Glucose-dependent insulinotropic polypeptide receptor knockout mice have altered bone turnover

Xie, Dongdong; Cheng, Hua; Hamrick, Mark W.; Zhong, Qing; Ding, Ke; Correa, Daniel J.; Williams, Stephen; Mulloy, Anthony L.; Bollag, Wendy B.; Bollag, Roni J.; Runner, Royce R.; McPherson, James C.; Insogna, Karl L.; Isales, Carlos M.

doi:10.1016/j.bone.2005.06.021

Cited by 151 publications

(101 citation statements)

References 31 publications

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“…This is in contradiction of what was observed in previous studies were these two parameters were increased [13,14]. Connections between fat and bone metabolism have been evidenced, with a role for adipokines in controlling bone remodeling.…”

Section: Discussioncontrasting

confidence: 90%

“…This reduction in BV/TV was accompanied by an increase in trabecular number with no differences in trabecular thickness and a reduction in trabecular separation [14]. These authors also reported a reduction in bone mineral content in older animals (3-and 5-month old) [14]. From these two studies, the overall conclusion is that the lack of GIPR signaling leads to a decrease, significant or not, in bone mass.…”

Section: Introductionmentioning

confidence: 84%

“…On the other hand, using the same GIPR-deficient model, Xie et al described a reduction in trabecular bone volume in younger animals (4-week-old) [14]. This reduction in BV/TV was accompanied by an increase in trabecular number with no differences in trabecular thickness and a reduction in trabecular separation [14]. These authors also reported a reduction in bone mineral content in older animals (3-and 5-month old) [14].…”

Section: Introductionmentioning

confidence: 96%

“…However, the number of osteoclasts was augmented at both ages [13]. On the other hand, using the same GIPR-deficient model, Xie et al described a reduction in trabecular bone volume in younger animals (4-week-old) [14]. This reduction in BV/TV was accompanied by an increase in trabecular number with no differences in trabecular thickness and a reduction in trabecular separation [14].…”

Section: Introductionmentioning

confidence: 99%

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Glucose-dependent insulinotropic polypeptide receptor deficiency leads to modifications of trabecular bone volume and quality in mice

Gaudin-Audrain¹,

Irwin²,

Mansur³

et al. 2013

Bone

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A role for the gastro-intestinal tract in controlling bone remodeling is suspected since serum levels of bone remodeling markers are affected rapidly after a meal. Glucose-dependent insulinotropic polypeptide (GIP) represents a suitable candidate in mediating this effect. The aim of the present study was to investigate the effect of total inhibition of GIP signaling on trabecular bone volume, microarchitecture and quality. We used GIP receptor (GIPR) knockout mice and investigated trabecular bone volume and microarchitecture by microCT and histomorphometry. GIPR-deficient animals at 16 weeks of age presented with a significant (20%) increase in trabecular bone mass accompanied by an increase (17%) in trabecular number. In addition, the number of osteoclasts and bone formation rate was significantly reduced and augmented, respectively in these animals when compared with wild-type littermates. These modifications of trabecular bone microarchitecture are linked to a remodeling in the expression pattern of adipokines in the GIPR-deficient mice. On the other hand, despite significant enhancement in bone volume, intrinsic mechanical properties of the bone matrix was reduced as well as the distribution of bone mineral density and the ratio of mature/immature collagen cross-links. Taken together, these results indicate an increase in trabecular bone volume in GIPR KO animals associated with a reduction in bone quality.

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Section: Discussioncontrasting

confidence: 90%

Section: Introductionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Glucose-dependent insulinotropic polypeptide receptor deficiency leads to modifications of trabecular bone volume and quality in mice

Gaudin-Audrain¹,

Irwin²,

Mansur³

et al. 2013

Bone

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show abstract

“…(3) The net effect in vivo is that elevations of GIP result in an increase in bone mass, (4) whereas the absence of GIP signaling results in significantly lower bone mass. (5,6) We have previously reported on the development and characterization of GIP-overexpressing transgenic (Tg + ) mice. (4,7) These Tg + mice have increased bone mass consistent with our in vitro data showing stimulatory GIP effects on osteoblasts and inhibitory effects on osteoclasts.…”

Section: G Lucose-dependent Insulinotropic Peptide (Gip) Ismentioning

confidence: 99%