Glucocorticoids up-regulate the expression of glial fibrillary acidic protein in the rat suprachiasmatic nucleus

Maurel, Daniel; Sage, Dominique; Mekaouche, Mourad; Bosler, Olivier

doi:10.1002/(sici)1098-1136(20000201)29:3<212::aid-glia3>3.0.co;2-6

Cited by 47 publications

(31 citation statements)

References 89 publications

(91 reference statements)

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“…For instance, a low protein diet (9 g casein/100 g diet) administered to rats from 14 days prior to mating and then during gestation was able to elevate brain and liver activities of specific glucocorticoid-inducible marker enzymes, in comparison to the situation in controls (Langley-Evans et al, 1996). A recent report supports the idea that glucocorticoids up-regulate the expression of GFAP in the SCN (Maurel et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

GFAP Expression in Astrocytes of Suprachiasmatic Nucleus and Medial Preoptic Area are Differentially Affected by Malnutrition during Rat Brain Development

Mendonça

Vilela²,

Bittencourt³

et al. 2004

Nutritional Neuroscience

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The aim of the present study was investigate, in young rats, the effects of malnutrition on astrocyte distribution of two hypothalamic regions, the circadian pacemaker suprachiasmatic nucleus (SCN) and the medial preoptic area (MPA). Control rats were born from mothers fed on commercial diet since gestation and malnourished rats from mothers fed on multideficient diet, from the beginning of gestation (GLA group) or from the onset of lactation (LA group). After weaning, pups received ad libitum the same diet as their mothers, and were maintained under a 12/12 h light/dark cycle. The animals were analyzed either at 30-33, or 60-63 days of life. Brain coronal sections (50 microm) were processed to visualize glial fibrillary acidic protein (GFAP) immunoreactivity. Compared to control rats, both malnourished groups of 30 and 60 days exhibited a reduced number of GFAP-immunoreactive astrocytes in the SCN. The total GFAP-immunoreactive area in the SCN of the GLA group differed from the control group at both age ranges analyzed. The GFAP expression as measured by the relative optical density (ROD) exhibited a 50-60% reduction in the MPA in both malnourished groups, compared to controls. The results suggest that malnutrition early in life leads to alterations in gliogenesis or glial cell proliferation in both nuclei, being these alterations greater in the MPA. Compensatory plasticity mechanisms in the GFAP-expression seem to be developed in the astrocyte differentiation process in the SCN, especially when the malnutrition is installed from the lactation.

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Section: Discussionmentioning

confidence: 99%

GFAP Expression in Astrocytes of Suprachiasmatic Nucleus and Medial Preoptic Area are Differentially Affected by Malnutrition during Rat Brain Development

Mendonça

Vilela²,

Bittencourt³

et al. 2004

Nutritional Neuroscience

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“…High glucocorticoid levels may affect the synthesis of 5-hydroxytryptamine (i.e., serotonin). 25 This neurotransmitter is associated with the adequate performance of cognitive functions such as learning, memory, and attentional processes. 26 …”

Section: Discussionmentioning

confidence: 99%

Prednisone Induces Cognitive Dysfunction, Neuronal Degeneration, and Reactive Gliosis in Rats

Ramos-Remus

González-Castañeda

González-Pérez

et al. 2002

Journal of Investigative Medicine

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“…Whereas GFAP levels in the hippocampus were increased as a consequence of an adrenalectomy, application of corticosterone led to a decrease in GFAP [41]. In contrast to these findings, Maurel et al found upregulation of GFAP in the suprachiasmatic nucleus and in parts of the paraventricular nucleus, whereas no changes were observed in the hippocampus [38]. Increased expression of GFAP was also found in vitro after the application of cortisol [39].…”

Section: Discussionmentioning

confidence: 89%

Cortisol promotes survival and regeneration of axotomised retinal ganglion cells and enhances effects of aurintricarboxylic acid

Heiduschka

Thanos

2006

Graefe's Arch Clin Exp Ophthalmo

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Glucocorticoids up-regulate the expression of glial fibrillary acidic protein in the rat suprachiasmatic nucleus

Cited by 47 publications

References 89 publications

GFAP Expression in Astrocytes of Suprachiasmatic Nucleus and Medial Preoptic Area are Differentially Affected by Malnutrition during Rat Brain Development

GFAP Expression in Astrocytes of Suprachiasmatic Nucleus and Medial Preoptic Area are Differentially Affected by Malnutrition during Rat Brain Development

Prednisone Induces Cognitive Dysfunction, Neuronal Degeneration, and Reactive Gliosis in Rats

Cortisol promotes survival and regeneration of axotomised retinal ganglion cells and enhances effects of aurintricarboxylic acid

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