2022
DOI: 10.1097/wnr.0000000000001820
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Glucose and fructose directly stimulate brain-derived neurotrophic factor gene expression in microglia

Abstract: Brain-derived neurotrophic factor (BDNF) is expressed in both hypothalamic neurons and microglia, and plays a critical role in the regulation of metabolism. Although hypothalamic expression of BDNF is regulated by metabolic signals such as nutrients and hormones, it remains unknown whether these signals differentially regulate BDNF expression in different cell types. The present study aimed to determine whether glucose and fructose regulate BDNF expression in microglia via the specific glucose transporter. To … Show more

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“…The decreased glucose metabolism in AD may be due to the dysfunction of those glucose transporters expressed in the BBB, choroid plexus and ependyma [95,96]. Interestingly, high glucose or fructose concentration can directly stimulate the expression of brainderived neurotrophic factor (BDNF) in the mouse microglia SIM-A9 cell [97]. Besides Aβ accumulation, more activated microglia have also been reported in AD animal models and in patients [98,99].…”
Section: Ependymal Dysfunctions In the Pathogenesis Of Neurodegenerat...mentioning
confidence: 99%
“…The decreased glucose metabolism in AD may be due to the dysfunction of those glucose transporters expressed in the BBB, choroid plexus and ependyma [95,96]. Interestingly, high glucose or fructose concentration can directly stimulate the expression of brainderived neurotrophic factor (BDNF) in the mouse microglia SIM-A9 cell [97]. Besides Aβ accumulation, more activated microglia have also been reported in AD animal models and in patients [98,99].…”
Section: Ependymal Dysfunctions In the Pathogenesis Of Neurodegenerat...mentioning
confidence: 99%