Gluconeogenic enzymes in the human placenta

Matalon, Reuben; Michals, K.

doi:10.1007/bf01805607

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…In this regard, our results do not agree with a placental production of lactate in vitro [29,30] which, however, may be due to a 'wash-out' effect during perfusion [30,31]. The placental lactate metabolism could be related to that of alanine (via the pyruvate) in so far as the placenta produces alanine in normal conditions [32,33] and an alanine aminotransferase activity was found in the cytosolic fraction of human placenta [34]. Further studies on this hypothesis should be done.…”

Section: Discussioncontrasting

confidence: 51%

Lactate Movements in the Term Human Placenta in situ

Piquard

Schaefer

Dellenbach³

et al. 1990

Neonatology

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Movements of lactate through the human placenta in situ were derived from maternal and fetal blood sampling performed under conditions that approximate as closely as possible the normal fetal metabolic state. It is reported that, at the end of pregnancy, the human fetus produces lactate which is transferred to the placenta. The actuality of this lactate transfer coupled with proton transfer is discussed taking into account the results of multiple linear regression analysis determined between the umbilical arterio-venous lactate differences and fetal and maternal lactate and proton concentrations. It is finally assumed that this lactate is partly metabolized in the placenta, the remaining part being transferred from the placenta to the mother.

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Section: Discussioncontrasting

confidence: 51%

Lactate Movements in the Term Human Placenta in situ

Piquard

Schaefer

Dellenbach³

et al. 1990

Neonatology

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show abstract

“…Although glycogen during pregnancy has been reported (Ville, 1953), the placenta does not synthesize glycogen efficiently (Barash et al, 1991). There are data showing the presence of gluconeogenic enzymes (Matalon & Michals, 1984), and Prendergast et al demonstrate that the placenta synthesizes glucose, and evidence of the presence of glucose-6-phosphatase has been published (Matsubara et al, 1999;Prendergast et al, 1999); however, it is unknown whether the glucose synthesis might have any physiologic relevance.…”

Section: Transport Of Carbohydrates Lipids and Amino Acidsmentioning

confidence: 99%