Glucosamine oral administration as an adjunct to hyaluronic acid injection in treating temporomandibular joint osteoarthritis

Cen, Xiao; Liu, Yan; Wang, Shasha; Yang, Xianrui; Shi, Zhijun; Liang, Xin‐hua

doi:10.1111/odi.12760

Cited by 16 publications

(25 citation statements)

References 34 publications

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“…In phase 2, a full‐text reading was performed, and three studies matched the inclusion criteria . From studies not considered for inclusion, 1 was excluded because the full text was not available, while other eight did not meet the inclusion criteria . A full description of reasons for exclusion is presented in Appendix .…”

Section: Resultsmentioning

confidence: 99%

Effects of glucosamine supplements on painful temporomandibular joint osteoarthritis: A systematic review

Melo

Casett

Stuginski‐Barbosa

et al. 2018

J of Oral Rehabilitation

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The purpose of this study was to systematically review the literature for studies that assessed the effects of glucosamine supplements (GS) on pain and maximum mouth opening (MMO) restriction compared to other therapies, placebo or no intervention on painful temporomandibular joint osteoarthritis (TMJ OA). Randomised controlled trials were selected in a two-phase process. Seven electronic databases, in addition to three grey literature databases, were searched. Risk of bias was assessed using the Cochrane Collaboration's tool for assessing risk of bias in randomised trials. Twelve potentially eligible studies were identified, from which three were finally included. Furthermore, two were categorised at low risk and one at high risk of bias. Intervention groups were treated with glucosamine-sulphate, while controls were treated with placebo or ibuprofen. In two studies, GS were equally effective regarding pain reduction and mouth opening improvement compared to ibuprofen taken two or three times a day over 12 weeks; however, one study did not find significant differences in follow-up evaluations concerning these clinical variables in both glucosamine and placebo groups administered over six weeks. There is very low evidence regarding GS therapeutic effects on TMJ OA. Considering a follow-up of 12 weeks, GS were as effective as ibuprofen taken two or three times a day. However, over six weeks of medication intake, GS were not superior to placebo. Still, included studies presented major drawbacks, and therefore, conclusions must be interpreted with caution.

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Section: Resultsmentioning

confidence: 99%

Effects of glucosamine supplements on painful temporomandibular joint osteoarthritis: A systematic review

Melo

Casett

Stuginski‐Barbosa

et al. 2018

J of Oral Rehabilitation

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“…A chemopreventive action of glucosamine has also been reported in lung cancer [57]. Mechanistically, the anti-inflammatory activity of glucosamine has been linked to reduction of proinflammatory cytokines such as IL-6 or IL-1β [58].…”

Section: Glucosamine and Sucralosementioning

confidence: 96%

Antitumoral Properties of the Nutritional Supplement Ocoxin Oral Solution: A Comprehensive Review

2020

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Ocoxin Oral Solution (OOS) is a nutritional supplement whose formulation includes several plant extracts and natural products with demonstrated antitumoral properties. This review summarizes the antitumoral action of the different constituents of OOS. The action of this formulation on different preclinical models as well as clinical trials is reviewed, paying special attention to the mechanism of action and quality of life improvement properties of this nutritional supplement. Molecularly, its mode of action includes a double edge role on tumor biology, that involves a slowdown in cell proliferation accompanied by cell death induction. Given the safety and good tolerability of OOS, and its potentiation of the antitumoral effect of other standard of care drugs, OOS may be used in the oncology clinic in combination with conventional therapies.

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“…Considering the role of inflammation in OA, an anti-inflammatory agent should be beneficial in slowing down the progression of this disease [50,51]. Numerous animal [52][53][54][55] and human [56] studies reported that glucosamine possesses anti-inflammatory activities in OA. Aghazadeh-Habashi et al analyzed the effects of different doses of glucosamine (20,40,80, or 160 mg/kg/day) on rats with and found that 6-day glucosamine supplementation reduced the levels of proinflammatory cytokines IL-1, IL-6, and TNF-α and prevented the increase in the serum concentrations of nitrite, a stable metabolite of NO in rats with OA [52].…”

Section: Anti-inflammatory Activities Of Glucosaminementioning

confidence: 99%

“…In a randomized, parallel-group, double-blind clinical trial, elderly patients with temporomandibular joint OA are treated with an intra-articular hyaluronic acid injection or a combination of glucosamine hydrochloride (oral 720 mg for 3 months) and intra-articular hyaluronic acid injection [56]. Both treatments effectively alleviate the symptoms of OA after 1 month of administration, but the combination of glucosamine hydrochloride is greatly beneficial to patients with OA by further reducing the IL-6, IL-1β, and TGF-β levels [56]. Notably, the role of TGF-β in OA pathogenesis is not conclusive.…”

Section: Anti-inflammatory Activities Of Glucosaminementioning

confidence: 99%

“…Protected against cartilage degradation↓ levels of inflammatory proteins in the affected knee ↓ IL-1β and TNF-α [52] Rats received glucosamine for 16 days orally at doses of 20, 40, 80, or 160 mg/kg/day ↓ IL-6 and TNF levels ↑ serum nitrite [53] Mice with OA were treated for 15 days with glucosamine at doses of 40, 80, and 160 mg/kg/day ↓ joint swelling and OA symptoms ↓ IL-β, IL-6, TNF-α, and IL-2 Rats with OA were treated with 50 or 100 mg/kg glucosamine for 2 months ↑ cytokine IL-10 and ↓TGF-1 levels [55] Wistar rats were treated for 1 month with 500 mg of glucosamine sulfate/kg with chondroitin sulfate ↓ IL-1β in serum [56] Patients with temporomandibular joint OA treated for 1 month or 1 year with 40 and 80 mg of glucosamine with hyaluronic acid (vs placebo with hyaluronic acid)…”

Section: References Study Design Findingsmentioning

confidence: 99%

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Multifaceted Protective Role of Glucosamine against Osteoarthritis: Review of Its Molecular Mechanisms

et al. 2019

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Osteoarthritis (OA) is a joint disease resulting from cartilage degeneration and causing joint pain and stiffness. Glucosamine exerts chondroprotective effects and effectively reduces OA pain and stiffness. This review aims to summarise the mechanism of glucosamine in protecting joint health and preventing OA by conducting a literature search on original articles. Current evidence has revealed that glucosamine exhibits anti-inflammatory effects by reducing the levels of pro-inflammatory factors (such as tumour necrosis factor-alpha, interleukin-1, and interleukin-6) and enhancing the synthesis of proteoglycans that retard cartilage degradation and improve joint function. Additionally, glucosamine improves cellular redox status, reduces OA-mediated oxidative damages, scavenges free radicals, upregulates antioxidant proteins and enzyme levels, inhibits the production of reactive oxygen species, and induces autophagy to delay OA pathogenesis. In conclusion, glucosamine prevents OA and maintains joint health by reducing inflammation, improving the redox status, and inducing autophagy in joints. Further studies are warranted to determine the synergistic effect of glucosamine with other anti-inflammatory and/or antioxidative agents on joint health in humans.

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Glucosamine oral administration as an adjunct to hyaluronic acid injection in treating temporomandibular joint osteoarthritis

Abstract: Both strategies alleviated symptoms in short term, but the patients treated with GS benefited more than those with placebo in long term, which may be due to the suppression of IL-1β and IL-6 and the stimulation of TGF-β.

Cited by 16 publications

References 34 publications

Effects of glucosamine supplements on painful temporomandibular joint osteoarthritis: A systematic review

Effects of glucosamine supplements on painful temporomandibular joint osteoarthritis: A systematic review

Antitumoral Properties of the Nutritional Supplement Ocoxin Oral Solution: A Comprehensive Review

Multifaceted Protective Role of Glucosamine against Osteoarthritis: Review of Its Molecular Mechanisms

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