Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation
Tamara Diamanti,
Laura Trobiani,
Lorenza Mautone
et al.
Abstract:Neuroligins are synaptic cell adhesion proteins with a role in synaptic function, implicated in neurodevelopmental disorders. The autism spectrum disorder‐associated substitution Arg451Cys (R451C) in NLGN3 promotes a partial misfolding of the extracellular domain of the protein leading to retention in the endoplasmic reticulum (ER) and the induction of the unfolded protein response (UPR). The reduced trafficking of R451C NLGN3 to the cell surface leads to altered synaptic function and social behavior. A screen… Show more
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