Glucose, Insulin, and the Kidney

Schetz, Miet; Vanhorebeek, Ilse; Gunst, Jan; Berghe, Greet Van den

doi:10.1007/978-3-540-69441-0_19

Cited by 1 publication

(1 citation statement)

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“…The presence of glucose in the urine, together with the increase in ketone bodies, would indicate a situation of type II diabetes. Glucose transporters in the nephritic tubes are unable to recover glucose from urine because there is excess glucose that saturating the transporters (Mather & Pollock, 2011 ; Schetz et al, 2010 ; Wen et al, 2021 ). It is also important to point out that the presence of ketone bodies in urine could be due to the role that these compounds play as molecular signals and protection against kidney damage.…”

Section: Discussionmentioning

confidence: 99%

A metabolic readout of the urine metabolome of COVID-19 patients

et al. 2023

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Analysis of urine samples from COVID-19 patients by 1 H NMR reveals important metabolic alterations due to SAR-CoV-2 infection. Previous studies have identified biomarkers in urine that reflect metabolic alterations in COVID-19 patients. We have used 1 H NMR to better define these metabolic alterations since this technique allows us to obtain a broad profile of the metabolites present in urine. This technique offers the advantage that sample preparation is very simple and gives us very complete information on the metabolites present. To detect these alterations, we have compared urine samples from COVID-19 patients (n = 35) with healthy people (n = 18). We used unsupervised (Robust PCA) and supervised (PLS-LDA) multivariate analysis methods to evaluate the differences between the two groups: COVID-19 and healthy controls. The differences focus on a group of metabolites related to energy metabolism (glucose, ketone bodies, glycine, creatinine, and citrate) and other processes related to bacterial flora (TMAO and formic acid) and detoxification (hippuric acid). The alterations in the urinary metabolome shown in this work indicate that SARS-CoV-2 causes a metabolic change from a normal situation of glucose consumption towards a gluconeogenic situation and possible insulin resistance. Supplementary Information The online version contains supplementary material available at 10.1007/s11306-023-01971-6.

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Section: Discussionmentioning

confidence: 99%