Glucose effectiveness is strongly related to left ventricular mass in subjects with stage I hypertension or high-normal blood pressure

Stiefel, Pablo; Miranda, María Luisa; Rodríguez-Puras, María J.; García-Morillo, Salvador; Carneado, J; Pamies, E.; Villar, José R.

doi:10.1016/j.amjhyper.2003.09.015

Cited by 12 publications

(11 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, the association was independent of age, degree of obesity, renal function, HTN and other potential confounding factors, including DM and HL. [23][24][25][26] This finding is consistent with the results of an experimental study that have reported allopurinol-treated rats developing significantly less cardiac hypertrophy with negligible effects on BP, 4 and is also in agreement with the current understanding of the association as observed in small samples of hypertensive patients. 5,6 We have demonstrated the association in more detail in a large sample of apparently healthy individuals not taking medication for HTN, and have also revealed a significant independent association in normotensive as well as hypertensive subjects.…”

Section: Discussionsupporting

confidence: 81%

“…The odds ratios (OR) and their 95%CI of LVH according to UA level were calculated by multivariate logistic regression analysis adjusting for known confounding factors such as age, BMI, 21 Creat 22 and HTN in addition to the institute (model 1), and by potential confounding factors such as HL 23,24 and DM (model 2). 25,26 We conducted the model-2 analysis using samples stratified by BP. We added SBP as an adjustment factor in this analysis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Uric Acid and Left Ventricular Hypertrophy in Japanese Men

Mitsuhashi

Yatsuya

Matsushita

et al. 2009

Circ J

View full text Add to dashboard Cite

Circ J 2009; 73: 667 -672 ric acid (UA) is produced in the terminal stage of purine metabolism catalyzed by xanthine oxidase, and is a primary cause of gout. The relationship between serum UA and cardiovascular diseases has been, however, controversial. [1][2][3] One recent experimental study demonstrated that allopurinol, an xanthine oxidase inhibitor, prevented cardiac hypertrophy in rats with negligible effects on blood pressure (BP). 4 In humans, an elevated blood level of UA was reportedly associated with left ventricular hypertrophy (LVH) in hypertensive patients. 5,6 However, the hypertensive state may have confounded or modified the association because it could be related to both LVH and the UA level. 7 In addition, because some antihypertensive drugs are reported to reduce LVH 8 or to affect the UA level, 5 assessing the association only in those not on hypertensive medication was warranted to clarify the role of UA as an independent risk factor for LVH. Editorial p 624The prevalence of LVH has been reported as approximately 20% in adult Japanese men. 9 LVH diagnosed by electrocardiography (ECG-LVH), as well as that diagnosed by echocardiography, is known to increase the risk of cardiovascular morbidity and mortality. [10][11][12] Although a major determinant of LVH is elevated BP, a previous report has indicated LVH in approximately 10% of the normotensive population. 13 Thus, studies to find other risk factors are warranted.In the present study, we investigated the association between UA and LVH in subjects not taking medication for hypertension (HTN). Moreover, we also investigated the association by stratifying subjects by BP, which might modify the association. Methods Study PopulationThis study used baseline data collected in 2002 for a workers' cohort study on cardiovascular diseases in Aichi, Japan. The questionnaires were returned from 7,991 people, of whom 6,651 (83.2%) expressed their written consent to the use of the information. Consent for the use of data obtained during their annual health examination and to donate residual blood samples used for the examination was obtained from 5,596 (70.0%) and 4,213 (52.7%) people, respectively. In this analysis, we first restricted the subjects to men with available information on weight, height, BP, ECG, UA and other biomarker concentrations (3,773 men), because of the small number of women with (Received July 3, 2008; revised manuscript received October 24, 2008; accepted December 3, 2008; released online February 19, 2009 Uric Acid and Left Ventricular Hypertrophy in Japanese MenHirotsugu Mitsuhashi, MD* , **; Hiroshi Yatsuya, MD*; Kunihiro Matsushita, MD* , **; Huiming Zhang, MD*; Rei Otsuka, PhD* , † ; Takashi Muramatsu, MD* , **; Seiko Takefuji, MD* , † † ;Yo Hotta, MD* , † † ; Takahisa Kondo, MD**; Toyoaki Murohara, MD**; Hideaki Toyoshima, MD* , ‡ ; Koji Tamakoshi, MD* , ‡ ‡ Background: Experimental studies have reported that allopurinol protects hypertensive rats from left ventricular hypertrophy (LVH) with negligible effects on blood ...

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Uric Acid and Left Ventricular Hypertrophy in Japanese Men

Mitsuhashi

Yatsuya

Matsushita

et al. 2009

Circ J

View full text Add to dashboard Cite

show abstract

“…More recently, decreased glucose effectiveness (but not insulin sensitivity) has been found in patients with other features of the metabolic syndrome, such as increased blood pressure and an enlarged left ventricular mass (38). Furthermore, a causeeffect relationship between elevated free fatty acids and decreased glucose effectiveness has been recently suggested in diabetic individuals (29).…”

Section: Discussionmentioning

confidence: 99%

Preserved Insulin Sensitivity and β-Cell Activity, but Decreased Glucose Effectiveness in Normal-Weight Women with the Polycystic Ovary Syndrome

Gennarelli

Rovei

Novi

et al. 2005

The Journal of Clinical Endocrinology & Metabolism

View full text Add to dashboard Cite

Insulin resistance and hyperinsulinemia are often considered intrinsic features of the polycystic ovary syndrome (PCOS). Nevertheless, conflicting results of insulin sensitivity and secretion have been obtained in the subgroup of normal-weight women with PCOS. Differences in body composition, ethnicity, and diet composition and a family history of metabolic diseases may act as confounding variables in women with PCOS. In the present study, insulin sensitivity and secretion were estimated by an iv glucose tolerance test (IVGTT), analyzed by minimal models, in 20 normal-weight healthy women with PCOS and no family history of type 2 diabetes mellitus and in 20 normally ovulating women, matched for age and body mass index. Insulin sensitivity [mean (95% confidence intervals); PCOS 4.0 (2.8 -5.1) vs. controls 4.5 (3.5-5.4) 10 Ϫ4 min Ϫ1 /U⅐ml], and insulin secretion, expressed as the acute insulin response to glucose .2) vs. controls 3.7 (3.4 -4.0) U/ml] were similar in the two groups. The women with PCOS showed an increased proportion of total body fat (PCOS 29% vs. controls 27.2%; P Ͻ 0.01). They also showed decreased glucose effectiveness, i.e. the proportion of glucose uptake independent from insulin activity [PCOS 2.6 (2.1-3.0) vs. controls 3.8 (3.0 -4.6) mg ϫ 100 min Ϫ1 ; P ϭ 0.01]. The levels of insulin sensitivity and of glucose effectiveness did not correlate in either group. Whether the isolated finding of decreased glucose effectiveness could reflect an early stage in the development of the metabolic aberrations often associated with the syndrome remains to be clarified. I NSULIN RESISTANCE IS currently considered a predominant feature of the polycystic ovary syndrome (PCOS), the most common endocrine disturbance in women of reproductive age (1). However, although a general agreement has been reached on the constant association between insulin resistance and PCOS in obese women, data are conflicting for women with PCOS in the normal-weight range (2). The euglycemic hyperinsulinemic clamp (3) is the most sensitive method for measuring insulin sensitivity in vivo, and it is considered the gold standard for research purposes. As a matter of fact, about half of the published clamp studies found preserved insulin sensitivity in normal-weight women with PCOS (4 -9), when compared with weight-matched controls, whereas the remaining studies (in particular from North America) reported some degree of insulin resistance in these patients (10 -13).However, the majority of previous studies failed to take into account the effect of confounding variables, such as ethnicity, dietary habits, a family history of type 2 diabetes mellitus, and body fat distribution (14), which could exert a strong impact on metabolism. In addition, the cutoff value in body mass index (BMI) for what is regarded as "normal weight" could vary between different studies, with important consequences on metabolic results (15).It should be noted that the euglycemic clamp has been criticized, being unable to distinguish between insulindependent and ins...

show abstract

“…Insulin and leptin both stimulate cardiac growth in isolated cardiomyocytes, suggesting that diet-induced increases in their circulating concentrations could stimulate LVH independent of afterload 3, 11, 12 . In patients with hypertension there is a positive relationship between plasma insulin concentration and LVH that is independent of blood pressure [13][14][15][16] . In addition, increased plasma leptin levels are correlated with LVH and congestive heart failure 17, 18 .…”

Section: Introductionmentioning

confidence: 99%

Low-Carbohydrate/High-Fat Diet Attenuates Pressure Overload–Induced Ventricular Remodeling and Dysfunction

Duda

O’Shea

Lei

et al. 2008

Journal of Cardiac Failure

View full text Add to dashboard Cite

show abstract

Glucose effectiveness is strongly related to left ventricular mass in subjects with stage I hypertension or high-normal blood pressure

Abstract: In this sample of nonobese and glucose-tolerant subjects with an early stage of hypertension, SG but not SI was related to LVM.

Cited by 12 publications

References 31 publications

Uric Acid and Left Ventricular Hypertrophy in Japanese Men

Uric Acid and Left Ventricular Hypertrophy in Japanese Men

Preserved Insulin Sensitivity and β-Cell Activity, but Decreased Glucose Effectiveness in Normal-Weight Women with the Polycystic Ovary Syndrome

Low-Carbohydrate/High-Fat Diet Attenuates Pressure Overload–Induced Ventricular Remodeling and Dysfunction

Contact Info

Product

Resources

About