Glucocorticoids negatively relate to body mass on the short-term in a free-ranging ungulate

Lalande, Lucas D.; Gilot‐Fromont, Emmanuelle; Carbillet, Jeffrey; Débias, François; Duhayer, Jeanne; Gaillard, Jean‐Michel; Lemaître, Jean‐François; Palme, Rupert; Pardonnet, Sylvia; Pellerin, Maryline; Rey, Benjamin; Vuarin, Pauline

doi:10.1101/2022.09.15.508076

Cited by 3 publications

(4 citation statements)

References 120 publications

(254 reference statements)

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“…A recent study on the same two roe deer populations has shown that baseline GC levels were negatively associated with individual body mass, but GCs measured during the first year of life showed no delayed relationship with adult body mass (Lalande et al 2023).…”

Section: Discussionmentioning

confidence: 92%

“…at about 8 months of age) corrected for the Julian date of capture (Gaillard et al 1996). This metric of environmental quality allows accounting for the influence of environmental conditions early in life on roe deer performance, which predominate over current environmental conditions in roe deer (Pettorelli et al 2002), and captures more reliably the effect of 'cohort quality' (sensu Gaillard et al 2003 and see Lalande et al 2023 andCambreling et al 2023 for case studies for GCs-body mass relationships and senescence of antler size, respectively). Such an integrative metric of natal environmental conditions encompasses variations in early environmental conditions (e.g.…”

Section: Study Populationsmentioning

confidence: 99%

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Early-life glucocorticoids accelerate lymphocyte count senescence in roe deer

Lalande,

Bourgoin,

Carbillet

et al. 2024

Preprint

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Immunosenescence corresponds to the progressive decline of immune functions with increasing age. Although it is critical to understand what modulates such a decline, the ecological and physiological drivers of immunosenescence remain poorly understood in the wild. Among them, the level of glucocorticoids (GCs) during early life are good candidates to modulate immunosenescence patterns because these hormones can have long-term consequences on individual physiology. Indeed, GCs act as regulators of energy allocation to ensure allostasis, are part of the stress response triggered by unpredictable events and have immunosuppressive effects when chronically elevated. We used longitudinal data collected over two decades in two populations of roe deer (Capreolus capreolus) to test whether higher baseline GC levels measured within the first year of life were associated with a more pronounced immunosenescence and parasite susceptibility. We first assessed immunosenescence trajectories in these populations facing contrasting environmental conditions. We found no evidence that juvenile GC levels can modulate these trajectories except for lymphocytes for which depletion was accelerated late in life when FGMs were elevated early in life. Although the exact mechanism remains unknown, this result suggests a role of GCs in promoting T cells apoptosis and thymic involution. Adrenal GCs can also promote the production of thymic GCs, specifically amplifying the effects of GCs on lymphocyte compared to other immune traits. In addition, elevated GC levels in juveniles were associated with a higher abundance of lung parasites during adulthood for individuals born during bad years, suggesting short-term negative effects of GCs on juvenile immunity, having in turn long-lasting consequences on adult parasite load, depending on juvenile environmental conditions. These findings offer promising research directions in assessing the carry-over consequences of GCs on life-history traits in the wild.

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Section: Discussionmentioning

confidence: 92%

Section: Study Populationsmentioning

confidence: 99%

Early-life glucocorticoids accelerate lymphocyte count senescence in roe deer

Lalande,

Bourgoin,

Carbillet

et al. 2024

Preprint

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“…Additionally, the study of Anderwald et al ( 2021 ) was partly biased toward female chamois (roughly 76% of the study population), while our study was performed in males: it cannot be excluded that the contrasting results were caused by sex‐specific stress responses, for example, related to sex‐specific hormones that impact glucocorticoid secretion and excretion, possibly by different receptors that lead to distinct physiological responses (cf. Lalande et al, 2022 ).…”

Section: Discussionmentioning

confidence: 98%

Season‐dependent impact of forage quality on stress in alpine chamois

Corlatti

Palme

Valencak

et al. 2023

Ecology and Evolution

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Chronically heightened stress levels in wildlife species may have detrimental effects on individual life history traits, for example, through the increased likelihood of disease, parasitic infections, and overall reduced fitness. Understanding the drivers of stress may thus have great potential for informing wildlife conservation. Although the role of climate and individual status is well studied in stress ecology, the impact of related stressors such as dietary quality is of increasing interest to wildlife research and conservation. In this study, fecal cortisol metabolites (FCMs) in Alpine chamois Rupicapra r. rupicapra used as bioindicators of stress, and their relationship with forage quality—measured as the percentage of fecal crude protein (CP)—were investigated. Data collection took place in 2011 and 2012 in the Gran Paradiso National Park (Western Italian Alps), on 22 individually marked adult males. The relationship between FCMs and CPs was analyzed through linear models and separated between winter and summer months, accounting for the effect of potentially confounding exogenous and endogenous variables. After AICc‐based model selection, we found that forage quality was negatively related to FCM levels in Alpine chamois during the summer months, meaning that higher quality forage was associated with the decreased expression of stress hormones. However, during the winter months, we did not find a significant relationship, potentially as a result of forage quality being ubiquitously poor. Although the mechanisms through which dietary variations impact FCM concentrations in wildlife populations are largely unknown, the occurrence of significant relationships between forage quality and stress levels supports potentially important implications for the long‐term effect of climatic changes on the fitness of wildlife populations.

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“…Data are available from the Dryad Digital Repository: https:// doi.org/10.5061/dryad.pnvx0k6sk (Lalande et al 2023).…”

Section: Author Contributionsmentioning

confidence: 99%

Glucocorticoids negatively relate to body mass on the short‐term in a free‐ranging ungulate

Lalande

Gilot‐Fromont

Carbillet

et al. 2023

Oikos

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Environmental fluctuations force animals to adjust glucocorticoids (GCs) secretion and release to current conditions. GCs are a widely used proxy of an individual stress level. While short‐term elevation in GCs is arguably beneficial for fitness components, previous studies have documented that the relationship between long‐term baseline GCs elevation and fitness components can vary according to ecological and individual factors and according to the life‐history of the species studied. Using longitudinal data on roe deer Capreolus capreolus from two populations facing markedly different environmental contexts, we tested whether baseline GC levels negatively correlate with body mass – a trait positively associated with demographic individual performance – on the short‐ to long‐term. In support, higher baseline GC concentrations were associated to lighter body mass, both measured during the same capture event, in adults of both populations. Overall, we showed that despite the marked environmental and demographic differences between populations and despite the between‐sex differences in life history (i.e. reproductive tactics), the relationship between body mass and GCs is consistent across environmental contexts, but might differ according to the life history stage of an individual. This work opens promising perspectives to further explore the relationship between GC and fitness‐related traits according to life history stages in free‐ranging mammals across seasonal and environmental contexts. The timing and context‐dependence of GC levels highlight the complexity of studying stress responses in the wild.

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Glucocorticoids negatively relate to body mass on the short-term in a free-ranging ungulate

Cited by 3 publications

References 120 publications

Early-life glucocorticoids accelerate lymphocyte count senescence in roe deer

Early-life glucocorticoids accelerate lymphocyte count senescence in roe deer

Season‐dependent impact of forage quality on stress in alpine chamois

Glucocorticoids negatively relate to body mass on the short‐term in a free‐ranging ungulate

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