Glucose-6-phosphate dehydrogenase deficiency and carboxyhemoglobin concentrations associated with bilirubin-related morbidity and death in Nigerian infants

Severe hemolysis with normal blood count in a glucose-6-phosphate dehydrogenase deficient neonate

“…COHb studies in the present case as well as in those previously reported 16,17 confirm that hemolysis is a major factor in the production of the icterus. The reason that even a moderate degree of hemolysis may result in extreme hyperbilirubinemia may be due to diminished bilirubin conjugation found in G-6-PD deficient neonates compared with G-6-PD adequate controls.…”

Early Neonatal Bilirubin, Hematocrit, and Glucose-6-Phosphate Dehydrogenase Status

“…[1][2][3][4] A previous study in Nigeria identified G6PD deficiency in up to 62% of infants admitted from home with severe neonatal jaundice and kernicterus. 4 In the current study, the …”

“…This observation supports the findings of earlier studies evaluating the role of hemolysis in the etiology of hyperbilirubinemia in G6PD-deficient neonates. 4,14 Indeed, the day 0 to 8 hematocrit decline, coupled with impaired bilirubin conjugation, may partly explain the higher rate of increase in TSB among the G6PD-deficient and G6PD-intermediate neonates not exposed to known icterogenic agents. 6,16,17 This is even more so, bearing in mind that a small fall in hematocrit may result in a significant rise in bilirubin, as each gram of hemoglobin broken down produces up to 35 mg of bilirubin.…”

“…[1][2][3][4] In 1 study, G6PD deficiency was identified in up to 62% of infants with kernicterus. 4 Most of those neonates who had G6PD deficiency and kernicterus were admitted from home with a history of inadvertent previous exposure to known icterogenic agents. 5 In contrast, less is known about the pattern of bilirubin in relation to G6PD status per se.…”

Hemolysis and Hyperbilirubinemia in an African American Neonate Heterozygous for Glucose-6-Phosphate Dehydrogenase Deficiency

“…11 Kaplan and Hammerman 12 have recently drawn the attention of pediatricians to the potential dangers of hyperbilirubinemia in G6PD-deficient African American neonates in North America. In addition, in an informal kernicterus registry, Johnson and Brown 13 reported 18 of 80 (22.5%) affected neonates to have G6PD deficiency.…”