Glucosamine and chondroitin sulfates in the treatment of osteoarthritis: a survey

Reyes, Gerlie C de los; Koda, Robert T.; Lien, Eric J.

doi:10.1007/978-3-0348-8385-6_3

Cited by 28 publications

(20 citation statements)

References 14 publications

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“…There are also several deepened reviews that well described the rationale for use and efficacy of chondroitin sulphate in OA [78,[89][90][91][92][93][94][95][96].…”

Section: Human Studiesmentioning

confidence: 99%

Chondroitin Sulphate: Antioxidant Properties and Beneficial Effects

Campo¹,

Avenoso²,

Campo³

et al. 2006

MRMC

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Most biological molecules exhibit more than one function. In particular, many molecules have the ability to directly/indirectly scavenge free radicals and thus act in living organisms as antioxidant. During oxidative stress, the increase of these molecules levels seems to be a biological response that in synergism with the other antioxidant defence systems may protect cells from oxidation. Among these structures, chondroitin sulphate is a biomolecule which has increasingly focused the interest of many research groups due to its antioxidant activity. This review briefly summarises the action of chondroitin sulphate in reducing molecular damage caused by free radicals and associated oxygen reactants.

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“…There are also several deepened reviews that well described the rationale for use and efficacy of chondroitin sulphate in OA [78,[89][90][91][92][93][94][95][96].…”

Section: Human Studiesmentioning

confidence: 99%

Chondroitin Sulphate: Antioxidant Properties and Beneficial Effects

Campo¹,

Avenoso²,

Campo³

et al. 2006

MRMC

View full text Add to dashboard Cite

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“…Glucosamine is involved in cartilage formation by acting as the precursor of the disaccharide unit in glycosaminoglycans (GAGs) (Baker and Ferguson, 2005;De los Reyes et al, 2000;Scott et al, 2005). Chondroitin sulfate is a GAG that is a component of the aggrecan structure that makes up articular cartilage (Freeman, 1979).…”

Section: Introductionmentioning

confidence: 99%

Immunological Activity of Chondroitin Sulfate

Toida

Sakai

Akiyama

et al. 2006

Chondroitin Sulfate: Structure, Role and Pharmacological Activity

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“…Glucosamine is an amino sugar that acts as a precursor in the biosynthesis of GAGs and proteoglycan aggregates (de los Reyes et al, 2000). The biologic mechanisms underlying the apparent benefits of glucosamine remain obscure.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Glucosamine and Snail Mucin on the Progression of Experimental Knee Osteoarthritis in Dogs

et al. 2013

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SUMMARY:This study evaluated the effect of oral glucosamine and intramuscular injection (IM) of snail mucin on the progression of experimental osteoarthritis (OA) in dogs. Twenty adult mongrels with mean body weight (12.4±1.8 kg) were used. Experimental OA was induced surgically using the groove model. The dogs were randomly divided into three groups following radiographic evidence of OA. Group one (control) comprised of ten dogs treated with normal saline twice weekly for four weeks following OA. Group two comprised of five dogs treated with 10mg/kg of oral glucosamine daily for four weeks. Group three comprised of five dogs treated with 5mg/kg intramuscular injection of 5% solution of snail mucin twice weekly for four weeks. Blood was obtained from the cephalic vein before surgical arthrotomy, after surgical arthrotomy, immediately after radiographic confirmation of OA (Week 0) and at two weeks interval up to 4 weeks of treatment. Efficacy of the drugs was assessed by changes in plasma IL-6 and MMP-3, while safety was determined using the changes in packed cell volume (PCV), total white blood cell counts (WBC) and observable adverse reactions associated with the administration of the drugs. In this study, the PCV and WBC did not differ significantly (P> 0.05) from the control group. Plasma IL-6 and MMP-3 were significantly (P< 0.05) lower both in glucosamine-treated and snail mucin-treated dogs up to week 4 of treatment when compared with the control group. However, there were no significant (P > 0.05) differences in IL-6 and MMP-3 between the two treatment groups. In addition, painful swelling at the site of injection was observed in dogs treated with snail mucin, while no adverse reaction was observed in dogs treated with oral glucosamine. It was therefore concluded that both oral glucosamine and IM injection of snail mucin comparably modified the progression of OA. However, owing to the adverse reaction noted with IM injection of snail mucin, further study is required to determine the most appropriate route of administration.

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Glucosamine and chondroitin sulfates in the treatment of osteoarthritis: a survey

Cited by 28 publications

References 14 publications

Chondroitin Sulphate: Antioxidant Properties and Beneficial Effects

Chondroitin Sulphate: Antioxidant Properties and Beneficial Effects

Immunological Activity of Chondroitin Sulfate

Evaluation of Glucosamine and Snail Mucin on the Progression of Experimental Knee Osteoarthritis in Dogs

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