Glucose-induced and ChREBP: MLX-mediated lipogenic program promotes hepatocellular carcinoma development

Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib

“…In line with these data, hepatic ChREBP overexpression reduces hepatic Gck mRNA levels (gse61576) [ 35 ], while ChREBP knockout mice show increased Gck mRNA levels [ 11 ]. Previous work showed that MLX, the binding partner of ChREBP, but not ChREBP itself, mediates glucose-mediated Gck repression in hepatocytes and mouse liver [ 10 , 13 , 41 ]. Besides increased Gck mRNA levels, shChREBP-treated mice showed elevated GCK protein levels, as well as increased cytosolic GCK/GCKR protein ratios.…”