Glucose-6-Phosphate Dehydrogenases: The Hidden Players of Plant Physiology

Abstract

Glucose-6-phosphate dehydrogenase (G6PDH) catalyzes a metabolic hub between glycolysis and the pentose phosphate pathway (PPP), which is the oxidation of glucose-6-phosphate (G6P) to 6-phosphogluconolactone concomitantly with the production of nicotinamide adenine dinucleotide phosphate (NADPH), a reducing power. It is considered to be the rate-limiting step that governs carbon flow through the oxidative pentose phosphate pathway (OPPP). The OPPP is the main supplier of reductant (NADPH) for several “reducing” biosynthetic reactions. Although it is involved in multiple physiological processes, current knowledge on its exact role and regulation is still piecemeal. The present review provides a concise and comprehensive picture of the diversity of plant G6PDHs and their role in seed germination, nitrogen assimilation, plant branching, and plant response to abiotic stress. This work will help define future research directions to improve our knowledge of G6PDHs in plant physiology and to integrate this hidden player in plant performance.

Unraveling the Mechanisms of Efficient Phosphorus Utilization in Popcorn (Zea mays L. var. everta): Insights from Proteomic and Metabolite Analysis

“…In L80 only a few redox related proteins were upregulated (Tables and S3). A peroxidase (K7VCN5), already well-known to participate in antioxidant defense in response to abiotic stresses, − a glucose-6-phosphate 1-dehydrogenase (C0PIW1), first key enzyme in the oxidative pentose phosphate pathway (OPPP) producing NADPH , to maintain the oxidative–reductive balance, , and amine oxidase (AO, K7U2E4). AO is associated with the oxidation of polyamine (PA) into reactive oxygen species (ROS) responsible for oxidative stress.…”

Application of slow-controlled release fertilizer coordinates the carbon flow in carbon-nitrogen metabolism to effect rice quality

“…N-nutrient/metabolites and carbon metabolism are intricately interconnected (Yamakawa and Hakata, 2010). Carbon metabolism plays a critical role in incorporating nitrogen into cell metabolism, primarily through the oxidative pentose phosphate pathway (OPPP) and glycolysis/ the tricarboxylic acid (TCA) cycle (Bussell et al, 2013; Yang et al, 2016; Wang et al, 2021a; Jiang et al, 2022b). When comparing various types of slow-controlled release fertilizers, it was found that the application of PCU and BBF fertilizers led to a higher capacity for sucrose unloading and nitrogen assimilation (Figures.…”

Structural basis of the allosteric regulation of cyanobacterial glucose-6-phosphate dehydrogenase by the redox sensor OpcA

“…In photosynthetic organisms, G6PDH is especially needed during the night and certain nutritional conditions (e.g. resuscitation from nitrogen starvation), when glucose catabolism is the sole source of energy and metabolites (3). Thus, G6PDH is mostly active under such environmental contexts and less active during photoautotrophic growth.…”