Glucose enhancement of recognition memory: Differential effects on effortful processing but not aspects of ‘remember-know’ responses

Scholey, Andrew; Macpherson, Helen; Sünram-Lea, Sandra I.; Elliott, Jade M.; Stough, Con; Kennedy, David O.

doi:10.1016/j.neuropharm.2012.06.030

Cited by 18 publications

(25 citation statements)

References 45 publications

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“…However, the finding of a decrease in the SI for the dual-task condition in comparison to the single task is in accordance with previous research by Scholey et al [28] where a decrease in accuracy was also reported when an additional handmoving task was employed. In contrast to the work of Scholey et al [28] however, no interaction between task and treatment was found, failing to corroborate the theory that task effort is an important determinant of glucose facilitation. Similarly, the proportion of remember, know and guess responses were also found to be unaffected by task and condition as well as their interaction.…”

Section: Discussionsupporting

confidence: 92%

“…The finding of a lowered Sensitivity Index (SI) with glucose in comparison to placebo is in contrast to previous research by both Sünram-Lea et al [27] and Scholey et al [28] who reported a treatment effect in favour of glucose, and is also in contrast to the finding of no effect by Smith et al [32]. This finding is difficult to reconcile with current theories regarding the glucose-facilitatory effect.…”

Section: Discussioncontrasting

confidence: 92%

“…Whilst the research of Sünram-Lea et al (2008) provides support for the view that the cognitive enhancing effects of glucose are 'domain' (hippocampal) specific, a recent study from our laboratory [28] provided contrary evidence. In this study glucose was found to have no effect on the proportion of responses categorised as recollected or familiar.…”

Section: Introductionmentioning

confidence: 72%

“…In this study glucose was found to have no effect on the proportion of responses categorised as recollected or familiar. However, greater overall recognition accuracy following glucose consumption was found when a secondary hand movement task was included during word encoding [28]. These findings raise the possibility that the degree of mental effort required to complete a task, rather than hippocampal involvement, is the more important determinant of task sensitivity to glucose enhancement [28].…”

Section: Introductionmentioning

confidence: 99%

“…However, greater overall recognition accuracy following glucose consumption was found when a secondary hand movement task was included during word encoding [28]. These findings raise the possibility that the degree of mental effort required to complete a task, rather than hippocampal involvement, is the more important determinant of task sensitivity to glucose enhancement [28]. A corollary of this theory is that glucose may facilitate memory function by targeting brain regions more globally, with effects not strictly isolated to the hippocampus [10].…”

Section: Introductionmentioning

confidence: 99%

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Hippocampal involvement in glucose facilitation of recognition memory: Event-related potential components in a dual-task paradigm

Scholey

Camfield

Macpherson

et al. 2015

NUA

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Con and Riby, Leigh (2015) Hippocampal involvement in glucose facilitation of recognition memory: Event-related potential components in a dual-task paradigm. Nutrition and Aging, 3 (1 Northumbria University has developed Northumbria Research Link (NRL) to enable users to access the University's research output. Copyright © and moral rights for items on NRL are retained by the individual author(s) and/or other copyright owners. Single copies of full items can be reproduced, displayed or performed, and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided the authors, title and full bibliographic details are given, as well as a hyperlink and/or URL to the original metadata page. The content must not be changed in any way. Full items must not be sold commercially in any format or medium without formal permission of the copyright holder. The full policy is available online: http://nrl.northumbria.ac.uk/policies.html This document may differ from the final, published version of the research and has been made available online in accordance with publisher policies. To read and/or cite from the published version of the research, please visit the publisher's website (a subscription may be required.) Nutrition and Aging 3 (2015) METHODS:In this double-blind placebo-controlled cross-over study, 12 older participants (mean age = 69.33 ± 1.69 years) completed the remember-know paradigm both with and without a concurrent tracking task while recording event-related potentials (ERPs). RESULTS: Counter to predictions, glucose reduced overall accuracy. No treatment effects were found for proportion of Remember, Know and Guess responses, although there was a trend towards greater accuracy for 'Remember' responses following glucose. There was weak evidence for dissociation of drink effects on tracking with glucose being associated with preferential allocation of resources to 'Remember' over 'Know' responses. At P3 and F3 electrode sites, a significantly greater left parietal (LP) recollection effect and greater FN400 effect respectively were found for glucose. CONCLUSIONS: These findings do not support task effort modulation of the memory-enhancing effects of glucose. There was evidence of a greater glucose facilitatory effect for hippocampus-mediated LP recollection.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 92%

Section: Introductionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hippocampal involvement in glucose facilitation of recognition memory: Event-related potential components in a dual-task paradigm

Scholey

Camfield

Macpherson

et al. 2015

NUA

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Effects of two doses of glucose and a caffeine–glucose combination on cognitive performance and mood during multi‐tasking

Scholey

Savage

O’Neill

et al. 2014

Human Psychopharmacology

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BackgroundThis study assessed the effects of two doses of glucose and a caffeine–glucose combination on mood and performance of an ecologically valid, computerised multi-tasking platform.Materials and methodsFollowing a double-blind, placebo-controlled, randomised, parallel-groups design, 150 healthy adults (mean age 34.78 years) consumed drinks containing placebo, 25 g glucose, 60 g glucose or 60 g glucose with 40 mg caffeine. They completed a multi-tasking framework at baseline and then 30 min following drink consumption with mood assessments immediately before and after the multi-tasking framework. Blood glucose and salivary caffeine were co-monitored.ResultsThe caffeine–glucose group had significantly better total multi-tasking scores than the placebo or 60 g glucose groups and were significantly faster at mental arithmetic tasks than either glucose drink group. There were no significant treatment effects on mood. Caffeine and glucose levels confirmed compliance with overnight abstinence/fasting, respectively, and followed the predicted post-drink patterns.ConclusionThese data suggest that co-administration of glucose and caffeine allows greater allocation of attentional resources than placebo or glucose alone. At present, we cannot rule out the possibility that the effects are due to caffeine alone Future studies should aim at disentangling caffeine and glucose effects.

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The Role of Glycaemic Control in Cognitive Functioning

Elliott

2020

Chemically Modified Minds

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Glucose enhancement of recognition memory: Differential effects on effortful processing but not aspects of ‘remember-know’ responses

Cited by 18 publications

References 45 publications

Hippocampal involvement in glucose facilitation of recognition memory: Event-related potential components in a dual-task paradigm

Hippocampal involvement in glucose facilitation of recognition memory: Event-related potential components in a dual-task paradigm

Effects of two doses of glucose and a caffeine–glucose combination on cognitive performance and mood during multi‐tasking

The Role of Glycaemic Control in Cognitive Functioning

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