Glucose 6‐phosphate dehydrogenase variants increase NADPH pools for yeast isoprenoid production
Sri Harsha Adusumilli,
Anuthariq Alikkam Veetil,
Chinmayee Choudhury
et al.
Abstract:Isoprenoid biosynthesis has a significant requirement for the co‐factor NADPH. Thus, increasing NADPH levels for enhancing isoprenoid yields in synthetic biology is critical. Previous efforts have focused on diverting flux into the pentose phosphate pathway or overproducing enzymes that generate NADPH. In this study, we instead focused on increasing the efficiency of enzymes that generate NADPH. We first established a robust genetic screen that allowed us to screen improved variants. The pentose phosphate path… Show more
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