Glucose-insulin-potassium solution improves left ventricular mechanics in diabetes

Ramanathan, Tharumenthiran; Shirota, Kazuaki; Morita, Shin; Nishimura, Takashi; Huang, Yifei; Hunyor, Stephen N.

doi:10.1016/s0003-4975(01)03324-0

Cited by 12 publications

(8 citation statements)

References 20 publications

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“…Similar results were obtained in a study of rats, in which the administration of GIK not only before induction of ischemia but also during acute ischemia seemed beneficial for myocardial function [10]. A recent study of diabetic sheep found that GIK improved left ventricular contractility as determined by stroke work efficiency [27]. …”

Section: Discussionsupporting

confidence: 79%

The impact of glucose-insulin-potassium infusion in acute myocardial infarction on infarct size and left ventricular ejection fraction [ISRCTN56720616]

Horst

Ottervanger

Hof

et al. 2005

BMC Med

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Background: Favorable clinical outcomes have been observed with glucose-insulin-potassium infusion (GIK) in acute myocardial infarction (MI). The mechanisms of this beneficial effect have not been delineated clearly. GIK has metabolic, anti-inflammatory and profibrinolytic effects and it may preserve the ischemic myocardium. We sought to assess the effect of GIK infusion on infarct size and left ventricular function, as part of a randomized controlled trial.

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Section: Discussionsupporting

confidence: 79%

The impact of glucose-insulin-potassium infusion in acute myocardial infarction on infarct size and left ventricular ejection fraction [ISRCTN56720616]

Horst

Ottervanger

Hof

et al. 2005

BMC Med

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“…These effects extrapolated to improved systolic and diastolic function in this model. In other animal models, GIK infusion in improved left ventricular contractility, decreased tissue acidosis, and decreased infarct size (144,152,162).…”

Section: Is Insulin Per Se Therapeutic?mentioning

confidence: 97%

Management of Diabetes and Hyperglycemia in Hospitals

et al. 2004

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“…23 However, others have not been able to reproduce these results. 13,[24][25][26][27] These conflicting results may be due to the already normal function of myocardium, in which it is more difficult to enhance myocardial function than in already dysfunctional myocardium, e.g.…”

Section: Effects Of Insulin On Metabolismmentioning

confidence: 99%

The effect of insulin on the heart

Klein

Visser²

2010

NHJL

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Positive inotropic effects of insulin were described early after the isolation of insulin from the pancreas but data on the effect of insulin on the heart are conflicting. Systemic insulin administration results in a reduction in circulating free fatty acids and an improvement in myocardial glucose uptake, which causes an efficiency improvement in the myocardial cell. There is strong evidence that insulin administration results in functional improvement in dysfunctional myocardium. (Neth Heart J 2010;18:197-201.).

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Glucose-insulin-potassium solution improves left ventricular mechanics in diabetes

Cited by 12 publications

References 20 publications

The impact of glucose-insulin-potassium infusion in acute myocardial infarction on infarct size and left ventricular ejection fraction [ISRCTN56720616]

The impact of glucose-insulin-potassium infusion in acute myocardial infarction on infarct size and left ventricular ejection fraction [ISRCTN56720616]

Management of Diabetes and Hyperglycemia in Hospitals

The effect of insulin on the heart

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