Glucosamine Long-Term Treatment and the Progression of Knee Osteoarthritis:           Systematic Review of Randomized Controlled Trials

Poolsup, Nalinee; Suthisisang, Chutamanee; Channark, Patchareeya; Kittikulsuth, Wararat

doi:10.1345/aph.1e576

Cited by 85 publications

(52 citation statements)

References 33 publications

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“…6B), suggesting the involvement of post-ER degradation under conditions in which N-linked glycosylation is not blocked and proteasomal degradation is inhibited/minimized. Glucosamine, widely synthesized endogenously and also sold commercially for the treatment of arthritis (28,29), has recently been linked, controversially, to insulin resistance in both cultured cells and animal models (30,31). Increased plasma levels of apoB-100-containing lipoproteins are an important risk factor in the development of atherosclerosis and are commonly found in insulinresistant states and type 2 diabetes (32).…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of glucosamine-induced suppression of the hepatic assembly and secretion of apolipoprotein B-100-containing lipoproteins

Qiu

Avramoglu

Rutledge

et al. 2006

Journal of Lipid Research

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Glucosamine-induced endoplasmic reticulum (ER) stress was recently shown to specifically reduce apolipoprotein B-100 (apoB-100) secretion by enhancing the proteasomal degradation of apoB-100. Here, we examined the mechanisms linking glucosamine-induced ER stress and apoB-lipoprotein biogenesis. Trypsin sensitivity studies suggested glucosamine-induced changes in apoB-100 conformation. Endoglycosidase H studies of newly synthesized apoB-100 revealed glucosamine induced N-linked glycosylation defects resulting in reduced apoB-100 secretion. We also examined glucosamine-induced changes in VLDL assembly and secretion. A dose-dependent (1-10 mM glucosamine) reduction was observed in VLDL-apoB-100 secretion in primary hepatocytes (24.2-67.3%) and rat McA-RH7777 cells (23.2-89.5%). Glucosamine also inhibited the assembly of larger VLDL-, LDL-, and intermediate density lipoprotein-apoB-100 but did not affect smaller HDL-sized apoB-100 particles. Glucosamine treatment during the chase period (posttranslational) led to a 24% reduction in apoB-100 secretion (P , 0.01; n 5 4) and promoted post-ER apoB degradation. However, the contribution of post-ER apoB-100 degradation appeared to be quantitatively minor. Interestingly, the glucosamine-induced posttranslational reduction in apoB-100 secretion could be partially prevented by treatment with desferrioxamine or vitamin E. Together, these data suggest that cotranslational glucosamine treatment may cause defects in apoB-100 N-linked glycosylation and folding, resulting in enhanced proteasomal degradation. Posttranslationally, glucosamine may interfere with the assembly process of apoB lipoproteins, leading to post-ER degradation via nonproteasomal pathways.-Qiu, W., R.

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Section: Discussionmentioning

confidence: 99%

Mechanisms of glucosamine-induced suppression of the hepatic assembly and secretion of apolipoprotein B-100-containing lipoproteins

Qiu

Avramoglu

Rutledge

et al. 2006

Journal of Lipid Research

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“…In addition, middle ear admittance and hearing characteristics should also be mon-itored in patients who are taking drugs such as glucosamine sulfate and diacerein that may slow the degeneration of cartilage [Sarzi-Puttini et al, 2005;Poolsup et al, 2005]. Middle ear surgical intervention has been suggested for selected patients with rheumatoid arthritis [Salvinelli et al, 2004].…”

Section: Future Studiesmentioning

confidence: 99%

Middle Ear Admittance and Hearing Abnormalities in Individuals with Osteoarthritis

Rawool¹,

Harrington²

2006

Audiol Neurotol

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In osteoarthritis, the joint cartilage breaks down. Cartilage exists within the incudomalleolar and incudostapedial joints. In addition, the cartilage-covered base of the stapes footplate is bound to the cartilage-covered rim of the oval window by the annular ligament. Thus, higher prevalence of middle ear abnormalities and hearing loss can be expected in osteoarthritis due to degeneration of the cartilage and the subsequent abnormal repair response. In this study, tympanometric and audiometric data were obtained from 15 individuals diagnosed with osteoarthritis and 15 gender- and age-matched individuals without the diagnosis of arthritis. Results showed a significantly higher prevalence of middle ear abnormalities and hearing loss in ears with arthritis when compared to the control group. Interestingly, osteoarthritis and hearing loss are considered among the top chronic health concerns in older individuals although the connection between these two conditions has not been previously reported.

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“…Анализ ре-зультатов показал, что через 3 года у больных, леченных ГА сульфатом, не выявлено статистически значимого сужения суставной щели в отличие от пациентов, получающих пла-цебо (+0,06 против -0,31 мм в первом исследовании и ±0,04 мм против -0,19 мм во втором). Длительное наблюдение за этими больными позволило выявить, что от-носительный риск эндопротезирова-ния был достоверно ниже у леченных ГА сульфатом по сравнению с группой плацебо [52]. Тяжелые побочные эф-фекты на фоне приема препарата не отмечены, зафиксированы легкая тошнота, жидкий стул, головокруже-ние, которые проходят без отмены препарата.…”

Section: гбоу впо «рязанский государственный медицинский университет unclassified

Chondroprotectors in the treatment of osteoarthoris

Лыгина¹

2012

Modern Rheumatology Journal

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Glucosamine Long-Term Treatment and the Progression of Knee Osteoarthritis: Systematic Review of Randomized Controlled Trials

Abstract: The available evidence suggests that glucosamine sulfate may be effective and safe in delaying the progression and improving the symptoms of knee OA. Due to the sparse data on structural efficacy and safety, further studies are warranted.

Cited by 85 publications

References 33 publications

Mechanisms of glucosamine-induced suppression of the hepatic assembly and secretion of apolipoprotein B-100-containing lipoproteins

Mechanisms of glucosamine-induced suppression of the hepatic assembly and secretion of apolipoprotein B-100-containing lipoproteins

Middle Ear Admittance and Hearing Abnormalities in Individuals with Osteoarthritis

Chondroprotectors in the treatment of osteoarthoris

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