Glucocorticoids for croup

Russell, Kelly; Wiebe, Natasha; Saenz, Antonio; Segura, Mónica Ausejo; Johnson, David W.; Hartling, Lisa; Klassen, Terry P

doi:10.1002/14651858.cd001955.pub2

Cited by 97 publications

(89 citation statements)

References 89 publications

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“…11 Short courses of oral steroids have been shown to be safe, in the absence of contraindications. 12 A systematic review reported that participants with a sore throat, taking a single dose of steroid, were 3 times more likely to experience complete resolution within 24 hours.…”

Section: Resultsmentioning

confidence: 99%

Effect of Oral Dexamethasone Without Immediate Antibiotics vs Placebo on Acute Sore Throat in Adults

Hayward

Moore

Jawad

et al. 2017

JAMA

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IMPORTANCE Acute sore throat poses a significant burden on primary care and is a source of inappropriate antibiotic prescribing. Corticosteroids could be an alternative symptomatic treatment.OBJECTIVE To assess the clinical effectiveness of oral corticosteroids for acute sore throat in the absence of antibiotics. Double-blind, placebo-controlled randomized trial (April 2013-February 2015 28-day follow-up completed April 2015) conducted in 42 family practices in South and West England, enrolled 576 adults recruited on the day of presentation to primary care with acute sore throat not requiring immediate antibiotic therapy. DESIGN, SETTING, AND PARTICIPANTSINTERVENTIONS Singleoraldoseof10mgofdexamethasone(n = 293)oridenticalplacebo(n = 283). MAIN OUTCOMES AND MEASURESPrimary: proportion of participants experiencing complete resolution of symptoms at 24 hours. Secondary: complete resolution at 48 hours, duration of moderately bad symptoms (based on a Likert scale, 0, normal; 6, as bad as it could be), visual analog symptom scales (0-100 mm; 0, no symptom to 100, worst imaginable), health care attendance, days missed from work or education, consumption of delayed antibiotics or other medications, adverse events. RESULTSOf 565 eligible randomized participants (median age, 34 years [interquartile range, 26.0-45.5 years]; 75.2% women; 100% completed the intervention), 288 received dexamethasone and 277, placebo. At 24 hours, participants receiving dexamethasone were not more likely than those receiving placebo to have complete symptom resolution. Results were similar among those who were not offered an antibiotic prescription and those who were offered a delayed antibiotic prescription. At 48 hours, more participants receiving dexamethasone than placebo had complete symptom resolution. This difference also was observed in patients not offered delayed antibiotics. There were no significant differences in any other secondary outcomes. Resolution of Symptoms at 24 h (Primary Outcome)

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Section: Resultsmentioning

confidence: 99%

Effect of Oral Dexamethasone Without Immediate Antibiotics vs Placebo on Acute Sore Throat in Adults

Hayward

Moore

Jawad

et al. 2017

JAMA

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“…10 This clinical improvement translated to significantly shorter hospital admissions, a reduced likelihood of needing nebulised adrenaline and fewer return visits to healthcare professionals compared with children who did not receive corticosteroid treatment.…”

Section: Corticosteroidsmentioning

confidence: 99%

Assessment and management of viral croup in children

Wright¹,

Bush²

2016

Prescriber

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Croup is an acute respiratory illness that commonly affects preschool children. Although severe episodes requiring hospital admission occur in around 5 per cent of cases, the majority of children have a mild, self‐limiting illness, which can be safely managed at home. This article discusses the approach to clinical assessment and evidence‐based management of childhood croup in both hospital and primary care settings.

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mentioning

confidence: 99%

“…Most cases of the disease are associated with SARS caused by Para influenza or influenza viruses [3,4]. Fortunately, most registered children have mild symptoms, which resolve on their own within 48 h [3,4]. Moderate and severe courses are not frequently observed, but severe obstruction may lead to a respiratory failure and asphyxia [1][2][3][4].…”

mentioning

confidence: 99%

Pharmacotherapy of Acute Stenosing Laryngotracheitis. What Drugs Are Data-Based?

Ogorodova¹,

Петровский²

2012

Pediatr. farmakol.

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Acute stenosing laryngotracheitis is the most common cause of upper respiratory tract obstruction in children aged from 6 months to 6 years old and is a rapidly developing syndrome, which includes barking cough, hoarseness and stridor. The disease can be associated with development of respiratory failure and asphyxia, so its rational pharmacotherapy should be well known to pediatricians and emergency physicians. This review describes the drugs, effectiveness of which has been confirmed by credible evidence.

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Glucocorticoids for croup

Cited by 97 publications

References 89 publications

Effect of Oral Dexamethasone Without Immediate Antibiotics vs Placebo on Acute Sore Throat in Adults

Effect of Oral Dexamethasone Without Immediate Antibiotics vs Placebo on Acute Sore Throat in Adults

Assessment and management of viral croup in children

Pharmacotherapy of Acute Stenosing Laryngotracheitis. What Drugs Are Data-Based?

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