Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in East London Asians

Boucher, Barbara J; Mannan, Nasima; Noonan, Kate; Hales, C. N.; Evans, Stephen

doi:10.1007/bf00422375

Cited by 331 publications

(233 citation statements)

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“…Studies showing an inverse association of serum concentration of 25(OH)D with insulin resistance (IR) and b-cell dysfunction provided a further possible explanation for the inverse association between serum concentrations of vitamin D and the prevalence of the MetS (10)(11)(12)(13). Impaired glucose-mediated insulin production and/or IR are key components of the MetS.…”

Section: Introductionmentioning

confidence: 99%

Low 25(OH)D3 levels are associated with total adiposity, metabolic syndrome, and hypertension in Caucasian children and adolescents

Pacifico

Anania

Osborn

et al. 2011

European Journal of Endocrinology

161

122

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Objectives: Evidence of the association between vitamin D and cardiovascular risk factors in the young is limited. We therefore assessed the relationships between circulating 25-hydroxyvitamin D 3 (25(OH)D 3 ) and metabolic syndrome (MetS), its components, and early atherosclerotic changes in 452 (304 overweight/obese and 148 healthy, normal weight) Caucasian children. Methods: We determined serum 25(OH)D 3 concentrations in relation to MetS, its components (central obesity, hypertension, low high-density lipoprotein (HDL)-cholesterol, hypertriglyceridemia, glucose impairment, and/or insulin resistance (IR)), and impairment of flow-mediated vasodilatation (FMD) and increased carotid intima-media thickness (cIMT) -two markers of subclinical atherosclerosis. Results: Higher 25(OH)D 3 was significantly associated with a reduced presence of MetS. Obesity, central obesity, hypertension, hypertriglyceridemia, low HDL-cholesterol, IR, and MetS were all associated with increased odds of having low 25(OH)D 3 levels, after adjustment for age, sex, and Tanner stage. After additional adjustment for SDS-body mass index, elevated blood pressure (BP) and MetS remained significantly associated with low vitamin D status. The adjusted odds ratio (95% confidence interval) for those in the lowest (!17 ng/ml) compared with the highest tertile (O27 ng/ml) of 25(OH)D 3 for hypertension was 1.72 (1.02-2.92), and for MetS, it was 2.30 (1.20-4.40). A similar pattern of association between 25(OH)D 3 , high BP, and MetS was observed when models were adjusted for waist circumference. No correlation was found between 25(OH)D 3 concentrations and either FMD or cIMT. Conclusions: Low 25(OH)D 3 levels in Caucasian children are inversely related to total adiposity, MetS, and hypertension.

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Section: Introductionmentioning

confidence: 99%

Low 25(OH)D3 levels are associated with total adiposity, metabolic syndrome, and hypertension in Caucasian children and adolescents

Pacifico

Anania

Osborn

et al. 2011

European Journal of Endocrinology

161

122

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“…Vitamin D repletion improves insulin sensitivity and insulin secretion in animal studies (25). Hypovitaminosis D has been proposed as a risk factor for reduced insulin secretion, impaired glucose tolerance, and type 2 diabetes in adults (23)(24)(25)(26)(27)(28)(29). However, some studies in obese adults demonstrated no relationship between vitamin D, PTH, and insulin sensitivity (30)(31)(32).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D status and parathyroid hormone in obese children before and after weight loss

Reinehr¹,

Sousa²,

Alexy³

et al. 2007

eur j endocrinol

181

114

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Objective: The roles of vitamin D and parathyroid hormone (PTH) are discussed controversially in obesity, and studies of these hormones in obese children are limited. Therefore, we studied the relationships between PTH, 1,25-dihydroxy-vitamin D (1,25-OH Vit D), 25-hydroxy-vitamin D (25-OH Vit D), weight status, and insulin sensitivity before and after weight loss in obese children. Methods: Fasting serum PTH, 1,25-OH Vit D, 25-OH Vit D, inorganic phosphate, calcium, alkaline phosphatase (AP), insulin, glucose, and weight status (SDS-BMI and percentage body fat) were determined in 133 obese children (median age 12.1 years) and compared with 23 non-obese children. Furthermore, these parameters were analyzed in 67 obese children before and after participating in a 1-year obesity intervention program. Results: Obese children had significantly (P!0.001) higher PTH and lower 25-OH Vit D concentrations compared with non-obese children, while calcium, phosphate, AP, and 1,25-OH Vit D did not differ significantly. Changes of PTH (rZ0.23, PZ0.031) and 25-OH Vit D (rZK0.27, PZ0.013) correlated significantly with changes of SDS-BMI, but not with changes of insulin sensitivity (homeostasis model assessment; HOMA-B%). Reduction of overweight in 35 children led to a significant (P!0.01) decrease of PTH concentrations and an increase in 25-OH Vit D levels. Conclusions: PTH levels were positively and 25-OH Vit D concentrations were negatively related to weight status. Since these alterations normalized after weight loss, these changes are consequences rather than causes of overweight. A relationship between PTH, vitamin D, and insulin sensitivity based on the HOMA index was not found in obese children. Further longitudinal clamp studies are neccessary to study the relationship between vitamin D and insulin sensitivity. European Journal of Endocrinology 157 225-232Introduction Vitamin D and parathyroid hormone (PTH) are well known for their essential role in bone metabolism and calcium homeostasis. The main sources of vitamin D are ergocalciferol and cholecalciferol, the former normally available in food and the latter produced in the skin by u.v. radiation of 7-dehydrocholesterol. Both of these compounds are hydroxylated in the liver to 25-hydroxyvitamin D (25-OH Vit D), which is the major circulating metabolite precursor to the hormonally active form, 1,25-dihydroxy-vitamin D (1,25-OH Vit D).It has become increasingly clear that the vitamin D endocrine system is related to obesity in adults. Obesity has been found to be associated with lower levels of serum 25-OH Vit D (1-5) and higher levels of serum PTH (1,(5)(6)(7)(8). A low vitamin D intake was associated with increased body mass index (BMI) (9). PTH has been postulated as an independent predictor of obesity (7). Overweight as a consequence of elevated serum PTH was explained by several mechanisms (10, 11): PTH stimulates the renal hydroxylation of 25-OH Vit D to its active form, 1,25-OH Vit D, which in turn elevates the calcium influx into adipocytes. In these cell...

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“…Furthermore, in the NOD mouse (an excellent animal model of IDDM) vitamin D3 administration prevents the development of IDDM as well as the associated autoimmune insulitis [25]. In a recent study in Bangladeshi subjects living in east London, vitamin D levels were found to be reduced in those most at risk for non-insulin-dependent diabetes [26]. Therefore, we have studied the vitamin D receptor (VDR) locus on chromosome 12q as a candidate gene for IDDM susceptibility in Southern Indian subjects using the transmission disequilibrium test (TDT) [27,28] in family trios consisting of parents and affected offspring.…”

mentioning

confidence: 99%

Allelic variation in the vitamin D receptor influences susceptibility to IDDM in Indian Asians

McDermott¹,

Ramachandran

Ogunkolade³

et al. 1997

Diabetologia

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154

106

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Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in East London Asians

Cited by 331 publications

References 28 publications

Low 25(OH)D3 levels are associated with total adiposity, metabolic syndrome, and hypertension in Caucasian children and adolescents

Low 25(OH)D3 levels are associated with total adiposity, metabolic syndrome, and hypertension in Caucasian children and adolescents

Vitamin D status and parathyroid hormone in obese children before and after weight loss

Allelic variation in the vitamin D receptor influences susceptibility to IDDM in Indian Asians

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