Glucokinase as a Glucose Sensor in Hypothalamus - Regulation by Orexigenic and Anorexigenic Peptides

Sanz, Carmen; Roncero, Isabel; Álvarez, Elvira; Hurtado, Verónica; Blázquez, Enrique

doi:10.5772/20826

Cited by 2 publications

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References 120 publications

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“…The discovery of the presence of functional sweet taste receptors in the brain has thrown more light to our understanding of metabolic functioning involving glucose regulation. Metabolic or energy sensors in the neuroastroglial system include glucokinase, GLUT2 [ 84 , 85 ], AMPK (AMP activated protein kinase), CREB (cAMP related element binding protein), mTOR (mammalian target of rapamycin), sirtuins, and PASK (or PASKIN and PSK, a kinase protein) [ 64 , 86 – 90 ]. The study by Ren et al [ 24 ] has shown that the sweet taste receptor heterodimer T1R2+T1R3 might be responsible for mediating the energy sensing activity of previously identified metabolic sensors.…”

Section: The Sweet Taste Receptor Heterodimer T1r2+t1r3 As a Modmentioning

confidence: 99%

Sweet Taste Receptor Signaling Network: Possible Implication for Cognitive Functioning

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Mastorakis

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2015

Neurology Research International

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Sweet taste receptors are transmembrane protein network specialized in the transmission of information from special “sweet” molecules into the intracellular domain. These receptors can sense the taste of a range of molecules and transmit the information downstream to several acceptors, modulate cell specific functions and metabolism, and mediate cell-to-cell coupling through paracrine mechanism. Recent reports indicate that sweet taste receptors are widely distributed in the body and serves specific function relative to their localization. Due to their pleiotropic signaling properties and multisubstrate ligand affinity, sweet taste receptors are able to cooperatively bind multiple substances and mediate signaling by other receptors. Based on increasing evidence about the role of these receptors in the initiation and control of absorption and metabolism, and the pivotal role of metabolic (glucose) regulation in the central nervous system functioning, we propose a possible implication of sweet taste receptor signaling in modulating cognitive functioning.

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