Glucocorticoid-Induced Transcription Factor 1 (GLCCI1) Variant Impacts the Short-Term Response to Intranasal Corticosteroids in Chinese Han Patients with Seasonal Allergic Rhinitis

Dai, Yinmei; Ni, Siyang; Wu, Feng; Zhao, Xiuli

doi:10.12659/msm.908814

Cited by 2 publications

(4 citation statements)

References 22 publications

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“…A study focused on the GLCCI1 genotype, rs37973 has demonstrated that AR may be insensitive to glucocorticoids due to its inherited nature [ 25 ]. This genotype has been associated with asthma patients being less sensitive to inhaled corticosteroids (ICS) [ 26 ] and AR patients being less susceptible to INCS [ 22 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…When the TNSS rate of change is 0.55 or higher, INCS therapy is efective; if it is below 0.55, it indicates INSC insensitivity [17,21,22].…”

Section: Discussionmentioning

confidence: 99%

“…The rate of change in TNSS is determined by dividing the absolute difference between TNSS before and after treatment by the TNSS before treatment. When the TNSS rate of change is 0.55 or higher, INCS therapy is effective; if it is below 0.55, it indicates INSC insensitivity [ 17 , 21 , 22 ].…”

Section: Methodsmentioning

confidence: 99%

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Development and Evaluation of a Nomogram for INCS Insensitivity in Chinese Adults with Allergic Rhinitis

Sun

Liu

Yan

2023

International Journal of Clinical Practice

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Objective. The objective of this study was to design and validate a nomogram of intranasal corticosteroid (INCS) insensitivity for adult patients with allergic rhinitis (AR). Methods. Training and validation datasets comprised randomly divided groups of AR patients diagnosed between 2019 and 2022, with a 7 : 3 ratio. These patients were categorized according to their INCS insensitivity status, and LASSO and multivariate logistic regression analyses were conducted to identify associated risk factors. These factors were incorporated into a nomogram for predicting INCS insensitivity. The performance of the nomogram was assessed using receiver operating characteristic (ROC) curves, calibration curves, and discrimination techniques. Results. In this study, 313 patients were included, of which 120 (38.3%) showed INCS insensitivity. The type of AR, comorbidities, family history of AR, and duration of AR were identified as predictors and incorporated into the nomogram using least absolute shrinkage and selection operator and multivariate logistic regression. The calibration curves showed excellent agreement between predicted and actual probabilities of INCS insensitivity in both the training and validation sets. The area under the curve values observed in the validation set were 0.918 (95% confidence interval, 0.859–0.943), and 0.932 (95% confidence interval, 0.849–0.953) in the training set, indicating strong performance on both sets. Decision curve analysis showed that the constructed nomogram yielded a net clinical benefit for AR patients. Conclusion. The nomogram constructed from risk predictors of INCS insensitivity in patients with AR demonstrated strong predictive power and enabled clinicians to identify high-risk patients, aiding them in developing an optimal treatment plan for AR.

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Section: Discussionmentioning

confidence: 99%

“…When the TNSS rate of change is 0.55 or higher, INCS therapy is efective; if it is below 0.55, it indicates INSC insensitivity [17,21,22].…”

Section: Discussionmentioning

confidence: 99%

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Development and Evaluation of a Nomogram for INCS Insensitivity in Chinese Adults with Allergic Rhinitis

Sun

Liu

Yan

2023

International Journal of Clinical Practice

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“…Also, the GLCCI1 was reported to be associated with the development of asthma. [15][16][17][18] However, there is less evidence of its association with the development of AR. Thus, our study aimed to identify whether the polymorphisms in the GLCCI1 rs37937 are associated with the development of AR in a Chinese Han population, and to assess the correlation between the gene polymorphisms and the response to INCS as well.…”

Section: Introductionmentioning

confidence: 99%

Glucocorticoid-Induced Transcript 1(GLCCI1) SNP rs37937 Is Associated With the Risk of Developing Allergic Rhinitis and the Response to Intranasal Corticosteroids in a Chinese Han Population

Peng

Zhan

et al. 2023

Am J Rhinol�Allergy

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Background Evidence has shown that glucocorticoid-induced transcript 1 (GLCCI1) single nucleotide polymorphism (SNP) rs37937 is associated with asthma. Objectives The objective of this study was to investigate whether the GLCCI1 SNP rs37937 is a risk factor for allergic rhinitis (AR) in a Chinese Han population. Methods A total of 220 individuals including 109 AR patients and 111 healthy subjects were included. The genotyping of GLCCI1 rs37973 was performed by the SNaPshot method. The correlations of rs37973 polymorphism, AR risk, and clinical characteristics were further analyzed, as well as the treatment response to intranasal corticosteroids (INCS) in AR patients of different genotypes. Results Three GLCCI1 rs37973 SNP genotypes were identified in both AR patients and healthy subjects. Significant association between rs37973 polymorphism and AR under allele model, dominant model, heterozygote model, and homozygote model were shown. The A allele frequency of SNP rs37973 in AR was significantly higher than that in controls. The serum total immunoglobulin E (IgE) in AR patients of AA genotype was significantly higher than in patients of GA and GG genotype, and the serum total IgE in GA genotype was significantly higher than in GG genotype. Interestingly, after 4 weeks of INCS treatment for AR patients, the improvement of the nasal itching score, sneezing score, runny nose score, total nasal symptom score, and visual analog scale score of the GG genotype were worse than the AA or GA genotype. Conclusion The GLCCI1 rs37937 polymorphism is associated with the risk of developing AR and the response to INCS treatment in the Chinese Han population.

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Glucocorticoid-Induced Transcription Factor 1 (GLCCI1) Variant Impacts the Short-Term Response to Intranasal Corticosteroids in Chinese Han Patients with Seasonal Allergic Rhinitis

Cited by 2 publications

References 22 publications

Development and Evaluation of a Nomogram for INCS Insensitivity in Chinese Adults with Allergic Rhinitis

Development and Evaluation of a Nomogram for INCS Insensitivity in Chinese Adults with Allergic Rhinitis

Glucocorticoid-Induced Transcript 1(GLCCI1) SNP rs37937 Is Associated With the Risk of Developing Allergic Rhinitis and the Response to Intranasal Corticosteroids in a Chinese Han Population

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