Glucosamine Induces Activated <scp>T</scp> Cell Apoptosis Through Reduced <scp>T</scp> Cell Receptor

Chen, Nianhong; Cheong, Kwang Ho; Kim, C.-H.; Noh, Minsoo; Lee, A.-Y.

doi:10.1111/sji.12056

Cited by 10 publications

(5 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glucosamine can be recovered in the hexosamine pathway and converted to UDP-GlcNAc. Using UDP-GlcNAc as a substrate, golgi N-glycan branching enzymes produce N-glycans, which bind to the T-cell receptor (TCR) and cytotoxic T lymphocyte antigen-4 (CTLA-4), indicating that glucosamine can regulate autoimmunity by modulating the multiple functionalities of T cells and suggesting that it exerts immunoregulation through TCR signaling, increasing the number of T cells (Chen et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

Hematologia e bioquímica sérica de frangos de corte suplementados com sulfatos de condroitina e de glucosamina na ração

et al. 2023

View full text Add to dashboard Cite

Objetivou-se avaliar a hematologia e a bioquímica sérica de frangos de corte suplementados com sulfatos de condroitina e de glucosamina na ração. Foi conduzido um experimento em delineamento inteiramente casualizado, em esquema fatorial 3 x 3 (três níveis de sulfato de condroitina: 0; 0,05 e 0,10%; e três níveis de sulfato de glucosamina: 0; 0,15 e 0,30%), cada tratamento com seis repetições de 30 aves. Foram avaliadas as variáveis de hematologia (hemácias, hemoglobina, hematócrito, proteínas plasmáticas totais [PPT], trombócitos, leucócitos, eosinófilos, monócitos, heterofilos e linfócitos) e bioquímica sérica (proteínas séricas totais [PST], albumina, globulinas, aspartato aminotransferase [AST], gama glutamiltransferase [GGT], fosfatase alcalina [FA], cálcio total, cálcio iônico, fósforo, sódio, potássio e cloretos) aos 21 e 42 dias. Os dados foram submetidos à análise de variância. Quando as médias diferiram significativamente pelo teste F, a análise ortogonal foi realizada para testar os efeitos lineares e quadráticos dos níveis dos sulfatos de condroitina e de glucosamina. Observou-se efeito linear decrescente (p = 0,0399) do sulfato de glucosamina na quantidade de monócitos aos 42 dias. Houve interação dos sulfatos para leucócitos totais (p = 0,0099) e linfócitos (p = 0,0004) aos 21 dias. Frangos suplementados com 0,10% de sulfato de condroitina mostraram um aumento linear dos leucócitos (p = 0,0287) e dos linfócitos (p = 0,0144) com a inclusão de sulfato de glucosamina. A suplementação com sulfato de condroitina aumentou linearmente (p = 0,0099) a albumina sérica e afetou de forma quadrática (p = 0,0140) as PST aos 21 dias. O sulfato de glucosamina demonstrou um efeito quadrático (p < 0,05) sobre a albumina aos 42 dias, o menor valor foi encontrado para a inclusão de 0,06%, respectivamente. O sulfato de glucosamina reduziu linearmente (p = 0,0237) os cloretos aos 21 dias e aumentou linearmente (p = 0,0012) o cálcio total aos 42 dias. Verificouse interação (p < 0,05) dos sulfatos para cálcio total aos 21 dias, cálcio iônico aos 21 e 42 dias e para fósforo, cloretos e sódio aos 42 dias. A suplementação com os sulfatos de condroitina e de glucosamina na ração de frangos de corte favoreceram o sistema imune e o metabolismo de minerais, com aumento nas concentrações séricas de cálcio, fósforo e sódio.

show abstract

Section: Resultsmentioning

confidence: 99%

Hematologia e bioquímica sérica de frangos de corte suplementados com sulfatos de condroitina e de glucosamina na ração

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Glucosamine (GlcN) is salvaged into the hexosamine pathway [ 25 ]. It suppresses T cell function by increasing the apoptosis of activated T cells [ 26 ]; urolithin treatment induces glucosamine accumulation in leukemic cells.…”

Section: Resultsmentioning

confidence: 99%

Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells

Alzahrani

Mohammed

Alghamdi

et al. 2021

IJMS

View full text Add to dashboard Cite

Leukemia is persistently a significant cause of illness and mortality worldwide. Urolithins, metabolites of ellagic acid and ellagitannins produced by gut microbiota, showed better bioactive compounds liable for the health benefits exerted by ellagic acid and ellagitannins containing pomegranate and walnuts. Here, we assessed the potential antileukemic activities of both urolithin A and urolithin B. Results showed that both urolithin A and B significantly inhibited the proliferation of leukemic cell lines Jurkat and K562, among which urolithin A showed the more prominent antiproliferative capability. Further, urolithin treatment alters leukemic cell metabolism, as evidenced by increased metabolic rate and notable changes in glutamine metabolism, one-carbon metabolism, and lipid metabolism. Next, we evidenced that both urolithins equally promoted apoptosis in leukemic cell lines. Based on these observations, we concluded that both urolithin A and B alter leukemic cell metabolome, resulting in a halt of proliferation, followed by apoptosis. The data can be used for designing new combinational therapies to eradicate leukemic cells.

show abstract

“…It was worth noting that there were a few reports on the qualitative and quantitative analysis for the composition changes in the prepared slices of Yinyanghuo compared to raw products. The content of aglycones and secondary glycosides of flavonoids in Yinyanghuo increased due to the desugarization reactions in frying (Jing et al, 2009), and it was confirmed by some studies that the content of epimedin A, B and C decreased, while icariin increased when the herb was processed (Xie et al, 2011;Chen and Luo, 2013;Zhang et al, 2018;XU et al, 2021). And the increased icariin was proved to be a hydrolysis product of 3´´´-carbonyl-2´´-β-L-quinovosyl icariin instead of epimedin A, B and C (Sun et al, 2018).…”

Section: The Composition Changes Of Pfeb and Rfeb And The Future Pros...mentioning

confidence: 88%

The pharmacological effects and safety of the raw and prepared folium of Epimedium brevicornu Maxim. on improving kidney-yang deficiency syndrome and sexual dysfunction

Wang

Zheng

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Background: Kidney-Yang deficiency syndrome (KDS) is a group of diseases related to hypothalamic-pituitary-adrenal (HPA) axis and sexual dysfunction. The folium of Epimedium brevicornu Maxim. (FEB) includes raw and prepared slices, named RFEB and PFEB, respectively. PFEB is traditionally believed to be good for tonifying kidney-Yang and improving sexual dysfunction. However, there are few studies comparing the pharmacological effects of RFEB and PFEB, and their underlying mechanisms. In this study, we aimed to compare the effects and safety of RFEB and PFEB on the HPA axis and sexual function. Additionally, the mechanisms of their roles in relation to the neuroendocrine-immune (NEI) network in the KDS model mice were explored.Methods: Male adult C57BL/6 mice were treated with corticosterone to establish a KDS mouse model, and RFEB and PFEB were administered intragastrically. Corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH), cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP), testosterone levels and oxidative damage indexes were measured. The mRNA and protein levels of CRH and ACTH in hypothalamus and pituitary, endothelial nitric oxide synthase (eNOS) and phosphodiesterase 5 (PDE5) in corpus cavernosum were examined. TNFα, IL-6, NF-κB, eNOS and PDE5 were investigated in mouse corpus cavernosum.Results: Our results showed that PFEB was more effective than RFEB in increasing corticosterone-suppressed ACTH levels, enhancing CRH levels and cAMP/cGMP ratio, and reducing oxidative damage. In vivo, PFEB significantly increased eNOS and inhibited PDE5 expression in corpus cavernosum. PFEB showed stronger protective effect on normal spleen lymphocytes from apoptosis both in vitro and in vivo. Additionally, it noticeably inhibited the levels of inflammatory cytokines in corpus cavernosum. Both RFEB and PFEB were safe and did not cause any clinical signs of toxicity in mice at the dosage of 20 times dosages of that in the Chinese Pharmacopeia.Conclusion: We demonstrated that PFEB was better than RFEB at tonifying the kidney-Yang by comparing their effects on improving the NEI network, which includes the HPA axis, immune system and corpus cavernosum. This study revealed that PFEB could significantly improve the sexual function of KDS mice by regulating the HPA axis and activating the immune system through the NEI network.

show abstract

Glucosamine Induces Activated T Cell Apoptosis Through Reduced T Cell Receptor

Cited by 10 publications

References 36 publications

Hematologia e bioquímica sérica de frangos de corte suplementados com sulfatos de condroitina e de glucosamina na ração

Hematologia e bioquímica sérica de frangos de corte suplementados com sulfatos de condroitina e de glucosamina na ração

Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells

The pharmacological effects and safety of the raw and prepared folium of Epimedium brevicornu Maxim. on improving kidney-yang deficiency syndrome and sexual dysfunction

Contact Info

Product

Resources

About