2015
DOI: 10.1371/journal.pone.0130085
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Glucocorticoids and Stress-Induced Changes in the Expression of PERIOD1 in the Rat Forebrain

Abstract: The secretion of glucocorticoids in mammals is under circadian control, but glucocorticoids themselves are also implicated in modulating circadian clock gene expression. We have shown that the expression of the circadian clock protein PER1 in the forebrain is modulated by stress, and that this effect is associated with changes in plasma corticosterone levels, suggesting a possible role for glucocorticoids in the mediation of stress-induced changes in the expression of PER1 in the brain. To study this, we asses… Show more

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Cited by 26 publications
(17 citation statements)
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“…In addition, a recent report demonstrates that stress modifies per gene expression in a tissue-specific manner in mammals (Al-Safadi et al 2015). Present results in a teleost evidence modifications in the hepatic oscillator by a stress-signaling hormone.…”
Section: Discussionsupporting
confidence: 58%
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“…In addition, a recent report demonstrates that stress modifies per gene expression in a tissue-specific manner in mammals (Al-Safadi et al 2015). Present results in a teleost evidence modifications in the hepatic oscillator by a stress-signaling hormone.…”
Section: Discussionsupporting
confidence: 58%
“…Stress is responsible of a transient misalignment of different oscillators in mammals, where the SCN lacks glucocorticoid receptors (Akashi and Nishida 2000;Segall and Amir 2010;Al-Safadi et al 2015) and therefore is unresponsive to the effect of these hormones (Balsalobre et al 2000;Al-Safadi et al 2015). In addition, a recent report demonstrates that stress modifies per gene expression in a tissue-specific manner in mammals (Al-Safadi et al 2015).…”
Section: Discussionmentioning
confidence: 99%
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“…This study also represents methodological advances in investigations of the interplay between glucocorticoids and extra-hypothalamic circadian clock gene expression. In previous studies, the endogenous rhythm in corticosterone was abolished by ADX and exogenous glucocorticoids were administered in the drinking water with daily rhythm dependent on nocturnal drinking behavior [22,24,27,58] or by use of time-specific intraperitoneal injections [21,26,28,30,59]. By lesioning the SCN, we abolished not only the daily rhythm in corticosterone, but all SCN-dependent physiological circadian rhythms that could potentially influence extra-hypothalamic circadian oscillators.…”
Section: Discussionmentioning
confidence: 66%
“…The endogenous secretion of glucocorticoids exhibits a prominent circadian rhythm [15][16][17][18], and the glucocorticoid receptor is highly expressed in the cerebellar cortex [19,20]. Furthermore, studies based on acute administration of hormone or adrenalectomy (ADX) suggest that glucocorticoids may entrain molecular circadian oscillators in both peripheral tissues [21][22][23] and in various parts of the forebrain, including the paraventricular nucleus [24,25], the amygdala [26,27], the bed nucleus of the stria terminalis [26,27], the hippocampus [28,29], and prefrontal cortex [30]; however, the possible role of glucocorticoids in the regulation of the cerebellar circadian oscillator has not been investigated.…”
Section: Introductionmentioning
confidence: 99%