Glucosamine Supplementation Improves Physical Performance in Trained Mice

Rosa, Adrián De la; Olaso‐González, Gloria; García-Domínguez, Esther; Mastaloudis, Angela; Hester, Shelly N.; Wood, Steven; Viña, José

doi:10.1249/mss.0000000000002821

Cited by 4 publications

(1 citation statement)

References 38 publications

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“…Consistently, activating the HBP pathway might have beneficial effects on neuromuscular function. Indeed, GlcN supplementation has been described to improve motor coordination in mice (de La Rosa et al, 2022 ). However, we did not observe differences in coordination and fitness upon GlcNAc feeding or genetic HBP activation.…”

Section: Discussionmentioning

confidence: 99%

Hexosamine pathway activation improves memory but does not extend lifespan in mice

et al. 2022

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Glucosamine feeding and genetic activation of the hexosamine biosynthetic pathway (HBP) have been linked to improved protein quality control and lifespan extension. However, as an energy sensor, the HBP has been implicated in tumor progression and diabetes. Given these opposing outcomes, it is imperative to explore the long‐term effects of chronic HBP activation in mammals. Thus, we asked if HBP activation affects metabolism, coordination, memory, and survival in mice. N‐acetyl‐D‐glucosamine (GlcNAc) supplementation in the drinking water had no adverse effect on weight in males but increased weight in young females. Glucose or insulin tolerance was not affected up to 20 months of age. Of note, we observed improved memory in young male mice supplemented with GlcNAc. Survival was not changed by GlcNAc treatment. To assess the effects of genetic HBP activation, we overexpressed the pathway's key enzyme GFAT1 and a constitutively activated mutant form in all mouse tissues. We detected elevated levels of the HBP product UDP‐GlcNAc in mouse brains, but did not find any effects on behavior, memory, or survival. Together, while dietary GlcNAc supplementation did not extend survival in mice, it positively affected memory and is generally well tolerated.

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Section: Discussionmentioning

confidence: 99%

Hexosamine pathway activation improves memory but does not extend lifespan in mice

et al. 2022

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An update on the review of microbial synthesis of glucosamine and N-acetylglucosamine

Yang

Wang

Yao

et al. 2023

World J Microbiol Biotechnol

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No Associations Between Glucosamine Supplementation and Dementia or Parkinson’s Disease: Findings From a Large Prospective Cohort Study

Chen

Cai

et al. 2023

The Journals of Gerontology: Series A

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Background We investigated the associations between habitual use of glucosamine and incident dementia and Parkinson’s disease in a population-based cohort. Methods Using the UK Biobank data, we included around 0.29 million middle- to old-aged participants free of dementia or Parkinson’s disease at baseline. Glucosamine supplementation was measured by questionnaire at baseline. Some participants additionally answered one-to-five rounds of 24-h dietary recalls afterwards, particularly 112,243 (for dementia) and 112, 084 participants (for Parkinson’s disease). Incident cases of dementia and Parkinson’s disease were identified through linkage to health administrative datasets. We examined the associations of glucosamine supplementation with incident dementia and Parkinson’s disease using Cox proportional-hazards regression models with adjustment for various covariates. Results During the study period (median follow-up: 9.1~10.9 years), 4,404 and 1,637 participants developed dementia and Parkinson’s disease, respectively. Glucosamine intake was not associated with incident dementia or Parkinson’s disease. In fully adjusted models, the hazard ratios associated with glucosamine were 1.06 [95% confidence interval (CI): 0.99, 1.14] for dementia and 0.97(95% CI: 0.86, 1.09) for Parkinson’s disease. In the subsample, similar results were found as the frequency of reported glucosamine use over multiple dietary surveys was associated with neither of the two conditions. Conclusions Habitual supplementation of glucosamine was not associated with incident dementia or Parkinson’s disease.

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Glucosamine Supplementation Improves Physical Performance in Trained Mice

Abstract: Supplemental digital content is available in the text.

Cited by 4 publications

References 38 publications

Hexosamine pathway activation improves memory but does not extend lifespan in mice

Hexosamine pathway activation improves memory but does not extend lifespan in mice

An update on the review of microbial synthesis of glucosamine and N-acetylglucosamine

No Associations Between Glucosamine Supplementation and Dementia or Parkinson’s Disease: Findings From a Large Prospective Cohort Study

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