Glucose-6-phosphate dehydrogenase – from oxidative stress to cellular functions and degenerative diseases

Ho, Hung‐Yao; Cheng, Mei‐Ling; Chiu, Daniel T.

doi:10.1179/135100007x200209

Cited by 125 publications

(97 citation statements)

References 88 publications

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“…These adaptations may result from cumulative effects of repeated exercise bouts on the gene expression of antioxidant enzymes as on exercise-induced modulation of antioxidant defence (13,14). In conclusion we suggest that regular, long-term physical exercise cause adaptations in antioxidant defences.…”

Section: Discussionmentioning

confidence: 72%

Effect of a 12-Week Training Program on Levels of Glucose-6-Phosphate Dehydrogenase and Antioxidant Activity

Kaldırımcı

2010

Turk J Rheumatol

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ÖzetAmaç: Bu çalışmanın amacı basketbol oyuncularında 12 haftalık aerobik egzersiz programının G6PD aktivitesi, glutation peroksidaz ve glutation S transveraz seviyeleri üzerine etkisi olup olmadığını araştırmak idi. Yöntem ve Gereçler: Başlangıç değerleri için basketbol oyuncuları ve sedanter yaş ve cins benzer sağlıklı kontroller için kan örnekleri alındı. Plazma glutation peroksidaz, glutation S transveraz ve G6PD aktiviteleri kitlerle değerlendirildi daha sonra basketbol oyuncularına 12 haftalık egzersiz programı uygulandı. Antrenman öncesi ve antrenman sonrası değerler tüm gruplarda karşılaştırıldı. Bulgular: Antrenman programından önce glutation peroksidaz, glutation S transveraz ve G6PD aktiviteleri basketbol oyuncuların-da sedanter kontrollerden anlamlı olarak yüksekti (p<0.05, p<0.05, p<0.001). Antrenman programından sonra G6PD aktiviteleri, glutation peroksidaz,glutation S transveraz seviyeleri anlamlı olarak artmıştı (p<0.05, p<0.01, p<0.01). G6PD aktivitesi ve glutation peroksidaz,glutation S transveraz seviyeleri arasında pozitif bir korelasyon bulundu. Sonuç: Sonuç olarak biz uzun süreli fiziksel egzersizlerin G6PD ve antioksidan aktiviteleri artırdığını ve antioksidan defansda adaptasyonlara neden olduğunu söyleyebiliriz. Abst ractObjective: It has been suggested that regular, long-term exercise increases erythrocyte glucose-6-phosphate dehydrogenase (G6PD) and antioxidant enzymatic activities. The purpose of this study was to investigate whether G6PD activity and antioxidant activities consisting of glutathione peroxidase (GPX) and glutathione s transferase (GST) levels changed with a 12 week aerobic exercise program in basketball players. Materials and Methods:For baseline values, blood samples were obtained from basketball players and age and sex matched sedentary healthy volunteers. Plasma GPX, GST levels and G6PD activities were evaluated with commercial kits. Then, a 12 week training program was performed for basketball players. Pre training and post training values were compared within all groups. Results: Before training program, GPX, GST levels and G6PD activities were significantly higher in basketball players than sedentary controls (p<0.05, p<0.05, p<0.001, respectively). Also G6PD activities and GPX, GST levels were significantly increased after training program. (p<0.05, p<0.01, p<0.01, respectively). A positive correlation was found between G6PD activity and GPX, GST levels. Conclusion: Our results suggest that long term-regular physical exercise increases G6PD activity and antioxidant activities and cause adaptations in antioxidant defences. (Turk J Rheumatol 2010; 25: 34-6)

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Section: Discussionmentioning

confidence: 72%

Effect of a 12-Week Training Program on Levels of Glucose-6-Phosphate Dehydrogenase and Antioxidant Activity

Kaldırımcı

2010

Turk J Rheumatol

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“…The role of the regeneration of glutathione in the protection of erythrocytes against redox-cycling xenobiotics generating oxidative stress is evident in favism. In this case, an inborn deficiency of glucose 6-phosphate dehydrogenase activity leads to erythrocyte destruction upon exposure to fava beans or certain drugs [1,2]. By contrast, no significant anomalies in physiological erythrocyte functions have been reported in acatalasemia [3,4] and glutathione reductase deficiency [4].…”

Section: Introductionmentioning

confidence: 99%

The effects of superoxide dismutase knockout on the oxidative stress parameters and survival of mouse erythrocyt

Grzelak¹,

Kruszewski²,

Macierzyńska³

et al. 2009

Cellular and Molecular Biology Letters

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Abstract:The erythrocytes of 12-month old Sod1 -/-mice showed an increased level of reactive oxygen species (ROS), as estimated by the degree of dihydroethidine and dihydrorhodamine oxidation, and the increased level of Heinz bodies. No indices of severe oxidative stress were found in the red blood cells and blood plasma of Sod1 -/-mice as judged from the lack of significant changes in the levels of erythrocyte and plasma glutathione, plasma protein thiol and carbonyl groups and thiobarbituric-acid reactive substances in the blood plasma. However, a decreased erythrocyte lifespan, increased reticulocyte count and splenomegaly were noted, indicating the importance of superoxide dismutase for maintaining erythrocyte viability. The levels of erythrocyte ROS and Sod1 +/-mice, suggesting that a superoxide dismutase activity decrease to half of its normal value may be sufficient to secure the protective effects of the enzyme.

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“…NADPH is important for the removal of ROS and prevention of cell damage [37,38]. ROS is stimulated by high glucose levels, which damages the nucleus by linking with DNA and RNA.…”

Section: Discussionmentioning

confidence: 99%

Impact of Diabetes Mellitus Type 2 in the Activity of Glucose-6-Phosphate Dehydrogenase in Human Erythrocyte

Hamzah

Hamza²,

Rahman

2018

KJAR

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-Diabetes mellitus is a metabolic affliction saunter that is characterized by a nobler than normal blood glucose poise. Glucose-6-phosphate dehydrogenase (G6PD) enzyme code (E.C.1.1.1.49) is an underlying enzyme in the phosphogluconate pathway. In this study, G6PD vitality in the mortal erythrocyte of male and female patients with type 2 diabetes mellitus was assessed utilizing a spectrophotometer at 340 nm. The activity of the enzyme increased with elevated glycated haemoglobin (HbA1C) levels. G6PD activity was found to be significantly associated with type 2 diabetes mellitus. The association between G6PD and diabetes mellitus was significant (P < 0.001). Moreover, G6PD was positively correlated with HbA1C levels (r = 0.572). The following mean ± standard deviation values were obtained: G6PD activity (IU/g Hb), 3.1103 ± 0.79349; HbA1C (%), 8.6600 ± 1.63120; Hb (g/dL), 13.4933 ± 1.38836; platelet count (103/µl), 283.4667 ± 58.59312; WBC (103/µl), 7.4890 ± 1.49842; HCT (%), 45.0100 ± 2.63430; and BS (mg/dL), 230.2667 ± 75.67760. The results showed that an elevated HbA1C up leads to increased G6PD performance in the human erythrocyte, which is concerning to glucose levels in the special (blood).

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Glucose-6-phosphate dehydrogenase – from oxidative stress to cellular functions and degenerative diseases

Cited by 125 publications

References 88 publications

Effect of a 12-Week Training Program on Levels of Glucose-6-Phosphate Dehydrogenase and Antioxidant Activity

Effect of a 12-Week Training Program on Levels of Glucose-6-Phosphate Dehydrogenase and Antioxidant Activity

The effects of superoxide dismutase knockout on the oxidative stress parameters and survival of mouse erythrocyt

Impact of Diabetes Mellitus Type 2 in the Activity of Glucose-6-Phosphate Dehydrogenase in Human Erythrocyte

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