Glucocorticoid receptor sensitivity in early pregnancy in an African American cohort

Clarke, L; Corwin, Elizabeth J.; Dunlop, Anne L.; Hankus, Allison; Bradner, Joshua M.; Paul, Sudeshna; Jiao, Yunshen; Smith, Alicia K.; Patrushev, Nikolay; Mullé, Jennifer G.; Read, Timothy D.; Hogue, Carol J.; Pearce, Bradley D.

doi:10.1111/aji.13252

Cited by 2 publications

(1 citation statement)

References 62 publications

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“…A major assay to analyze the function of immune cells in the setting of chronic stress is the detection of glucocorticoid resistance (GCR). For this assay, lipopolysaccharide (LPS) or another stimulator is used to induce a pro-inflammatory state in immune cells; glucocorticoid is then added at increasing concentrations [ 204 ]. The mean concentration of glucocorticoid needed to blunt LPS-induced cytokine production by 50% (e.g., dexamethasone IC50) is used as the primary measure of GCR.…”

Section: Biomarkers Of Stress and The Biology Of Adversitymentioning

confidence: 99%

By what molecular mechanisms do social determinants impact cardiometabolic risk?

et al. 2023

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While it is well known from numerous epidemiologic investigations that social determinants (socioeconomic, environmental, and psychosocial factors exposed to over the life-course) can dramatically impact cardiovascular health, the molecular mechanisms by which social determinants lead to poor cardiometabolic outcomes are not well understood. This review comprehensively summarizes a variety of current topics surrounding the biological effects of adverse social determinants (i.e., the biology of adversity), linking translational and laboratory studies with epidemiologic findings. With a strong focus on the biological effects of chronic stress, we highlight an array of studies on molecular and immunological signaling in the context of social determinants of health (SDoH). The main topics covered include biomarkers of sympathetic nervous system and hypothalamic–pituitary–adrenal axis activation, and the role of inflammation in the biology of adversity focusing on glucocorticoid resistance and key inflammatory cytokines linked to psychosocial and environmental stressors (PSES). We then further discuss the effect of SDoH on immune cell distribution and characterization by subset, receptor expression, and function. Lastly, we describe epigenetic regulation of the chronic stress response and effects of SDoH on telomere length and aging. Ultimately, we highlight critical knowledge gaps for future research as we strive to develop more targeted interventions that account for SDoH to improve cardiometabolic health for at-risk, vulnerable populations.

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Section: Biomarkers Of Stress and The Biology Of Adversitymentioning

confidence: 99%

By what molecular mechanisms do social determinants impact cardiometabolic risk?

et al. 2023

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Intergenerational Impacts of Maternal Stress on Early Childhood Atopy in Black Americans

Engel

Pike

Cohen

et al. 2021

Journal of Pediatric Psychology

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Objective Black children are disproportionately affected by atopic diseases (i.e., atopic dermatitis, allergic rhinitis, asthma, and food allergies), with health disparities present in early life. Studies in White samples suggest that maternal stress confers risk for offspring atopy, yet little is known about these relationships in Black populations. This study seeks to (a) examine the relationship between self-reported and physiological indicators of maternal stress and offspring atopy and (b) explore warm and responsive caregiving as a potential protective factor in Black Americans. Methods A sample of 179 Black mother–child dyads of varying socioeconomic status participated in a prospective longitudinal study. Mothers completed self-reports of childhood trauma, prenatal stress, postnatal stress, and physician diagnosis of offspring atopy; provided blood samples to assess physiological responses to chronic stress exposure; and participated in a behavioral task with their infant. Results Maternal self-reports of childhood trauma, prenatal stress, and postnatal stress were not associated with offspring diagnosis of atopy by 2–3 years of age. Mothers who produced a smaller inflammatory response during pregnancy were more likely to have an offspring with atopy by 2–3 years of age. Warm and responsive parenting demonstrated a protective effect; the positive association between maternal stress and offspring atopy was less apparent in cases of mother–child interactions characterized by high levels warm and responsive parenting. Conclusion Failure to replicate previous findings suggests that the maternal stress–offspring atopy relationship is complex. Future studies must examine the unique stressors in Black Americans, as well as caregiving as a potential protective factor.

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Glucocorticoid receptor sensitivity in early pregnancy in an African American cohort

Cited by 2 publications

References 62 publications

By what molecular mechanisms do social determinants impact cardiometabolic risk?

By what molecular mechanisms do social determinants impact cardiometabolic risk?

Intergenerational Impacts of Maternal Stress on Early Childhood Atopy in Black Americans

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