Glucocorticoid‐mediated inhibition of RANTES expression in human T lymphocytes

Wingett, Denise; Forcier, Kristin; Nielson, Christopher

doi:10.1016/s0014-5793(96)01238-0

Cited by 20 publications

(11 citation statements)

References 22 publications

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“…In the group with all UC patients without 5ASA, consisting of six patients in relapse and one in remission, the significant difference could be explained by a very low value for the patient in remission. It is known that glucocorticoids mediate inhibition of RANTES expression in T-lymphocytes [37] and epithelial cells of the lung [38] and our results could indicate a similar action of 5ASA. To our knowledge this has never previously been reported.…”

Section: Discussionsupporting

confidence: 77%

Expression of platelet P-selectin and detection of soluble P-selectin, NPY and RANTES in patients with inflammatory bowel disease

Fägerstam¹,

Whiss²,

Ström

et al. 2000

Inflamm res.

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Patients with IBD in remission have higher basal platelet surface P-selectin expression. An exaggerated platelet activity with increased expression of platelet P-selectin and release of inflammatory mediators such as RANTES, which is chemotactic and induce chemokine production, could have a reinforcing and aggravating influence on the inflammatory response and increase the susceptibility to IBD. In addition IL-8 has a down-regulating effect on platelet surface P-selectin expression and 5ASA medication seems to lower plasma RANTES. If 5ASA is responsible for lowering the concentration of RANTES this could be one of the beneficial outcomes of 5ASA medication.

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Section: Discussionsupporting

confidence: 77%

Expression of platelet P-selectin and detection of soluble P-selectin, NPY and RANTES in patients with inflammatory bowel disease

Fägerstam¹,

Whiss²,

Ström

et al. 2000

Inflamm res.

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“…According to previous studies, steroid hormones may intensify or weaken ADHD symptoms (Martel et al 2009; Gaysina et al 2012; Torregrossa et al 2012; Liu and Wang 2015; Roberts 2016). Moreover, they may also modulate cortical and/or striatal dopamine concentrations directly and/or indirectly by modulating the secretion of cytokines and chemokines (Xiao and Becker 1994; Batuman et al 1995; Elenkov et al 1996; Ramírez et al 1996; Franchimont et al 1999; Galon et al 2002; Fukakusa et al 2005; Wingett et al 2011; Martino et al 2012; Chen et al 2017a). Interestingly, the present study revealed inverse correlation between inflammatory markers and steroid hormone contents in SHRs.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, as is widely accepted, glucocorticoids might down-regulate a great number of cytokines, such as interleukin (IL)-1β, IL-6, IL-8, IL-12, IL-18 and tumour necrosis factor alpha (TNF-α) as well as chemokines, such as regulated on activation, normal T-cell expressed and secreted (RANTES) and monocyte chemoattractant protein-1 (MCP-1). However, anti-inflammatory cytokines such as IL-10 and transforming growth factor beta (TGF-β), as well as chemokine IP-10, are up-regulated by these hormones (Batuman et al 1995; Elenkov et al 1996; Ramírez et al 1996; Franchimont et al 1999; Galon et al 2002; Fukakusa et al 2005; Wingett et al 2011; Martino et al 2012). Interestingly, significantly higher serum levels of IL-6 and IL-10 were recently reported in children with ADHD (Donfrancesco et al 2016).…”

Section: Introductionmentioning

confidence: 99%

ADHD pathogenesis in the immune, endocrine and nervous systems of juvenile and maturating SHR and WKY rats

et al. 2019

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RationaleAttention-deficit/hyperactivity disorder (ADHD) is one of the most common neurobehavioural disorders with morphological and functional brain abnormalities. However, there is a growing body of evidence that abnormalities in the immune and endocrine systems may also account for the ADHD pathogenesis.ObjectivesTo test ADHD pathogenesis in neurological, immune and endocrine systems, this study examined the concentrations of cytokines, chemokines, oxidative stress markers, metabolic parameters, steroid hormones and steroidogenic enzymes in the serum and/or tissues of spontaneously hypertensive rats (SHRs, animal model of ADHD) and Wistar Kyoto rats (WKYs, control animals). Moreover, the volume of the medial prefrontal cortex (mPFC) as well as the density of dopamine 2 (D2) receptor-expressing cells and tyrosine hydroxylase (TH)-positive nerve fibres in it was also elucidated.MethodsPeripheral blood, spleen and adrenal gland samples, as well as brain sections collected on day 35 (juvenile) and day 70 (maturating) from SHRs and WKYs, were processed by ELISA and immunohistochemistry, respectively.ResultsThe results show significant increases of serum and/or tissue concentrations of cytokines, chemokines and oxidative stress markers in juvenile SHRs when compared to the age-matched WKYs. These increases were accompanied by a lowered volume of the mPFC and up-regulation of D2 in this brain region. In maturating SHRs, the levels of inflammatory and oxidative stress markers were normalised and accompanied by elevated contents of steroid hormones.ConclusionsSignificant elevations of serum and/or tissue contents of cytokines, chemokines and oxidative stress markers as well as volumetric and neurochemical alterations in the mPFC of juvenile SHRs may suggest the cooperation of neurological and immune systems in the ADHD pathogenesis. Elevated levels of steroid hormones in maturating SHRs may be a compensatory effect involved in reducing inflammation and ADHD symptoms.

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“…The present finding that shows steroids can significantly decrease the release of RANTES from cultured PBMCs underlines the importance of steroid treatment of allergic diseases, and confirms previous studies. In particular, it has been shown that dexamethasone dramatically inhibits RANTES mRNA expression in human PBMCs and in T cells (18), corticosteroids downregulate synthesis and/ or release of RANTES from bronchial epithelial cells (19,20) and topical fluticasone inhibits allergen induced increase in the production/release of chemokines (21).…”

Section: Discussionmentioning

confidence: 99%

Steroid and Antihistamines Modulate Rantes Release in Cultured Peripheral Blood Mononuclear Cells of Atopic Patients

Gioacchino

Verna

Cavallucci

et al. 2002

Int J Immunopathol Pharmacol

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RANTES plays a crucial role in cell recruitment in allergic inflammation. We investigated the pharmacological modulation of RANTES release in cultured peripheral blood mononuclear cells obtained from allergic patients with active asthma. Chemokine production was assessed before and after 15 day treatment with histamine-I receptor antagonists (Loratadine or Cetirizine) and a steroid (Deflazacort), both in unstimulated and PHA-stimulated cell cultures. Results were compared with those obtained from placebo-treated patients. During the treatment period, patients recorded morning and evening peak expiratory flow (PEF) by mini-Wright.PEF absolute values and diurnal variability significantly improved respect to the pre-treatment in steroid-treated patients, in comparison to the placebo and antihistamine-treated groups (p

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Glucocorticoid‐mediated inhibition of RANTES expression in human T lymphocytes

Cited by 20 publications

References 22 publications

Expression of platelet P-selectin and detection of soluble P-selectin, NPY and RANTES in patients with inflammatory bowel disease

Expression of platelet P-selectin and detection of soluble P-selectin, NPY and RANTES in patients with inflammatory bowel disease

ADHD pathogenesis in the immune, endocrine and nervous systems of juvenile and maturating SHR and WKY rats

Steroid and Antihistamines Modulate Rantes Release in Cultured Peripheral Blood Mononuclear Cells of Atopic Patients

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