1995
DOI: 10.1152/ajpendo.1995.268.4.e636
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Glucose homeostasis during exercise in humans with a liver or kidney transplant

Abstract: To investigate the role of liver nerve activity on hepatic glucose production during exercise, liver-transplant subjects (LTX, n = 7, 25-62 yr, 4-18 mo postoperative) cycled for 40 min, 20 min at 52 +/- 3% (SE) maximal O2 consumption (VO2max) and 20 min at 83 +/- 1% VO2max, respectively. Kidney-transplant (KTX) and healthy control subjects (C) matched for sex and age exercised at the same %VO2max as LTX. VO2max was lower in both LTX (1.59 +/- 0.12 l/min) and KTX (1.59 +/- 0.07) than in C (2.60 +/- 0.26). At re… Show more

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Cited by 40 publications
(44 citation statements)
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“…Some data have been interpreted as inconsistent with the hypothesis of circulating catecholamine mediation of R a in IE (18,(25)(26)(27)(28)(29). Many of these may be explained by the absolute intensity of the exercise studied being lower than that which we hypothesize as the threshold above which the catecholamines become key regulators.…”
Section: Discussionmentioning
confidence: 66%
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“…Some data have been interpreted as inconsistent with the hypothesis of circulating catecholamine mediation of R a in IE (18,(25)(26)(27)(28)(29). Many of these may be explained by the absolute intensity of the exercise studied being lower than that which we hypothesize as the threshold above which the catecholamines become key regulators.…”
Section: Discussionmentioning
confidence: 66%
“…However, the subjects were exercising at Ͻ75% V O 2max , and R a increased only threefold. Another study (29) showed no significant attenuation of R a in subjects who had undergone liver transplantation, exercising at 82% V O 2max. However, the absolute intensity was quite low (only 68 vs. 108 W in our CCI subjects and ϳ260 W in our subjects exercising at 87% V O 2max [10]).…”
Section: Discussionmentioning
confidence: 92%
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“…The onset of exercise causes an increase in sympathetic activity that correlates with an increase in R a . However, studies designed to assess the role of sympathetic drive to the liver in the stimulation of R a , using chronic denervation (8), local hepatic adrenergic blockade (9,10), and liver transplant patients (presumably free of sympathetic innervation to the liver) (11), have been uniformly negative. Nevertheless, studies performed in humans using the pancreatic clamp technique and combined ␣-and ␤-adrenergic blockade suggest that epinephrine may prevent overt hypoglycemia during moderate exercise (12).…”
mentioning
confidence: 99%
“…Provision of a functional hepatic parenchyma has indeed been shown to restore many major metabolic functions of the liver. [13][14][15] The normal liver innervation, however, is irreversibly lost in the process of liver transplantation, which may possibly have unrecognized functional consequences. Liver transplant recipients frequently gain excessive amounts of body weight.…”
mentioning
confidence: 99%