) mg/dL para 145,4 (32,10) mg/dL). Apesar de não significativo (p = 0,27, de 244,1 (47,1) mg/dL para 220,8 (32,5) mg/dL), a média do colesterol total reduziu 23,8 mg/dL no grupo cromo com colesterol alterado (CT > 200mg/dL). Conclusão: A suplementação de cromo por 3 meses reduziu os níveis de LDL colesterol nos voluntários com hiperlipidemia. Esses resultados sugerem que o tratamento com cromo pode beneficiar indivíduos HIV-positivo com lipodistrofia, sobretudo, aqueles com LDL colesterol aumentado.

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Glucose intolerance and insulin resistance with aging — studies on insulin receptors and post-receptor events

Cited by 18 publications

References 19 publications

Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases

Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases

Insulin, Aging, and the Brain: Mechanisms and Implications

Efeito da suplementação de cromo na resistência insulínica, na dislipidemia, na inflamação e no estresse oxidativo de pessoas HIV-positivo com lipodistrofia

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