Glucocorticoid Receptor and Myocyte Enhancer Factor 2 Cooperate to Regulate the Expression of c-JUN in a Neuronal Context

Speksnijder, Niels; Christensen, Kenneth Vielsted; Didriksen, Michael; Kloet, E. Ronald de; Datson, Nicole A.

doi:10.1007/s12031-012-9809-2

Cited by 14 publications

(13 citation statements)

References 41 publications

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“…Myocyte enhancer factor 2D (MEF2D) can target methyltransferase complexes to specific genes to mark them for gene expression [52]. MEF2 has recently been shown to be regulated via the glucocorticoid receptor [53], which may be one of the mechanisms by which stress hormones affect the epigenome. Finally, PR domain containing 16 (PRDM16) is involved in positioning and removing specific chromatin modifications at enhancer regions of Notch target genes during olfactory neuron differentiation in drosophila [54].…”

Section: Introductionmentioning

confidence: 99%

Epigenetic mechanisms in migraine: a promising avenue?

Eising

Datson

Maagdenberg

et al. 2013

BMC Med

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Migraine is a disabling common brain disorder typically characterized by attacks of severe headache and associated with autonomic and neurological symptoms. Its etiology is far from resolved. This review will focus on evidence that epigenetic mechanisms play an important role in disease etiology. Epigenetics comprise both DNA methylation and post-translational modifications of the tails of histone proteins, affecting chromatin structure and gene expression. Besides playing a role in establishing cellular and developmental stage-specific regulation of gene expression, epigenetic processes are also important for programming lasting cellular responses to environmental signals. Epigenetic mechanisms may explain how non-genetic endogenous and exogenous factors such as female sex hormones, stress hormones and inflammation trigger may modulate attack frequency. Developing drugs that specifically target epigenetic mechanisms may open up exciting new avenues for the prophylactic treatment of migraine.

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Section: Introductionmentioning

confidence: 99%

Epigenetic mechanisms in migraine: a promising avenue?

Eising

Datson

Maagdenberg

et al. 2013

BMC Med

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“…Notch and retinoid acid signaling play important roles in neural development [54], [55]. The MERLIN identified regulators also include the transcription factors, MLLT3 myeloid differentiation [56] and BCOR associated with tissue homeostasis, [57] that exhibit protein interactions with nuclear receptors (NR3C1 [58], and NRIP1) which interact with retinoids to regulate cell differentiation [59].…”

Section: Resultsmentioning

confidence: 99%

Integrated Module and Gene-Specific Regulatory Inference Implicates Upstream Signaling Networks

Roy

Lagree

Hou³

et al. 2013

PLoS Comput Biol

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Regulatory networks that control gene expression are important in diverse biological contexts including stress response and development. Each gene's regulatory program is determined by module-level regulation (e.g. co-regulation via the same signaling system), as well as gene-specific determinants that can fine-tune expression. We present a novel approach, Modular regulatory network learning with per gene information (MERLIN), that infers regulatory programs for individual genes while probabilistically constraining these programs to reveal module-level organization of regulatory networks. Using edge-, regulator- and module-based comparisons of simulated networks of known ground truth, we find MERLIN reconstructs regulatory programs of individual genes as well or better than existing approaches of network reconstruction, while additionally identifying modular organization of the regulatory networks. We use MERLIN to dissect global transcriptional behavior in two biological contexts: yeast stress response and human embryonic stem cell differentiation. Regulatory modules inferred by MERLIN capture co-regulatory relationships between signaling proteins and downstream transcription factors thereby revealing the upstream signaling systems controlling transcriptional responses. The inferred networks are enriched for regulators with genetic or physical interactions, supporting the inference, and identify modules of functionally related genes bound by the same transcriptional regulators. Our method combines the strengths of per-gene and per-module methods to reveal new insights into transcriptional regulation in stress and development.

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“…Notably, the expression of the c-jun gene in cultured fibroblasts and pheochromocytoma cells was suppressed within 30 min of exposure to dexamethasone [28,29], which is apparently indicative of the activation of cell-specific pathways underlying gene expression regulation by the hormone. Notably, the regulation of the synthesis of proteins of Fos and Jun families has some features specific to individual proteins.…”

Section: Discussionmentioning

confidence: 98%

Effect of dexamethasone on the expression of immediate early genes c-fos and c-jun in different regions of the neonatal brain

2016

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The ratio of the expression levels of the immediate early genes c-jun and c-fos that encode components of the AP-1 transcription complex determines the direction of changes in the expression of genes controlled by the complex, including changes induced by glucocorticoids. The aim of the present work was to assess the levels of mRNA encoded by genes c-jun and c-fos and the ratio of expression levels of these genes in various regions of the neonatal rat brain after the administration of dexamethasone, a selective ligand of the glucocorticoid receptor. The level of mRNA encoded by the immediate early gene c-fos in the hippocampus and prefrontal cortex of 3-day-old rat pups was elevated at 30, 60, and 120 min after dexamethasone administration. The basal level of c-fos gene expression in the brainstem was higher than in the cortex and hippocampus, and administration of the hormone was followed by a reduction in the amount of transcript detectable in the brainstem after 2 h. As a result, the ratio of c-jun to c-fos transcript levels in the brainstem of neonatal rats was doubled after dexamethasone administration. The dexamethasone-induced shift of the ratio of c-jun to c-fos transcript levels in the brainstem of neonatal rats towards a predominance of c-jun reported for the first time in the present work may induce the expression of genes that contain AP-1 response elements in the promoters, since the glucocorticoid receptor can be involved in protein-protein interactions with the Jun/Jun homodimer of the AP-1 complex.

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Glucocorticoid Receptor and Myocyte Enhancer Factor 2 Cooperate to Regulate the Expression of c-JUN in a Neuronal Context

Cited by 14 publications

References 41 publications

Epigenetic mechanisms in migraine: a promising avenue?

Epigenetic mechanisms in migraine: a promising avenue?

Integrated Module and Gene-Specific Regulatory Inference Implicates Upstream Signaling Networks

Effect of dexamethasone on the expression of immediate early genes c-fos and c-jun in different regions of the neonatal brain

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