1997
DOI: 10.1021/bc970128e
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Glucose-Induced Release of Glycosylpoly(ethylene glycol) Insulin Bound to a Soluble Conjugate of Concanavalin A

Abstract: Treatment of diabetes mellitus by insulin injections provides long-term control of the disease but lacks any feedback response to glucose concentration changes, which finally leads to a number of life-threatening conditions. The purpose of this study was to improve and optimize an implantable, concanavalin A (Con A) based, glucose-responsive insulin delivery system studied earlier [Jeong, S. Y., Kim, S. W., Holmberg, D. L., and McRea, J. C. (1985) J. Controlled Release 2, 143-152], which can be used for long-t… Show more

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Cited by 62 publications
(36 citation statements)
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“…Previous work toward the preparation of self-regulated insulin therapy has explored, for example, the use of glycosylated insulins in combination with glucose-binding lectins such as Con A (27)(28)(29)(30)(31). This technology has generally comprised a device, capsule, or pouch containing lectin-bound glycosylated insulin to be released as circulating glucose levels increase.…”
Section: Discussionmentioning
confidence: 99%
“…Previous work toward the preparation of self-regulated insulin therapy has explored, for example, the use of glycosylated insulins in combination with glucose-binding lectins such as Con A (27)(28)(29)(30)(31). This technology has generally comprised a device, capsule, or pouch containing lectin-bound glycosylated insulin to be released as circulating glucose levels increase.…”
Section: Discussionmentioning
confidence: 99%
“…Over the last decade, many glucose-responsive insulin delivery strategies have been exploited based on the selective binding between GBPs and glucose (Liu et al, 1997; Veiseh et al, 2015; Yu et al, 2016a). A lectin from the jack bean, concanavalin A (Con A), is commonly used as the glucose sensing moiety (Parmpi and Kofinas, 2004).…”
Section: Glucose-responsive Closed-loop Insulin Delivery Systemsmentioning
confidence: 99%
“…1, which was modified from a previously reported method [15]. To avoid cross-linking of the polymer, all carboxylic groups were activated before reactions and excess amounts of PEG and GLP-1 were added.…”
Section: Synthesis and Characterizationmentioning
confidence: 99%