Glucose and Insulin Induction of Bile Acid Synthesis

Li, Tiangang; Francl, Jessica M.; Boehme, Shannon; Ochoa, Adrian; Zhang, Youcai; Klaassen, Curtis D.; Erickson, Sandra K.; Chiang, John Y.L.

doi:10.1074/jbc.m111.305789

Cited by 177 publications

(90 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, oral glucose ingestion leads to increased levels of cholecystokinin, a hormone that stimulates the production of hepatic bile and gall bladder contractions (Liddle et al 1985). The link between bile acids and glucose homoeostasis was further confirmed by the demonstration of enhanced Cyp7a1 mRNA expression following insulin injection or oral glucose administration in fasting mice (Li et al 2012). Additionally, in primary human hepatocytes, insulin and glucose were shown to stimulate CYP7A1 mRNA expression (Li et al 2006(Li et al , 2010b, which suggests the existence of glucose/insulin-regulated gene transcription in the liver.…”

Section: Mmol/l) (World Health Organization 2006)mentioning

confidence: 70%

Metabolomics in diabetes research

Friedrich¹

2012

Journal of Endocrinology

124

View full text Add to dashboard Cite

Diabetes represents one of the most important global health problems because it is associated with a large economic burden on the health systems of many countries. Whereas the diagnosis and treatment of manifest diabetes have been well investigated, the identification of novel pathways or early biomarkers indicative of metabolic alterations or insulin resistance related to the development of diabetes is still in progress. Over half of the type 2 diabetes patients show manifestations of diabetes-related diseases, which highlight the need for early screening markers of diabetes. During the last decade, the rapidly growing research field of metabolomics has introduced new insights into the pathology of diabetes as well as methods to predict disease onset and has revealed new biomarkers. Recent epidemiological studies first used metabolism to predict incident diabetes and revealed branched-chain and aromatic amino acids including isoleucine, leucine, valine, tyrosine and phenylalanine as highly significant predictors of future diabetes. This review summarises the current findings of metabolic research regarding diabetes in animal models and human investigations.

show abstract

Section: Mmol/l) (World Health Organization 2006)mentioning

confidence: 70%

Metabolomics in diabetes research

Friedrich¹

2012

Journal of Endocrinology

124

View full text Add to dashboard Cite

show abstract

“…These results support an important role of FGF15, synthesized in the intestines by activation of FXR, in the regulation of CYP7A1 and bile acid synthesis in the liver. CYP7A1 has also been reported to be down-regulated by glucagon (24, 25) and pro-inflammatory cytokines (15) and up-regulated by glucose and insulin during the postprandial period (26). …”

Section: Synthesis Of Primary and Secondary Bile Acidsmentioning

confidence: 99%

Bile acids are nutrient signaling hormones

2014

View full text Add to dashboard Cite

Bile salts play crucial roles in allowing the gastrointestinal system to digest, transport and metabolize nutrients. They function as nutrient signaling hormones by activating specific nuclear receptors (FXR, PXR, Vitamin D) and G-protein coupled receptors [TGR5, sphingosine-1 phosphate receptor 2 (S1PR2), muscarinic receptors]. Bile acids and insulin appear to collaborate in regulating the metabolism of nutrients in the liver. They both activate the AKT and ERK1/2 signaling pathways. Bile acid induction of the FXR-α target gene, small heterodimer partner (SHP), is highly dependent on the activation PKCζ, a branch of the insulin signaling pathway. SHP is an important regulator of glucose and lipid metabolism in the liver. One might hypothesize that chronic low grade inflammation which is associated with insulin resistance, may inhibit bile acid signaling and disrupt lipid metabolism. The disruption of these signaling pathways may increase the risk of fatty liver and non-alcoholic fatty liver disease (NAFLD). Finally, conjugated bile acids appear to promote cholangiocarcinoma growth via the activation of S1PR2.

show abstract

“…Одержані нами дані за моделювання цу-крового діабету алоксаном вказують на те, що, крім істотних змін, у вуглеводному та ліпідному обміні, що частково підтвердилися нашими дослідженнями і були виявлені раніше іншими авторами [11][12][13], відбуваються значні перебу-дови в різних ланках біосинтезу та кон'югації ЖК. це, зокрема, виявилось у зниженні рівня таурохолевої та глікохолевої кислот у жовчі щурів з алоксаніндукованим діабетом з одно-часним зростанням суми ТХДХК та ТДХК, що вказує на певну специфіку впливу цього препа-рату на різні ланки процесів кон'югації.…”

Section: результати та обговоренняunclassified

Correlations of bile acids in the bile of rats in conditions of alloxan induced diabetes melitus

Danchenko¹

2014

Ukr.Biochem.J.

View full text Add to dashboard Cite

Glucose and Insulin Induction of Bile Acid Synthesis

Cited by 177 publications

References 41 publications

Metabolomics in diabetes research

Metabolomics in diabetes research

Bile acids are nutrient signaling hormones

Correlations of bile acids in the bile of rats in conditions of alloxan induced diabetes melitus

Contact Info

Product

Resources

About