Glucose Intolerance and Hepatic, Biliary Tract and Pancreatic Dysfunction

Glick, Michael; Hoefs, John C.; Meshkinpour, Hooshang

doi:10.1159/000171165

Cited by 3 publications

(2 citation statements)

References 68 publications

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“…The most common lesions seen are an increase in liver glycogen leading to vacuolization in cytoplasm and hepatocyte nuclei [29]. STZ-diabetic rats have been shown to exhibit an elevated plasma ALT level without morphological changes in liver [10,11,15,16].…”

Section: Discussionmentioning

confidence: 99%

Effect of chromium picolinate on histopathological alterations in STZ and neonatal STZ diabetic rats

Shinde

Goyal

2003

J Cellular Molecular Medi

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Earlier studies from our laboratory have indicated insulin sensitizing action of chromium picolinate as the mechanism of its anti‐diabetic activity in experimental models of type I and type II diabetes. In the present investigation, we have evaluated the effects of chronic administration of chromium picolinate on the functional and histological alterations of streptozotocin (STZ)‐induced diabetes in rats. Type I diabetes was induced by intravenous injection of STZ (40 mg/kg) in adult rats, whereas, type II diabetes was induced by intraperitoneal injection of STZ (90 mg/kg) in 2‐day old rat pups which in adulthood develop abnormalities resembling type II diabetes. Chromium picolinate was administered at 8 μg/ml in drinking water for 6 weeks and was found to improve glucose tolerance and increase insulin sensitivity of STZ‐diabetic rats. This treatment decrease elevated serum creatinine and urea levels as well as elevated serum levels of hepatic enzymes of both groups of diabetic rats. Histopathological studies of kidney and liver show decrease in the intensity and incidence of vacuolations, cellular infiltration and hypertrophy of STZ and nSTZ (neonatal STZ) diabetic rats. Chronic treatment with chromium picolinate however, did not alter the normal function or morphology of control rats. Chronic chromium picolinate at the therapeutic doses that improved glucose tolerance, was observed to have no hepatotoxic or nephrotoxic potential. It was rather found to improve renal and hepatic function and to reduce abnormalities associated with STZ‐diabetes. Chromium picolinate could play an important role in the long term management of diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%

Effect of chromium picolinate on histopathological alterations in STZ and neonatal STZ diabetic rats

Shinde

Goyal

2003

J Cellular Molecular Medi

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“…116 . Η κα τάσταση αυτή έχει σαν αποτέλεσμα τη διαυγή εμφάνιση του κυτταροπλάσμα τος και τη δημιουργία κενοτοπίων στον πυρήνα του ηπατοκυττάρου 117 .…”

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Η Καθαρση Της Αντιπυρινης Στη Διερευνηση Της Ηπατικης Λειτουργιας Σε Ασθενεις Με Σακχαρωδη Διαβητη

Μανεσ¹

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Quantitative Studies of Hepatocytes in Periportal and Perivenous Zones of the Liver Lobules in Diabetic Rats

Golalipour¹,

Ghafari²

2007

International J. of Zoological Research

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Glucose Intolerance and Hepatic, Biliary Tract and Pancreatic Dysfunction

Cited by 3 publications

References 68 publications

Effect of chromium picolinate on histopathological alterations in STZ and neonatal STZ diabetic rats

Effect of chromium picolinate on histopathological alterations in STZ and neonatal STZ diabetic rats

Η Καθαρση Της Αντιπυρινης Στη Διερευνηση Της Ηπατικης Λειτουργιας Σε Ασθενεις Με Σακχαρωδη Διαβητη

Quantitative Studies of Hepatocytes in Periportal and Perivenous Zones of the Liver Lobules in Diabetic Rats

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