Glucose in Nasal Secretions: Diagnostic Significance

Kosoy, J; Trieff, Norman M.; Winkelmann, Paul; Bailey, Byron J.

doi:10.1001/archotol.1972.00770080367008

Cited by 18 publications

(3 citation statements)

References 14 publications

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“…Quantitative glucose, protein, and potassium evaluations are more accurate than qualitative tests such as the glucose oxidase test. 54 Better still, β 2 transferrin is an isoform of transferrin found only in the CSF, perilymph, and aqueous humor. 55 Small volumes of CSF can therefore be used in protein electrophoresis to detect β 2 transferrin with high sensitivity and specificity for diagnosis of CSF fistula.…”

Section: Cerebrospinal Fluid Fistulaementioning

confidence: 99%

Treatment of Temporal Bone Fractures

2016

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Traumatic injury to the temporal bone can lead to significant morbidity or mortality and knowledge of the pertinent anatomy, pathophysiology of injury, and appropriate management strategies is critical for successful recovery and rehabilitation of such injured patients. Most temporal bone fractures are caused by motor vehicle accidents. Temporal bone fractures are best classified as either otic capsule sparing or otic capsule disrupting-type fractures, as such classification correlates well with risk of concomitant functional complications. The most common complications of temporal bone fractures are facial nerve injury, cerebrospinal fluid (CSF) leak, and hearing loss. Assessment of facial nerve function as soon as possible following injury greatly facilitates clinical decision making. Use of prophylactic antibiotics in the setting of CSF leak is controversial; however, following critical analysis and interpretation of the existing classic and contemporary literature, we believe its use is absolutely warranted.

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Section: Cerebrospinal Fluid Fistulaementioning

confidence: 99%

Treatment of Temporal Bone Fractures

2016

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“…Nonetheless, a glucose test is not definitive because the glucose oxidase assays used nowadays are too sensitive, turning positive even at low values of glucose; therefore, even normal nasal secretions can elicit false-positive reactions. 52,60,63 As a result, the glucose test for CSF rhinorrhea has become obsolete.…”

Section: Diagnosis Of Csf Rhinorrheamentioning

confidence: 99%

Diagnosis and treatment of cerebrospinal fluid rhinorrhea following accidental traumatic anterior skull base fractures

Ziu¹,

Savage²,

Jimenez³

2012

FOC

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Cerebrospinal fluid rhinorrhea is a serious and potentially fatal condition because of an increased risk of meningitis and brain abscess. Approximately 80% of all cases occur in patients with head injuries and craniofacial fractures. Despite technical advances in the diagnosis and management of CSF rhinorrhea caused by craniofacial injury through the introduction of MRI and endoscopic extracranial surgical approaches, difficulties remain. The authors review here the pathophysiology, diagnosis, and management of CSF rhinorrhea relevant exclusively to traumatic anterior skull base injuries and attempt to identify areas in which further work is needed.

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“…In the past, glucose testing was performed, because it was easy and it was the most available marker, but it was proved that it has poor sensitivity and specificity 25,26 Imaging methods The following step in diagnosing CSF leak, after clinical suspicion, is based on the imaging methods. After the confirmation of the CSF rhinorrhea, the next step consists in identifying its exact site and establishing the optimal treatment.…”

Section: Laboratory Testsmentioning

confidence: 99%

Current insights in CSF leaks: a literature review of mechanisms, pathophysiology and treatment options

Patrascu¹,

Manea²,

Sarafoleanu³

2017

Romanian Journal of Rhinology

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A cerebrospinal fluid (CSF) leak occurs when there appears a fistula between the dura and the skull base and it is usually characterized by discharge of cerebrospinal fluid from the nose. Cerebrospinal fluid leaks may have many etiologies, the most common being trauma. The most common site of dural lesion is the cribriform plate of the ethmoid. Diagnosis can be achieved by a multitude of techniques, high-resolution computed tomography being the modality of choice and it may be completed with magnetic resonance imaging or cisternography. Treatment may be either conservative, either surgical, related to the cause, the site and the duration of CSF leak. Conservative treatment usually includes strict bed rest, elevated bed head and no straining, nose blowing or stretching, with resolution of the majority of traumatic CSF leaks in seven days. Surgical treatment consists of a variety of approaches (intracranial/extracranial, open/endoscopic). The future trend is represented by minimally invasive endoscopic approaches, with a success rate of almost 90%; however, open transcranial or extracranial interventions still have indications in the surgical management. CSF leaks must be correctly diagnosed and treated, because the risk of intracranial complications increases 10-fold when the leakage persists.

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Glucose in Nasal Secretions: Diagnostic Significance

Cited by 18 publications

References 14 publications

Treatment of Temporal Bone Fractures

Treatment of Temporal Bone Fractures

Diagnosis and treatment of cerebrospinal fluid rhinorrhea following accidental traumatic anterior skull base fractures

Current insights in CSF leaks: a literature review of mechanisms, pathophysiology and treatment options

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