Glucosamine-6-phosphate synthase—the multi-facets enzyme

Activated Sugar Precursors: Biosynthetic Pathways and Biological Roles of an Important Class of Intermediate Metabolites in Bacteria

“…In bacteria, uridine 5'-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc) is the activated form of N-acetylglucosamine, an essential precursor for the biosynthesis of various important carbohydrate-containing structures, as is the case of the cell wall peptidoglycan, LPS and teichoic acids (Milewski, 2002). Enzymes leading to the synthesis of UDP-GlcNAc are essential for the cell wall formation, being regarded as attractive targets for the development of antibacterial compounds (Kotnik et al, 2007).…”

“…Enzymes leading to the synthesis of UDP-GlcNAc are essential for the cell wall formation, being regarded as attractive targets for the development of antibacterial compounds (Kotnik et al, 2007). Glucosamine-6-phosphate synthase (GlcN-6-P synthase or GlmS in bacteria, EC 2.6.1.16) catalyses the first step in the pathway that leads to the formation of UDP-GlcNAc (Milewski, 2002) (Fig. 11).…”

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“…2 Role of GlcN6P synthase in bacteria, eukaryotic organisms, glucose metabolism related to diabetes, cancer, inflammation and ulcer has been reviewed elsewhere. 3 On the other hand, chalcone nucleus having prominent activities against microbes is known [4][5][6] . A recent pharmaco-phore based studies by M.A.…”

Structural Basis for Morpheein-type Allosteric Regulation of Escherichia coli Glucosamine-6-phosphate Synthase

“…Because the end product of the pathway, UDP-N-acetylglucosamine (UDP-GlcNAc), is an important building block of bacterial and fungal cell walls, GlmS is a potential target for antibacterial and antifungal drugs (2,3). Escherichia coli GlmS is composed of two structurally and functionally distinct globular domains connected by a linker (supplemental Fig.…”