Glucose absorption in relation to ATP content of the small-intestine mucosa in the dog

Várró, V.; Jung, In-Hyun; Szarvas, F; Csernay, L.

doi:10.1007/bf02236671

Cited by 14 publications

(3 citation statements)

References 5 publications

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“…These authors explain malabsorption in this period with a lack of enzyme production. A direct correlation between glucose absorption and adenosintriphosphatase content of the mucosa has been found by others too [10,21].…”

Section: Discussionmentioning

confidence: 91%

“…1) and described by Carlson and Wangensteen [5], also by Texter's [20] statem ent that absorption deteriorates with the decrease of m esenterial circulation and by the observation of Varm el al. [21] th at a decrease in blood flow causes a disturbance of Enzyme Activity in Malabsorption during Gastrointestinal Paresis 41 adenosintriphosphatasc resynthesis which influences the absorption of glucose. The assumption about the role of microcirculatory disturb ances requires further study.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Changes of Structure and Enzyme Activity in Malabsorption during Gastrointestinal Paresis

Póka¹,

Czirbusz²,

Földi³

et al. 1968

Digestion

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Changes of Structure and Enzyme Activity in Malabsorption during Gastrointestinal Paresis

Póka¹,

Czirbusz²,

Földi³

et al. 1968

Digestion

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“…Within minutes of ischemia onset, morphologic changes begin at the mucosal level, the layer most sensitive to a hypoxic insult (1). As storage time increases, progressive compromise and eventual loss of the mucosa occurs, resulting in violation of its barrier function (2) and absorptive capacity (3). The SB graft simultaneously becomes susceptible to bacterial translocation (4, 5) and increased antigenic stimulus.…”

Section: Introductionmentioning

confidence: 99%

Defining the Role of a Tailored Luminal Solution for Small Bowel Preservation

Fujimoto¹,

Olson²,

Madsen³

et al. 2002

American Journal of Transplantation

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The mucosal layer is the initial site of small bowel (SB) graft injury sustained during cold storage. Vascular administration of preservation solutions alone is unable to prevent ischemic injury of this layer during clinically relevant storage periods. The SB is unique in that it possesses both a vascular and a luminal route by which preservation solutions can be administered. We hypothesized that addition of a luminal-delivered solution, formulated on amino acid requirements for energy-and non-energy-related reactions, would provide site-specific preservation of mucosal energetics, barrier function and morphology throughout an extended period of cold storage. Of the three luminal solutions containing amino acids which were tested (UWG, AA1, AA2), only the two groups (AA1, AA2), containing glutamine plus 18 other amino acids, ∫osmotic agent (lactobionate) and buffer (BES), exhibited significant improvements in energetics, barrier function, and histology compared to the clinical standard of isolated vascular University of Wisconsin (UW) solution. Although the AA1 and AA2 groups preserved barrier function and morphology up to 24 h better than all other solutions tested, AA2 proved to be the only luminal solution with values of permeability, conductance, and short-circuit current not significantly different from freshly isolated tissues. Furthermore, the greatest reduction in histologic injury was effected by AA2 treatment (median grade 2 compared to control, UW (v) , grade 8). This study documents that a luminaldelivered solution, formulated on physiologic SB requirements, provides targeted preservation of the SB mucosa.

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Factors regulating the disposal of an oral glucose load in normal, diabetic, and obese subjects

Waldhäusl

Bratusch-Marrain

1987

Diabetes Metab. Rev.

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Glucose absorption in relation to ATP content of the small-intestine mucosa in the dog

Cited by 14 publications

References 5 publications

Changes of Structure and Enzyme Activity in Malabsorption during Gastrointestinal Paresis

Changes of Structure and Enzyme Activity in Malabsorption during Gastrointestinal Paresis

Defining the Role of a Tailored Luminal Solution for Small Bowel Preservation

Factors regulating the disposal of an oral glucose load in normal, diabetic, and obese subjects

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