Glucocorticoid receptors, fibromyalgia and low back pain

Lentjes, Eef G.W.M.; Griep, E.N.; Boersma, J.; Romijn, Fred P.H.T.M.; Kloer, E.R. de

doi:10.1016/s0306-4530(97)00061-9

Cited by 98 publications

(68 citation statements)

References 45 publications

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“…Therefore, neuroendocrinological factors are crucial in FM, which has been shown to be associated with sympathetic nervous system and HPA axis abnormalities (43). Hypocortisolemia in FM may be owing to a primary insufficiency of the adrenal gland or to centrally driven hypocortisolism (44). We think that the relationship of trauma and FM and the role of these abnormalities in this relationship should be investigated using hormones and biomarkers.…”

Section: Discussionmentioning

confidence: 99%

Post-Traumatic Stress Disorder, Alexithymia and Somatoform Dissociation in Patients with Fibromyalgia

Sönmezer¹,

Kavakçı²,

Peksen³

et al. 2014

Turk J Phys Med Rehab

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Section: Discussionmentioning

confidence: 99%

Post-Traumatic Stress Disorder, Alexithymia and Somatoform Dissociation in Patients with Fibromyalgia

Sönmezer¹,

Kavakçı²,

Peksen³

et al. 2014

Turk J Phys Med Rehab

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“…By the time, cortisol levels were not measured, as patients received cumulative depotdexamethasone, which may have compromised the hypothalamic-pituitary axis. Besides, plasma cortisol serum concentration was described as similar regarding healthy control and chronic low back pain 20,21 . Interestingly, the combination of both T ketamine and clonidine (Ket-CloG) did not result in a better analgesic profile compared to the correspondent drug alone and resulted in excessive sedation during the 6-h evaluation.…”

Section: Discussionmentioning

confidence: 84%

418 the Clinical and Laboratorial Evaluation of Transdermal Ketamine, Fentanyl, Clonidine or Their Combination in Chronic Low Back Pain

Lauretti

Mattos

Lima

et al. 2009

European Journal of Pain

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“…Unlike the depression for which the hypercortisolism is a common phenomenon, hypocortisolism is more common in chronic pain patients [79][80][81] . No escape from DST was observed in fibromyalgia (FMS) patients 81 .…”

Section: Pain and Hpa Axismentioning

confidence: 99%

Comorbidity of Depression and Pain: a review of shared contributing mechanisms

Li¹

2017

J Neurol Neuromedicine

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Pain and depression are two major health issues that we are currently facing. Chronic pain is the main reason that people seek medical care; and numerous people commit suicide each year because of depression. These two pathological conditions often coexist. Chronic pain patients are more likely to develop major depressive symptoms, while depressed patients reported more pain symptoms than normal healthy population. Understanding the common mechanisms associated with depression and pain is important for developing the effective strategy to treat this comorbidity. In this review, the potential mechanisms that contribute to both depression and pain are discussed from four perspectives, the morphological changes in the brain, monoamine deficiency, brain-derived neurotrophic factor (BDNF) reduction in the hippocampus, and the hypothalamicpituitary-adrenocortical (HPA) axis dysfunction.

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Glucocorticoid receptors, fibromyalgia and low back pain

Cited by 98 publications

References 45 publications

Post-Traumatic Stress Disorder, Alexithymia and Somatoform Dissociation in Patients with Fibromyalgia

Post-Traumatic Stress Disorder, Alexithymia and Somatoform Dissociation in Patients with Fibromyalgia

418 the Clinical and Laboratorial Evaluation of Transdermal Ketamine, Fentanyl, Clonidine or Their Combination in Chronic Low Back Pain

Comorbidity of Depression and Pain: a review of shared contributing mechanisms

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