Glucosamine Administration in Athletes: Effects on Recovery of Acute Knee Injury

Ostojić, Sergej M.; Arsić, Miodrag; Prodanović, Slobodan; Vukovic, J.; Zlatanović, Milorad

doi:10.1080/15438620701405248

Cited by 24 publications

(16 citation statements)

References 25 publications

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“…It is the most prevalent musculoskeletal disorder diagnosed in the United States which affects nearly 15% of Americans and costs an estimated $80 billion dollars annually [41]. Athletes with prior knee injuries and individuals who maintain an active lifestyle as they age are also at risk to experience knee pain or degenerative joint issues [5,27,28]. Although the etiology of OA involves multiple factors, obesity has been identified as a primary risk factor involved in the development of the disease [9].…”

Section: Discussionmentioning

confidence: 99%

Effects of diet type and supplementation of glucosamine, chondroitin, and MSM on body composition, functional status, and markers of health in women with knee osteoarthritis initiating a resistance-based exercise and weight loss program

Magrans-Courtney

Wilborn

Rasmussen

et al. 2011

Journal of the International Society of Sports Nutrition

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BackgroundThe purpose of this study was to determine whether sedentary obese women with knee OA initiating an exercise and weight loss program may experience more beneficial changes in body composition, functional capacity, and/or markers of health following a higher protein diet compared to a higher carbohydrate diet with or without GCM supplementation.MethodsThirty sedentary women (54 ± 9 yrs, 163 ± 6 cm, 88.6 ± 13 kg, 46.1 ± 3% fat, 33.3 ± 5 kg/m2) with clinically diagnosed knee OA participated in a 14-week exercise and weight loss program. Participants followed an isoenergenic low fat higher carbohydrate (HC) or higher protein (HP) diet while participating in a supervised 30-minute circuit resistance-training program three times per week for 14-weeks. In a randomized and double blind manner, participants ingested supplements containing 1,500 mg/d of glucosamine (as d-glucosamine HCL), 1,200 mg/d of chondroitin sulfate (from chondroitin sulfate sodium), and 900 mg/d of methylsulfonylmethane or a placebo. At 0, 10, and 14-weeks, participants completed a battery of assessments. Data were analyzed by MANOVA with repeated measures.ResultsParticipants in both groups experienced significant reductions in body mass (-2.4 ± 3%), fat mass (-6.0 ± 6%), and body fat (-3.5 ± 4%) with no significant changes in fat free mass or resting energy expenditure. Perception of knee pain (-49 ± 39%) and knee stiffness (-42 ± 37%) was decreased while maximal strength (12%), muscular endurance (20%), balance indices (7% to 20%), lipid levels (-8% to -12%), homeostasis model assessment for estimating insulin resistance (-17%), leptin (-30%), and measures of physical functioning (59%), vitality (120%), and social function (66%) were improved in both groups with no differences among groups. Functional aerobic capacity was increased to a greater degree for those in the HP and GCM groups while there were some trends suggesting that supplementation affected perceptions of knee pain (p < 0.08).ConclusionsCircuit style resistance-training and weight loss improved functional capacity in women with knee OA. The type of diet and dietary supplementation of GCM provided marginal additive benefits.Trial RegistrationClinicalTrials.gov: NCT01271218

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Section: Discussionmentioning

confidence: 99%

Effects of diet type and supplementation of glucosamine, chondroitin, and MSM on body composition, functional status, and markers of health in women with knee osteoarthritis initiating a resistance-based exercise and weight loss program

Magrans-Courtney

Wilborn

Rasmussen

et al. 2011

Journal of the International Society of Sports Nutrition

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“…The applicant provided two human studies as pertinent to the claim. The first study was a randomized, double-blind, placebo-controlled trial [50] including 121 male patients who had a recent history of acute knee sport injury. They received either 1.5 g GlcN (n=62) per day or placebo (cellulose; n = 59) for 28 days.…”

Section: Discussionmentioning

confidence: 99%

Physiological effects of oral glucosamine on joint health: current status and consensus on future research priorities

et al. 2013

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The aim of this paper was to provide an overview of the current knowledge and understanding of the potential beneficial physiological effects of glucosamine (GlcN) on joint health. The objective was to reach a consensus on four critical questions and to provide recommendations for future research priorities. To this end, nine scientists from Europe and the United States were selected according to their expertise in this particular field and were invited to participate in the Hohenheim conference held in August 2011. Each expert was asked to address a question that had previously been posed by the chairman of the conference. Based on a systematic review of the literature and the collection of recent data, the experts documented the effects of GlcN on cartilage ageing, metabolic/kinetic and maintenance of joint health as well as reduction of risk of OA development. After extensive debate and discussion the expert panel addressed each question and a general consensus statement was developed, agreeing on the current state-of-the-art and future areas for basic and clinical studies. This paper summarizes the available evidence for beneficial effects of GlcN on joint health and proposes new insight into the design of future clinical trials aimed at identifying beneficial physiological effect of GlcN on joint tissues.

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“…In a randomised, double-blind, placebo-controlled trial (Ostojic et al, 2007), 121 male patients who had a recent history of acute sports injury of the knee, and had clinical findings consistent with trauma (acute minor knee injuries, less than grade II based on clinical findings according to the Outerbridge classification), received 1.5 g glucosamine (n=62) per day or placebo (cellulose; n=59) for 28 days. The search was limited to human trials which were published in English.…”

Section: Scientific Substantiation Of the Claimed Effectmentioning

confidence: 99%

Scientific Opinion on the substantiation of a health claim related to glucosamine and maintenance of joints pursuant to Article 13(5) of Regulation (EC) No 1924/2006

Products¹

2011

EFSA Journal

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Following an application from Béres Pharmaceuticals Ltd., submitted pursuant to Article 13(5) of Regulation (EC) No 1924 via the Competent Authority of Hungary, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim based on newly developed scientific evidence related to glucosamine and maintenance of joints. The food constituent that is the subject of the health claim is glucosamine, which is sufficiently characterised. The claimed effect is "contributes to the protection of joint cartilage exposed to excessive motion or loading and helps to improve the range of motion in joints". The target population proposed by the applicant is healthy individuals exposed to excessive load on the joints. Maintenance of joints is a beneficial physiological effect. The applicant provided two human studies as pertinent to the claim. One study was carried out in patients with acute injury of the knee. The evidence provided does not establish that patients with acute knee injury are representative of the target population with regard to the status of joint tissues, or that results obtained in studies on subjects with acute knee injury can be extrapolated to the proposed target population. The second study was an intervention with endpoints on putative biomarkers of collagen type II metabolism. The study was not adequately controlled and the evidence provided does not establish that changes in the proposed biomarkers over periods of three months can predict net changes in collagen type II in joint cartilage. The Panel concludes that a cause and effect relationship has not been established between the consumption of glucosamine and maintenance of joints.

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Glucosamine Administration in Athletes: Effects on Recovery of Acute Knee Injury

Cited by 24 publications

References 25 publications

Effects of diet type and supplementation of glucosamine, chondroitin, and MSM on body composition, functional status, and markers of health in women with knee osteoarthritis initiating a resistance-based exercise and weight loss program

Effects of diet type and supplementation of glucosamine, chondroitin, and MSM on body composition, functional status, and markers of health in women with knee osteoarthritis initiating a resistance-based exercise and weight loss program

Physiological effects of oral glucosamine on joint health: current status and consensus on future research priorities

Scientific Opinion on the substantiation of a health claim related to glucosamine and maintenance of joints pursuant to Article 13(5) of Regulation (EC) No 1924/2006

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