Purpose: To provide nurse practitioners (NPs) with a review of the 2012 Standards of Care for the management of hospitalized patients who are hyperglycemic. Data sources: The 2012 American Diabetes Association's (ADA) Standards of Care for the treatment of inpatient hyperglycemia and selected evidence-based articles. Conclusions: Because hyperglycemia occurs at alarming rates in the inpatient setting when hyperglycemia is not controlled, there is a great impact on acute and even chronic conditions. These complications will lead to increased healthcare costs. Implications for practice: It is essential that NPs who care for hospitalized, hyperglycemic patients are aware of the 2012 ADA Standards of Care.Diabetes mellitus is one of the most costly chronic diseases nationwide with inpatient care cost approaching $40 billion per year (Patel & Doughty, 2008). Recently, medical science witnessed new treatments and protocols for a wide spectrum of illnesses. However, little has changed with regard to the urgency for the improvement in inpatient needs for euglycemia from 2011 to 2012. Hyperglycemia remains a very distinct problem in the inpatient population (Moghissi et al., 2009). Hence, the Diabetes Care journal includes recommendations each year on the management of this special population of patients. The recommendations are based on the American Diabetes Association (ADA) and American Association of Clinical Endocrinologists (AACE) consensus statement on glycemic control. These organizations find it necessary to establish, publish, and revisit recommendations for inpatient hyperglycemic treatment on an annual basis. The purpose of this article is to update nurse practitioners (NPs) on the changes in the 2012 Standards of Care for management of hyperglycemia in hospitalized patients.