Glucometabolic changes influence hospitalization and outcome in patients with COVID-19: An observational cohort study

Clausen, Clara Lundetoft; Leo-Hansen, Christian; Faurholt‐Jepsen, Daniel; Krogh-Madsen, Rikke; Ritz, Christian; Kirk, Ole; Jørgensen, Henrik L.; Benfield, Thomas; Almdal, Thomas; Snorgaard, Ole

doi:10.1016/j.diabres.2022.109880

Cited by 3 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In patients with diabetes mellitus who had cardiovascular disease or COVID‐19, factors including acute‐to‐chronic (A/C) glycemic ratio, stress hyperglycemia ratio or glycemic gap have been found to be strongly associated with the outcome rather than blood glucose or glycated hemoglobin (HbA1c) levels on admission 6 , 7 , 8 , 9 ; this suggests that the magnitude of acute blood glucose elevation from chronic levels could be harmful. However, these indicators have not been previously confirmed in patients with undiagnosed diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

Association of acute‐to‐chronic glycemic ratio and outcomes in patients with COVID‐19 and undiagnosed diabetes mellitus: A retrospective nationwide cohort study

Uchihara

Sugiyama

Bouchi

et al. 2023

J of Diabetes Invest

View full text Add to dashboard Cite

Aims/Introduction To assess the association of undiagnosed diabetes mellitus and its acute‐to‐chronic glycemic ratio with clinical outcome in patients hospitalized with coronavirus disease 2019 (COVID‐19) using a large‐scale nationwide registry in Japan. Materials and Methods Overall, 4,747 patients were included between July 2021 and January 2022. We evaluated blood glucose and glycated hemoglobin levels at admission, and calculated the acute‐to‐chronic glycemic ratio for each non‐diabetes mellitus, undiagnosed diabetes mellitus and pre‐existing diabetes mellitus group. The primary composite outcome comprised in‐hospital mortality, invasive mechanical ventilation, extracorporeal membrane oxygenation support, intensive care unit admission and transfer to a more advanced medical facility. Results Compared with the non‐diabetes mellitus group, the undiagnosed diabetes mellitus group was significantly associated with a worse COVID‐19 outcome (odds ratio 2.18, 95% confidence interval 1.50–3.18). In patients with undiagnosed diabetes mellitus, the 3rd tertile of the acute‐to‐chronic glycemic ratio was linked with a worse COVID‐19 outcome compared with the 1st tertile (odds ratio 3.33, 95% confidence interval 1.43–7.77), whereas glycated hemoglobin levels were not; among patients with pre‐existing diabetes mellitus, glycated hemoglobin levels were linked with a worse outcome. Conclusions Among patients with undiagnosed diabetes mellitus with COVID‐19, the magnitude of elevation of blood glucose from chronic to acute levels is associated with worse outcomes.

show abstract