Glucose-6-phosphate dehydrogenase (G6PD) deficiency

Chan, Tai-kwong.; 陳棣光,

doi:10.5353/th_b3198117

Cited by 15 publications

(26 citation statements)

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“…[1][2][3][4][5][6][9][10][11][12][13] In the present series, G-6-PD deficiency occurred in 34.9% of the patients. This was significantly higher than the reported incidence of G-6-PD deficiency of 18% to 20% in Saudi Arabia.…”

Section: Discussionmentioning

confidence: 87%

“…This may partly explain the better prognosis in the jaundiced G-6-PD-deficient infants in the present series when compared with reports from other neonatal jaundice documented in G-6-PD-deficient babies exposed to fava beans through breastfeeding. 9,13 The only baby with G-6-PD deficiency and exposure to fava beans also had Staphylococcus aureus septicemia. Fava beans 13 and septicemia 12 are capable of producing severe jaundice in such babies.…”

Section: Discussionmentioning

confidence: 99%

“…9,13 The only baby with G-6-PD deficiency and exposure to fava beans also had Staphylococcus aureus septicemia. Fava beans 13 and septicemia 12 are capable of producing severe jaundice in such babies. No single case of exposure to naphthalene was documented here.…”

Section: Discussionmentioning

confidence: 99%

“…Neonatal jaundice (NNJ) is a common cause of neonatal morbidity and mortality in many parts of the world, [1][2][3][4][5][6][9][10][11][12][13] In the present study, an average of 26 infants with moderate to severe NNJ were admitted to QCH per year. The common factors associated with jaundice in this series were G-6-PD deficiency and ABO incompatibility.…”

Section: Discussionmentioning

confidence: 99%

“…[11][12][13] It is important, therefore, to continue to document the etiology and magnitude of the problem of severe NNJ in different parts of the world, as this may help to identify ways of preventing it.…”

mentioning

confidence: 99%

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Neonatal Jaundice in Qatif: The Role of Glucose-6-Phosphate Dehydrogenase Deficiency in the Etiology Among Outpatient Cases

Al-Dabbous

Owa

Al-Khater

1995

Annals of Saudi Medicine

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, this prospective study on neonatal jaundice was carried out in Qatif Central Hospital. A total of 132 neonates with jaundice (26 per year) were admitted into the pediatric medical ward. Glucose-6-phosphate dehydrogenase deficiency (34.9%) and ABO incompatibility (24.2%) were the main associated factors. Septicemia and exposure to icterogenic agents were not common. In 40.2%, there were no associated factors. Of the 132 mothers, 93.9% were breast-feeding. Mean peak bilirubin levels and lowest hemoglobin values were similar in all the groups. There was no case with kernicterus or death. We concluded that since glucose-6-phosphate dehydrogenase deficiency was the most common factor associated with neonatal jaundice, further evaluation of the role of icterogenic agents in the etiology of jaundice in glucose-6-phosphate dehydrogenase-deficient neonates is needed. Meanwhile, parents must be educated on the dangers of exposing their babies to fava beans, naphthalene and other icterogenic agents.Neonatal jaundice (NNJ) is a worldwide problem, occurring in all races. In the USA, it occurs in 60% to 80% of neonates in the first week of life.1 Causes of NNJ vary in different parts of the world. In term infants, glucose-6-phosphate dehydrogenase (G-6-PD) deficiency was reported as a common cause of severe NNJ and kernicterus in Nigeria, 2,3 Sardinia, 4 and Southeast Asia. 5,6 In Saudi Arabia, hemoglobinopathies and G-6-PD deficiency are common. 7,8 In some parts of the world where G-6-PD deficiency is commonly associated with NNJ, environmental factors may play an important role in the pathogenesis of severe neonatal hyperbilirubinemia.4 -6 -910 Neonatal jaundice will continue to be an important research subject because of the potential risk of damage to the neonatal brain (kernicterus) in association with severe unconjugated hyperbilirubinemia. [11][12][13] It is important, therefore, to continue to document the etiology and magnitude of the problem of severe NNJ in different parts of the world, as this may help to identify ways of preventing it.In this prospective study, the associated etiological and environmental factors of jaundice in all neonates admitted to Qatif Central Hospital (QCH) from outside with jaundice were evaluated. To the best of our knowledge, this is the first report on NNJ from Saudi Arabia. Patients and SubjectsThe study was conducted prospectively between January 1989 and December 1993. All neonates admitted from outside into QCH with jaundice during this period were studied. For each patient, place of antenatal care (ANC) and delivery, gestational age (GA), birth weight (BW), sex, duration of jaundice, weight, other associated symptoms (like poor feeding, fever), condition of the umbilical slough, rectal temperature, method of feeding and the status of primitive reflexes were recorded.On admission, routine serum bilirubin (SBR), complete blood count (CBC), blood group (baby and mother) Coombs' test and G-6-PD screening test were done. In neonates with suspected sepsis, either from the condition o...

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Neonatal Jaundice in Qatif: The Role of Glucose-6-Phosphate Dehydrogenase Deficiency in the Etiology Among Outpatient Cases

Al-Dabbous

Owa

Al-Khater

1995

Annals of Saudi Medicine

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Uncovering an undisclosed diagnosis: a glucose‐6‐phosphate dehydrogenase deficiency diagnosis in a critically ill adult

Kasturiarachi,

Robinson,

Karkoska

et al. 2024

eJHaem

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Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency affects over 400 million people worldwide. The most common variant of G6PD deficiency in the United States is the A‐variant, which is present amongst African‐Americans. Most people with this variant, however, do not experience severe hemolysis unless under extreme circumstances. Here, we present the case of a 44‐year‐old African‐American male who under circumstances of multiple admissions for critical illness eventually presented with a masked diagnosis of G6PD deficiency.

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Glucose-6-phosphate dehydrogenase deficiency among neonates with jaundice in Africa; systematic review and meta-analysis

Kassahun

Tunta

Abera

et al. 2023

Heliyon

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Glucose-6-phosphate dehydrogenase (G6PD) deficiency

Cited by 15 publications

References 0 publications

Neonatal Jaundice in Qatif: The Role of Glucose-6-Phosphate Dehydrogenase Deficiency in the Etiology Among Outpatient Cases

Neonatal Jaundice in Qatif: The Role of Glucose-6-Phosphate Dehydrogenase Deficiency in the Etiology Among Outpatient Cases

Uncovering an undisclosed diagnosis: a glucose‐6‐phosphate dehydrogenase deficiency diagnosis in a critically ill adult

Glucose-6-phosphate dehydrogenase deficiency among neonates with jaundice in Africa; systematic review and meta-analysis

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