Glucose Homeostasis in the Newborn Puppy

Allen, David T.

doi:10.1001/archpedi.1966.02090130117011

Cited by 4 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In humans, it is observed that lactate works as a glucose saver and has an important role in the immediate period after birth ( 16 ). It is present in concentrations higher than normal in the first hours of life, as well as in newborn dogs ( 32 , 35 ).…”

Section: Glucose Homeostasis and The Pathophysiology Of Neonatal Hypo...mentioning

confidence: 99%

Neonatal hypoglycemia in dogs—pathophysiology, risk factors, diagnosis and treatment

Fuchs,

Pereira,

Xavier

et al. 2024

Front. Vet. Sci.

View full text Add to dashboard Cite

Hypoglycemia is the most common metabolic alteration in the clinical routine of newborn dogs, acting as a predictor of mortality in these patients. The neonatal dog shows hepatic insufficiency and homeostatic mechanisms not yet fully developed, with limited glycogen reserves and limited capacity to perform glycogenolysis and gluconeogenesis. These physiological particularities make newborn dogs particularly susceptible to hypoglycemia when of fasting, even for short periods. Several maternal and neonatal factors may be related to a higher risk of developing hypoglycemia in neonates. This paper reviews glycemic homeostasis, the pathophysiology of neonatal hypoglycemia, the main causes involved and the diagnostic and therapeutic approaches to this condition.

show abstract

Section: Glucose Homeostasis and The Pathophysiology Of Neonatal Hypo...mentioning

confidence: 99%

Neonatal hypoglycemia in dogs—pathophysiology, risk factors, diagnosis and treatment

Fuchs,

Pereira,

Xavier

et al. 2024

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…For these reasons, maintaining a temperature and adequate glucose levels is limited in the newborn puppy (Allen et al 1966). Hence, hypothermia and hypoglycemia can trigger fatal consequences (Münnich and Küchenmeister 2014).…”

Section: Accepted Articlementioning

confidence: 99%

Thermal homeostasis in the newborn puppy: behavioral and physiological responses

Reyes-Sotelo

Mota-Rojas

Martı́nez-Burnes

et al. 2021

JABB

View full text Add to dashboard Cite

Some peculiarities of the glucoregulatory response to glucose infusion in the rat

Saccà¹,

Rengo²,

Perez³

et al. 1976

Acta diabet. lat

View full text Add to dashboard Cite

The glucoregulatory response to the i.v. infusion of different doses of glucose and glucose plus insulin was studied in anesthetized rats by using the primed constant infusion of glucose-2-3H. Infusion of glucose at the rate of 10 mg/kg/min induced a rise of about 100% in blood glucose, while the hepatic release of glucose showed only a small and transient decrease. A proportional increase of glycemia and glucose utilization (Rd) was observed without any appreciable change in the metabolic clearance rate (MCR) of glucose; a two-fold increase in plasma insulin was recorded at all times. In the group of rats receiving 20 mg/kg/min of glucose, changes in the above parameters were slightly greater; MCR showed a moderate increment in spite of the six-fold rise of plasma insulin. Finally, the influsion of large doses of insulin together with 20 mg/kg/min of glucose resulted in complete cessation of glucose release by the liver and in a remarkable increase of Rd and MCR. These results suggest a poor adaptability of the glucoregulatory system of the rat in response to glucose infusion as compared to other mammalian species.

show abstract

Glucose Homeostasis in the Newborn Puppy

Cited by 4 publications

References 15 publications

Neonatal hypoglycemia in dogs—pathophysiology, risk factors, diagnosis and treatment

Neonatal hypoglycemia in dogs—pathophysiology, risk factors, diagnosis and treatment

Thermal homeostasis in the newborn puppy: behavioral and physiological responses

Some peculiarities of the glucoregulatory response to glucose infusion in the rat

Contact Info

Product

Resources

About